MHC class I diversity in chimpanzees and bonobos
Major histocompatibility complex (MHC) class I genes are critically involved in the defense against intracellular pathogens. MHC diversity comparisons among samples of closely related taxa may reveal traces of past or ongoing selective processes. The bonobo and chimpanzee are the closest living evol...
| Autores: | ; ; ; ; |
|---|---|
| Tipo de documento: | Artículo |
| Estado: | Published version |
| Fecha de publicación: | 2017 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:10230/33346 |
| Acceso en línea: | http://hdl.handle.net/10230/33346 http://dx.doi.org/10.1007/s00251-017-0990-x |
| Nivel de acceso: | Acceso abierto |
| Palabra clave: | Pan troglodytes Pan paniscus PacBio Great apes Next-generation sequencing |
| _version_ | 1878739593964027904 |
|---|---|
| author | Maibach, Vincent |
| author2 | Hans, Jörg B. Hvilsom, Christina Marquès i Bonet, Tomàs, 1975- Vigilant, Linda |
| author2_role | author author author author |
| author_browse | Hans, Jörg B. Hvilsom, Christina Maibach, Vincent Marquès i Bonet, Tomàs, 1975- Vigilant, Linda |
| author_facet | Maibach, Vincent Hans, Jörg B. Hvilsom, Christina Marquès i Bonet, Tomàs, 1975- Vigilant, Linda |
| author_role | author |
| collection | Recercat. Dipósit de la Recerca de Catalunya |
| description | Major histocompatibility complex (MHC) class I genes are critically involved in the defense against intracellular pathogens. MHC diversity comparisons among samples of closely related taxa may reveal traces of past or ongoing selective processes. The bonobo and chimpanzee are the closest living evolutionary relatives of humans and last shared a common ancestor some 1 mya. However, little is known concerning MHC class I diversity in bonobos or in central chimpanzees, the most numerous and genetically diverse chimpanzee subspecies. Here, we used a long-read sequencing technology (PacBio) to sequence the classical MHC class I genes A, B, C, and A-like in 20 and 30 wild-born bonobos and chimpanzees, respectively, with a main focus on central chimpanzees to assess and compare diversity in those two species. We describe in total 21 and 42 novel coding region sequences for the two species, respectively. In addition, we found evidence for a reduced MHC class I diversity in bonobos as compared to central chimpanzees as well as to western chimpanzees and humans. The reduced bonobo MHC class I diversity may be the result of a selective process in their evolutionary past since their split from chimpanzees. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_c46d7fd1cbe89cf0f6416a9ce6765a7b |
| institution | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| instname_str | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:recercat.cat:10230/33346 |
| publishDate | 2017 |
| publishDateSort | 2017 |
| publisher | Springer |
| publisherStr | Springer |
| reponame_str | Recercat. Dipósit de la Recerca de Catalunya |
| spelling | MHC class I diversity in chimpanzees and bonobos Maibach, Vincent Hans, Jörg B. Hvilsom, Christina Marquès i Bonet, Tomàs, 1975- Vigilant, Linda Pan troglodytes Pan paniscus PacBio Great apes Next-generation sequencing Major histocompatibility complex (MHC) class I genes are critically involved in the defense against intracellular pathogens. MHC diversity comparisons among samples of closely related taxa may reveal traces of past or ongoing selective processes. The bonobo and chimpanzee are the closest living evolutionary relatives of humans and last shared a common ancestor some 1 mya. However, little is known concerning MHC class I diversity in bonobos or in central chimpanzees, the most numerous and genetically diverse chimpanzee subspecies. Here, we used a long-read sequencing technology (PacBio) to sequence the classical MHC class I genes A, B, C, and A-like in 20 and 30 wild-born bonobos and chimpanzees, respectively, with a main focus on central chimpanzees to assess and compare diversity in those two species. We describe in total 21 and 42 novel coding region sequences for the two species, respectively. In addition, we found evidence for a reduced MHC class I diversity in bonobos as compared to central chimpanzees as well as to western chimpanzees and humans. The reduced bonobo MHC class I diversity may be the result of a selective process in their evolutionary past since their split from chimpanzees. Springer http://hdl.handle.net/10230/33346 http://dx.doi.org/10.1007/s00251-017-0990-x |
| spellingShingle | MHC class I diversity in chimpanzees and bonobos Maibach, Vincent Pan troglodytes Pan paniscus PacBio Great apes Next-generation sequencing |
| status_str | publishedVersion |
| title | MHC class I diversity in chimpanzees and bonobos |
| title_full | MHC class I diversity in chimpanzees and bonobos |
| title_fullStr | MHC class I diversity in chimpanzees and bonobos |
| title_full_unstemmed | MHC class I diversity in chimpanzees and bonobos |
| title_short | MHC class I diversity in chimpanzees and bonobos |
| title_sort | MHC class I diversity in chimpanzees and bonobos |
| topic | Pan troglodytes Pan paniscus PacBio Great apes Next-generation sequencing |
| topic_facet | Pan troglodytes Pan paniscus PacBio Great apes Next-generation sequencing |
| url | http://hdl.handle.net/10230/33346 http://dx.doi.org/10.1007/s00251-017-0990-x |