Guidelines for the standardization of pre-analytical variables for salivary biomarker studies in Alzheimer's disease research: An updated review and consensus of the Salivary Biomarkers for Dementia Research Working Group.
There is a pressing need for accessible biomarkers with high diagnostic accuracy for Alzheimer's disease (AD) diagnosis to facilitate widespread screening, particularly in underserved groups. Saliva is an emerging specimen for measuring AD biomarkers, with distinct contexts of use that could complem...
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| Format: | Article |
| Publication date: | 2024 |
| Country: | España |
| Institution: | Instituto de Salud Carlos III (ISCIII) |
| Repository: | Repisalud |
| Language: | English |
| OAI Identifier: | oai:repisalud.isciii.es:20.500.12105/26338 |
| Online Access: | https://hdl.handle.net/20.500.12105/26338 |
| Access Level: | Open access |
| Keyword: | Alzheimer's disease Biomarkers Measurement protocol Non‐invasive Pre‐analytical variables Saliva Sampling |
| _version_ | 1878739704690507776 |
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| author | Ng, Ted K S |
| author2 | Udeh-Momoh, Chinedu Lim, Mei-Ann Gleerup, Helena Sophia Leifert, Wayne Ajalo, Catherine Ashton, Nicholas Zetterberg, Henrik Rissman, Robert A Winston, Charisse N O' Bryant, Sid Jenkins, Robert Carro, Eva Orive, Gorka Tamburin, Stefano Olvera-Rojas, Marcos Solis-Urra, Patricio Esteban-Cornejo, Irene Santos, Gustavo Alves Andrade Dos Rajan, Kumar B Koh, David Simonsen, Anja Hviid Slowey, Paul D Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment: Biofluid Based Biomarkers Professional Interest Area Salivary Biomarkers for Dementia Research Working Group (ISTAART‐BBB‐PIA‐SWG) |
| author2_role | author author author author author author author author author author author author author author author author author author author author author author author |
| author_browse | Ajalo, Catherine Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment: Biofluid Based Biomarkers Professional Interest Area Salivary Biomarkers for Dementia Research Working Group (ISTAART‐BBB‐PIA‐SWG) Ashton, Nicholas Carro, Eva Esteban-Cornejo, Irene Gleerup, Helena Sophia Jenkins, Robert Koh, David Leifert, Wayne Lim, Mei-Ann Ng, Ted K S O' Bryant, Sid Olvera-Rojas, Marcos Orive, Gorka Rajan, Kumar B Rissman, Robert A Santos, Gustavo Alves Andrade Dos Simonsen, Anja Hviid Slowey, Paul D Solis-Urra, Patricio Tamburin, Stefano Udeh-Momoh, Chinedu Winston, Charisse N Zetterberg, Henrik |
| author_facet | Ng, Ted K S Udeh-Momoh, Chinedu Lim, Mei-Ann Gleerup, Helena Sophia Leifert, Wayne Ajalo, Catherine Ashton, Nicholas Zetterberg, Henrik Rissman, Robert A Winston, Charisse N O' Bryant, Sid Jenkins, Robert Carro, Eva Orive, Gorka Tamburin, Stefano Olvera-Rojas, Marcos Solis-Urra, Patricio Esteban-Cornejo, Irene Santos, Gustavo Alves Andrade Dos Rajan, Kumar B Koh, David Simonsen, Anja Hviid Slowey, Paul D Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment: Biofluid Based Biomarkers Professional Interest Area Salivary Biomarkers for Dementia Research Working Group (ISTAART‐BBB‐PIA‐SWG) |
| author_role | author |
| collection | Repisalud |
| description | There is a pressing need for accessible biomarkers with high diagnostic accuracy for Alzheimer's disease (AD) diagnosis to facilitate widespread screening, particularly in underserved groups. Saliva is an emerging specimen for measuring AD biomarkers, with distinct contexts of use that could complement blood and cerebrospinal fluid and detect various analytes. An interdisciplinary, international group of AD and related dementias (ADRD) researchers convened and performed a narrative review of published studies on salivary AD biomarkers. We critically appraised the current state of the literature, examining both consistencies and discrepancies in existing pre-analytical variables and methodologies. We discussed how various pre-analytical variables could influence the detection and quantification of salivary biomarkers, showed technologies available to standardize collection procedures, and proposed a standardized pre-analytical protocol to guide future studies on salivary AD biomarker examinations. We identified potential contexts of use, gaps, and priorities and proposed future research directions. HIGHLIGHTS: Given its non-invasive nature, wider accessibility, and cultural acceptability, particularly in low-resourced settings, saliva is a biofluid complementary to blood and CSF. Current salivary AD biomarker studies do not control for many confounding pre-analytical variables during the sampling process, potentially leading to inaccurate salivary biomarker readings and conclusions, contributing to conflicting findings. Reviewing the current literature, including the consistencies and non-consistencies observed in the existing parameters and methodologies, discussing how they can affect salivary AD biomarker detection and quantification. Proposing a standardized salivary pre-analytical protocol, identifying the gaps and prioritizations needed to move this area forward, proposing future directions and potential contexts of use. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_c67e297d3f9de0c052d8b92c73812ad8 |
| institution | Instituto de Salud Carlos III (ISCIII) |
| instname_str | Instituto de Salud Carlos III (ISCIII) |
| language | eng |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:repisalud.isciii.es:20.500.12105/26338 |
| publishDate | 2024 |
| publishDateSort | 2024 |
| publisher | Wiley |
| publisherStr | Wiley |
| reponame_str | Repisalud |
| spelling | Guidelines for the standardization of pre-analytical variables for salivary biomarker studies in Alzheimer's disease research: An updated review and consensus of the Salivary Biomarkers for Dementia Research Working Group. Ng, Ted K S Udeh-Momoh, Chinedu Lim, Mei-Ann Gleerup, Helena Sophia Leifert, Wayne Ajalo, Catherine Ashton, Nicholas Zetterberg, Henrik Rissman, Robert A Winston, Charisse N O' Bryant, Sid Jenkins, Robert Carro, Eva Orive, Gorka Tamburin, Stefano Olvera-Rojas, Marcos Solis-Urra, Patricio Esteban-Cornejo, Irene Santos, Gustavo Alves Andrade Dos Rajan, Kumar B Koh, David Simonsen, Anja Hviid Slowey, Paul D Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment: Biofluid Based Biomarkers Professional Interest Area Salivary Biomarkers for Dementia Research Working Group (ISTAART‐BBB‐PIA‐SWG) Alzheimer's disease Biomarkers Measurement protocol Non‐invasive Pre‐analytical variables Saliva Sampling There is a pressing need for accessible biomarkers with high diagnostic accuracy for Alzheimer's disease (AD) diagnosis to facilitate widespread screening, particularly in underserved groups. Saliva is an emerging specimen for measuring AD biomarkers, with distinct contexts of use that could complement blood and cerebrospinal fluid and detect various analytes. An interdisciplinary, international group of AD and related dementias (ADRD) researchers convened and performed a narrative review of published studies on salivary AD biomarkers. We critically appraised the current state of the literature, examining both consistencies and discrepancies in existing pre-analytical variables and methodologies. We discussed how various pre-analytical variables could influence the detection and quantification of salivary biomarkers, showed technologies available to standardize collection procedures, and proposed a standardized pre-analytical protocol to guide future studies on salivary AD biomarker examinations. We identified potential contexts of use, gaps, and priorities and proposed future research directions. HIGHLIGHTS: Given its non-invasive nature, wider accessibility, and cultural acceptability, particularly in low-resourced settings, saliva is a biofluid complementary to blood and CSF. Current salivary AD biomarker studies do not control for many confounding pre-analytical variables during the sampling process, potentially leading to inaccurate salivary biomarker readings and conclusions, contributing to conflicting findings. Reviewing the current literature, including the consistencies and non-consistencies observed in the existing parameters and methodologies, discussing how they can affect salivary AD biomarker detection and quantification. Proposing a standardized salivary pre-analytical protocol, identifying the gaps and prioritizations needed to move this area forward, proposing future directions and potential contexts of use. Wiley https://hdl.handle.net/20.500.12105/26338 |
| spellingShingle | Guidelines for the standardization of pre-analytical variables for salivary biomarker studies in Alzheimer's disease research: An updated review and consensus of the Salivary Biomarkers for Dementia Research Working Group. Ng, Ted K S Alzheimer's disease Biomarkers Measurement protocol Non‐invasive Pre‐analytical variables Saliva Sampling |
| title | Guidelines for the standardization of pre-analytical variables for salivary biomarker studies in Alzheimer's disease research: An updated review and consensus of the Salivary Biomarkers for Dementia Research Working Group. |
| title_full | Guidelines for the standardization of pre-analytical variables for salivary biomarker studies in Alzheimer's disease research: An updated review and consensus of the Salivary Biomarkers for Dementia Research Working Group. |
| title_fullStr | Guidelines for the standardization of pre-analytical variables for salivary biomarker studies in Alzheimer's disease research: An updated review and consensus of the Salivary Biomarkers for Dementia Research Working Group. |
| title_full_unstemmed | Guidelines for the standardization of pre-analytical variables for salivary biomarker studies in Alzheimer's disease research: An updated review and consensus of the Salivary Biomarkers for Dementia Research Working Group. |
| title_short | Guidelines for the standardization of pre-analytical variables for salivary biomarker studies in Alzheimer's disease research: An updated review and consensus of the Salivary Biomarkers for Dementia Research Working Group. |
| title_sort | Guidelines for the standardization of pre-analytical variables for salivary biomarker studies in Alzheimer's disease research: An updated review and consensus of the Salivary Biomarkers for Dementia Research Working Group. |
| topic | Alzheimer's disease Biomarkers Measurement protocol Non‐invasive Pre‐analytical variables Saliva Sampling |
| topic_facet | Alzheimer's disease Biomarkers Measurement protocol Non‐invasive Pre‐analytical variables Saliva Sampling |
| url | https://hdl.handle.net/20.500.12105/26338 |