Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease
Background: Alzheimer's disease is a common debilitating dementia with known heritability, for which 20 late onset susceptibility loci have been identified, but more remain to be discovered. This study sought to identify new susceptibility genes, using an alternative gene-wide analytical approach wh...
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| Format: | Article |
| Status: | Published version |
| Publication date: | 2014 |
| Country: | España |
| Institution: | Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau) |
| Repository: | r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau |
| OAI Identifier: | oai:iibsantpau.fundanetsuite.com:p8909 |
| Online Access: | https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=8909 |
| Access Level: | Open access |
| _version_ | 1878739604812595200 |
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| author | Escott-Price, V |
| author2 | Bellenguez, C Wang, LS Choi, SH Harold, D Jones, L Holmans, P Gerrish, A Vedernikov, A Richards, A DeStefano, AL Lambert, JC Ibrahim-Verbaas, CA Naj, AC Sims, R Jun, G Bis, JC Beecham, GW Grenier-Boley, B Russo, G Thornton-Wells, TA Denning, N Smith, AV Chouraki, V Thomas, C Ikram, MA Zelenika, D Vardarajan, BN Kamatani, Y Lin, CF Schmidt, H Kunkle, B Dunstan, ML Vronskaya, M Johnson, AD Ruiz, A Bihoreau, MT Reitz, C Pasquier, F Hollingworth, P Hanon, O Fitzpatrick, AL Buxbaum, JD Campion, D Crane, PK Baldwin, C Becker, T Gudnason, V Cruchaga, C Craig, D Amin, N Berr, C Lopez, OL De Jager, PL Deramecourt, V Johnston, JA Evans, D Lovestone, S Letenneur, L Hernandez, I Rubinsztein, DC Eiriksdottir, G Sleegers, K Goate, AM Fievet, N Huentelman, MJ Gill, M Brown, K Kamboh, MI Keller, L Barberger-Gateau, P McGuinness, B Larson, EB Myers, AJ Dufouil, C Todd, S Wallon, D Love, S Rogaeva, E Gallacher, J St George-Hyslop, P Clarimon, J Lleo, A Bayer, A Tsuang, DW Yu, L Tsolaki, M Bossu, P Spalletta, G Proitsi, P Collinge, J Sorbi, S Garcia, FS Fox, NC Hardy, J Naranjo, MCD Bosco, P Clarke, R Brayne, C Galimberti, D Scarpini, E Bonuccelli, U Mancuso, M Siciliano, G Moebus, S Mecocci, P Del Zompo, M Maier, W Hampel, H Pilotto, A Frank-Garcia, A Panza, F Solfrizzi, V Caffarra, P Nacmias, B Perry, W Mayhaus, M Lannfelt, L Hakonarson, H Pichler, S Carrasquillo, MM Ingelsson, M Beekly, D Alvarez, V Zou, FG Valladares, O Younkin, SG Coto, E Hamilton-Nelson, KL Gu, W Razquin, C Pastor, P Mateo, I Owen, MJ Faber, KM Jonsson, PV Combarros, O O'Donovan, MC Cantwell, LB Soininen, H Blacker, D Mead, S Mosley, TH Bennett, DA Harris, TB Fratiglioni, L Holmes, C de Bruijn, RFAG Passmore, P Montine, TJ Bettens, K Rotter, JI Brice, A Morgan, K Foroud, TM Kukull, WA Hannequin, D Powell, JF Nalls, MA Ritchie, K Lunetta, KL Kauwe, JSK Boerwinkle, E Riemenschneider, M Boada, M Hiltunen, M Martin, ER Schmidt, R Rujescu, D Dartigues, JF Mayeux, R Tzourio, C Hofman, A Nothen, MM Graff, C Psaty, BM Haines, JL Lathrop, M Pericak-Vance, MA Launer, LJ Van Broeckhoven, C Farrer, LA van Duijn, CM Ramirez, A Seshadri, S Schellenberg, GD Amouyel, P Williams, J |
| author2_role | author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| author_browse | Alvarez, V Amin, N Amouyel, P Baldwin, C Barberger-Gateau, P Bayer, A Becker, T Beecham, GW Beekly, D Bellenguez, C Bennett, DA Berr, C Bettens, K Bihoreau, MT Bis, JC Blacker, D Boada, M Boerwinkle, E Bonuccelli, U Bosco, P Bossu, P Brayne, C Brice, A Brown, K Buxbaum, JD Caffarra, P Campion, D Cantwell, LB Carrasquillo, MM Choi, SH Chouraki, V Clarimon, J Clarke, R Collinge, J Combarros, O Coto, E Craig, D Crane, PK Cruchaga, C Dartigues, JF De Jager, PL DeStefano, AL Del Zompo, M Denning, N Deramecourt, V Dufouil, C Dunstan, ML Eiriksdottir, G Escott-Price, V Evans, D Faber, KM Farrer, LA Fievet, N Fitzpatrick, AL Foroud, TM Fox, NC Frank-Garcia, A Fratiglioni, L Galimberti, D Gallacher, J Garcia, FS Gerrish, A Gill, M Goate, AM Graff, C Grenier-Boley, B Gu, W Gudnason, V Haines, JL Hakonarson, H Hamilton-Nelson, KL Hampel, H Hannequin, D Hanon, O Hardy, J Harold, D Harris, TB Hernandez, I Hiltunen, M Hofman, A Hollingworth, P Holmans, P Holmes, C Huentelman, MJ Ibrahim-Verbaas, CA Ikram, MA Ingelsson, M Johnson, AD Johnston, JA Jones, L Jonsson, PV Jun, G Kamatani, Y Kamboh, MI Kauwe, JSK Keller, L Kukull, WA Kunkle, B Lambert, JC Lannfelt, L Larson, EB Lathrop, M Launer, LJ Letenneur, L Lin, CF Lleo, A Lopez, OL Love, S Lovestone, S Lunetta, KL Maier, W Mancuso, M Martin, ER Mateo, I Mayeux, R Mayhaus, M McGuinness, B Mead, S Mecocci, P Moebus, S Montine, TJ Morgan, K Mosley, TH Myers, AJ Nacmias, B Naj, AC Nalls, MA Naranjo, MCD Nothen, MM O'Donovan, MC Owen, MJ Panza, F Pasquier, F Passmore, P Pastor, P Pericak-Vance, MA Perry, W Pichler, S Pilotto, A Powell, JF Proitsi, P Psaty, BM Ramirez, A Razquin, C Reitz, C Richards, A Riemenschneider, M Ritchie, K Rogaeva, E Rotter, JI Rubinsztein, DC Ruiz, A Rujescu, D Russo, G Scarpini, E Schellenberg, GD Schmidt, H Schmidt, R Seshadri, S Siciliano, G Sims, R Sleegers, K Smith, AV Soininen, H Solfrizzi, V Sorbi, S Spalletta, G St George-Hyslop, P Thomas, C Thornton-Wells, TA Todd, S Tsolaki, M Tsuang, DW Tzourio, C Valladares, O Van Broeckhoven, C Vardarajan, BN Vedernikov, A Vronskaya, M Wallon, D Wang, LS Williams, J Younkin, SG Yu, L Zelenika, D Zou, FG de Bruijn, RFAG van Duijn, CM |
| author_facet | Escott-Price, V Bellenguez, C Wang, LS Choi, SH Harold, D Jones, L Holmans, P Gerrish, A Vedernikov, A Richards, A DeStefano, AL Lambert, JC Ibrahim-Verbaas, CA Naj, AC Sims, R Jun, G Bis, JC Beecham, GW Grenier-Boley, B Russo, G Thornton-Wells, TA Denning, N Smith, AV Chouraki, V Thomas, C Ikram, MA Zelenika, D Vardarajan, BN Kamatani, Y Lin, CF Schmidt, H Kunkle, B Dunstan, ML Vronskaya, M Johnson, AD Ruiz, A Bihoreau, MT Reitz, C Pasquier, F Hollingworth, P Hanon, O Fitzpatrick, AL Buxbaum, JD Campion, D Crane, PK Baldwin, C Becker, T Gudnason, V Cruchaga, C Craig, D Amin, N Berr, C Lopez, OL De Jager, PL Deramecourt, V Johnston, JA Evans, D Lovestone, S Letenneur, L Hernandez, I Rubinsztein, DC Eiriksdottir, G Sleegers, K Goate, AM Fievet, N Huentelman, MJ Gill, M Brown, K Kamboh, MI Keller, L Barberger-Gateau, P McGuinness, B Larson, EB Myers, AJ Dufouil, C Todd, S Wallon, D Love, S Rogaeva, E Gallacher, J St George-Hyslop, P Clarimon, J Lleo, A Bayer, A Tsuang, DW Yu, L Tsolaki, M Bossu, P Spalletta, G Proitsi, P Collinge, J Sorbi, S Garcia, FS Fox, NC Hardy, J Naranjo, MCD Bosco, P Clarke, R Brayne, C Galimberti, D Scarpini, E Bonuccelli, U Mancuso, M Siciliano, G Moebus, S Mecocci, P Del Zompo, M Maier, W Hampel, H Pilotto, A Frank-Garcia, A Panza, F Solfrizzi, V Caffarra, P Nacmias, B Perry, W Mayhaus, M Lannfelt, L Hakonarson, H Pichler, S Carrasquillo, MM Ingelsson, M Beekly, D Alvarez, V Zou, FG Valladares, O Younkin, SG Coto, E Hamilton-Nelson, KL Gu, W Razquin, C Pastor, P Mateo, I Owen, MJ Faber, KM Jonsson, PV Combarros, O O'Donovan, MC Cantwell, LB Soininen, H Blacker, D Mead, S Mosley, TH Bennett, DA Harris, TB Fratiglioni, L Holmes, C de Bruijn, RFAG Passmore, P Montine, TJ Bettens, K Rotter, JI Brice, A Morgan, K Foroud, TM Kukull, WA Hannequin, D Powell, JF Nalls, MA Ritchie, K Lunetta, KL Kauwe, JSK Boerwinkle, E Riemenschneider, M Boada, M Hiltunen, M Martin, ER Schmidt, R Rujescu, D Dartigues, JF Mayeux, R Tzourio, C Hofman, A Nothen, MM Graff, C Psaty, BM Haines, JL Lathrop, M Pericak-Vance, MA Launer, LJ Van Broeckhoven, C Farrer, LA van Duijn, CM Ramirez, A Seshadri, S Schellenberg, GD Amouyel, P Williams, J |
| author_role | author |
| collection | r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau |
| description | Background: Alzheimer's disease is a common debilitating dementia with known heritability, for which 20 late onset susceptibility loci have been identified, but more remain to be discovered. This study sought to identify new susceptibility genes, using an alternative gene-wide analytical approach which tests for patterns of association within genes, in the powerful genome-wide association dataset of the International Genomics of Alzheimer's Project Consortium, comprising over 7 m genotypes from 25,580 Alzheimer's cases and 48,466 controls. Principal Findings: In addition to earlier reported genes, we detected genome-wide significant loci on chromosomes 8 (TP53INP1, p = 1.4x10(-6)) and 14 (IGHV1-67 p = 7.9x10(-8)) which indexed novel susceptibility loci. Significance: The additional genes identified in this study, have an array of functions previously implicated in Alzheimer's disease, including aspects of energy metabolism, protein degradation and the immune system and add further weight to these pathways as potential therapeutic targets in Alzheimer's disease. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_c4aa6916f9e9dd75d09c45de8ae22abc |
| institution | Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau) |
| instname_str | Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau) |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:iibsantpau.fundanetsuite.com:p8909 |
| publishDate | 2014 |
| publishDateSort | 2014 |
| publisher | PUBLIC LIBRARY SCIENCE |
| publisherStr | PUBLIC LIBRARY SCIENCE |
| reponame_str | r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau |
| spelling | Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease Escott-Price, V Bellenguez, C Wang, LS Choi, SH Harold, D Jones, L Holmans, P Gerrish, A Vedernikov, A Richards, A DeStefano, AL Lambert, JC Ibrahim-Verbaas, CA Naj, AC Sims, R Jun, G Bis, JC Beecham, GW Grenier-Boley, B Russo, G Thornton-Wells, TA Denning, N Smith, AV Chouraki, V Thomas, C Ikram, MA Zelenika, D Vardarajan, BN Kamatani, Y Lin, CF Schmidt, H Kunkle, B Dunstan, ML Vronskaya, M Johnson, AD Ruiz, A Bihoreau, MT Reitz, C Pasquier, F Hollingworth, P Hanon, O Fitzpatrick, AL Buxbaum, JD Campion, D Crane, PK Baldwin, C Becker, T Gudnason, V Cruchaga, C Craig, D Amin, N Berr, C Lopez, OL De Jager, PL Deramecourt, V Johnston, JA Evans, D Lovestone, S Letenneur, L Hernandez, I Rubinsztein, DC Eiriksdottir, G Sleegers, K Goate, AM Fievet, N Huentelman, MJ Gill, M Brown, K Kamboh, MI Keller, L Barberger-Gateau, P McGuinness, B Larson, EB Myers, AJ Dufouil, C Todd, S Wallon, D Love, S Rogaeva, E Gallacher, J St George-Hyslop, P Clarimon, J Lleo, A Bayer, A Tsuang, DW Yu, L Tsolaki, M Bossu, P Spalletta, G Proitsi, P Collinge, J Sorbi, S Garcia, FS Fox, NC Hardy, J Naranjo, MCD Bosco, P Clarke, R Brayne, C Galimberti, D Scarpini, E Bonuccelli, U Mancuso, M Siciliano, G Moebus, S Mecocci, P Del Zompo, M Maier, W Hampel, H Pilotto, A Frank-Garcia, A Panza, F Solfrizzi, V Caffarra, P Nacmias, B Perry, W Mayhaus, M Lannfelt, L Hakonarson, H Pichler, S Carrasquillo, MM Ingelsson, M Beekly, D Alvarez, V Zou, FG Valladares, O Younkin, SG Coto, E Hamilton-Nelson, KL Gu, W Razquin, C Pastor, P Mateo, I Owen, MJ Faber, KM Jonsson, PV Combarros, O O'Donovan, MC Cantwell, LB Soininen, H Blacker, D Mead, S Mosley, TH Bennett, DA Harris, TB Fratiglioni, L Holmes, C de Bruijn, RFAG Passmore, P Montine, TJ Bettens, K Rotter, JI Brice, A Morgan, K Foroud, TM Kukull, WA Hannequin, D Powell, JF Nalls, MA Ritchie, K Lunetta, KL Kauwe, JSK Boerwinkle, E Riemenschneider, M Boada, M Hiltunen, M Martin, ER Schmidt, R Rujescu, D Dartigues, JF Mayeux, R Tzourio, C Hofman, A Nothen, MM Graff, C Psaty, BM Haines, JL Lathrop, M Pericak-Vance, MA Launer, LJ Van Broeckhoven, C Farrer, LA van Duijn, CM Ramirez, A Seshadri, S Schellenberg, GD Amouyel, P Williams, J Background: Alzheimer's disease is a common debilitating dementia with known heritability, for which 20 late onset susceptibility loci have been identified, but more remain to be discovered. This study sought to identify new susceptibility genes, using an alternative gene-wide analytical approach which tests for patterns of association within genes, in the powerful genome-wide association dataset of the International Genomics of Alzheimer's Project Consortium, comprising over 7 m genotypes from 25,580 Alzheimer's cases and 48,466 controls. Principal Findings: In addition to earlier reported genes, we detected genome-wide significant loci on chromosomes 8 (TP53INP1, p = 1.4x10(-6)) and 14 (IGHV1-67 p = 7.9x10(-8)) which indexed novel susceptibility loci. Significance: The additional genes identified in this study, have an array of functions previously implicated in Alzheimer's disease, including aspects of energy metabolism, protein degradation and the immune system and add further weight to these pathways as potential therapeutic targets in Alzheimer's disease. PUBLIC LIBRARY SCIENCE https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=8909 |
| spellingShingle | Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease Escott-Price, V |
| status_str | publishedVersion |
| title | Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease |
| title_full | Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease |
| title_fullStr | Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease |
| title_full_unstemmed | Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease |
| title_short | Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease |
| title_sort | Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease |
| url | https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=8909 |