Current Trends in organ preservation solutions for pancreas transplantation; a single.center retrospective study
Due to the high vulnerability of the pancreas to ischemia-reperfusion injury, choices regarding preservation solution markedly affect pancreas transplant success. A retrospective single-center analysis of 380 pancreas transplants (2000-2019) was performed to correlate current preservation solutions...
| Authors: | ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; |
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| Format: | Article |
| Status: | Published version |
| Publication date: | 2022 |
| Country: | España |
| Institution: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repository: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/185546 |
| Online Access: | https://hdl.handle.net/2445/185546 |
| Access Level: | Open access |
| Keyword: | Trasplantament d'òrgans Conservació d'òrgans Pàncrees Transplantation of organs Preservation of organs Pancreas |
| _version_ | 1878739443221790720 |
|---|---|
| author | Ferrer Fábrega, Joana |
| author2 | Folch i Puy, Emma Lozano Salvatella, Juan José Ventura Aguiar, Pedro Cárdenas, Gabriel Paredes, David García Criado, Ángeles Bombí, Josep Antoni García Pérez, Rocío López Boado, Miguel Ángel Rull, Ramón Esmatjes Mompó, Enric Ricart Brulles, Ma. José Diekmann, Fritz Fondevila Campo, Constantino Fernández Cruz, Laureano Fuster Obregón, Josep García-Valdecasas Salgado, Juan Carlos |
| author2_role | author author author author author author author author author author author author author author author author author |
| author_browse | Bombí, Josep Antoni Cárdenas, Gabriel Diekmann, Fritz Esmatjes Mompó, Enric Fernández Cruz, Laureano Ferrer Fábrega, Joana Folch i Puy, Emma Fondevila Campo, Constantino Fuster Obregón, Josep García Criado, Ángeles García Pérez, Rocío García-Valdecasas Salgado, Juan Carlos Lozano Salvatella, Juan José López Boado, Miguel Ángel Paredes, David Ricart Brulles, Ma. José Rull, Ramón Ventura Aguiar, Pedro |
| author_facet | Ferrer Fábrega, Joana Folch i Puy, Emma Lozano Salvatella, Juan José Ventura Aguiar, Pedro Cárdenas, Gabriel Paredes, David García Criado, Ángeles Bombí, Josep Antoni García Pérez, Rocío López Boado, Miguel Ángel Rull, Ramón Esmatjes Mompó, Enric Ricart Brulles, Ma. José Diekmann, Fritz Fondevila Campo, Constantino Fernández Cruz, Laureano Fuster Obregón, Josep García-Valdecasas Salgado, Juan Carlos |
| author_role | author |
| collection | Recercat. Dipósit de la Recerca de Catalunya |
| description | Due to the high vulnerability of the pancreas to ischemia-reperfusion injury, choices regarding preservation solution markedly affect pancreas transplant success. A retrospective single-center analysis of 380 pancreas transplants (2000-2019) was performed to correlate current preservation solutions with transplant outcomes. Early graft failure requiring transplantectomy within 30 days post-transplant occurred in 7.5% for University of Wisconsin (UW) group (n = 267), 10.8% of Celsior (CS) group (n = 83), 28.5% of Histidine-Tryptophan-Ketoglutarate (HTK) group (n = 7), and none for Institut Georges Lopez-1 (IGL-1) group (n = 23). The most common causes of technical failures in this cohort included abdominal hemorrhage (8.4%); graft pancreatitis (3.7%); fluid collections (2.6%); intestinal complications (6.6%); and vascular thrombosis (20.5%). Although IGL-1 solution provided lower surgical complication rates, no significant differences were found between studied groups. Nevertheless, HTK solution was associated with elevated pancreatitis rates. The best graft survival was achieved at 1 year using UW and IGL-1, and at 3 and 5 years using IGL-1 (p = 0.017). There were no significant differences in patient survival after a median follow-up of 118.4 months. In this setting therefore, IGL-1solution appears promising for perfusion and organ preservation in clinical pancreas transplantation, compared to other commonly used solutions. Keywords: pancreas transplantation, graft survival, preservation solution, ischemia-reperfusion, pancreatitis, |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_c19a1d03330e679060e0fcbf3ec3c3d4 |
| institution | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| instname_str | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:recercat.cat:2445/185546 |
| publishDate | 2022 |
| publishDateSort | 2022 |
| publisher | Frontiers Media |
| publisherStr | Frontiers Media |
| reponame_str | Recercat. Dipósit de la Recerca de Catalunya |
| spelling | Current Trends in organ preservation solutions for pancreas transplantation; a single.center retrospective study Ferrer Fábrega, Joana Folch i Puy, Emma Lozano Salvatella, Juan José Ventura Aguiar, Pedro Cárdenas, Gabriel Paredes, David García Criado, Ángeles Bombí, Josep Antoni García Pérez, Rocío López Boado, Miguel Ángel Rull, Ramón Esmatjes Mompó, Enric Ricart Brulles, Ma. José Diekmann, Fritz Fondevila Campo, Constantino Fernández Cruz, Laureano Fuster Obregón, Josep García-Valdecasas Salgado, Juan Carlos Trasplantament d'òrgans Conservació d'òrgans Pàncrees Transplantation of organs Preservation of organs Pancreas Due to the high vulnerability of the pancreas to ischemia-reperfusion injury, choices regarding preservation solution markedly affect pancreas transplant success. A retrospective single-center analysis of 380 pancreas transplants (2000-2019) was performed to correlate current preservation solutions with transplant outcomes. Early graft failure requiring transplantectomy within 30 days post-transplant occurred in 7.5% for University of Wisconsin (UW) group (n = 267), 10.8% of Celsior (CS) group (n = 83), 28.5% of Histidine-Tryptophan-Ketoglutarate (HTK) group (n = 7), and none for Institut Georges Lopez-1 (IGL-1) group (n = 23). The most common causes of technical failures in this cohort included abdominal hemorrhage (8.4%); graft pancreatitis (3.7%); fluid collections (2.6%); intestinal complications (6.6%); and vascular thrombosis (20.5%). Although IGL-1 solution provided lower surgical complication rates, no significant differences were found between studied groups. Nevertheless, HTK solution was associated with elevated pancreatitis rates. The best graft survival was achieved at 1 year using UW and IGL-1, and at 3 and 5 years using IGL-1 (p = 0.017). There were no significant differences in patient survival after a median follow-up of 118.4 months. In this setting therefore, IGL-1solution appears promising for perfusion and organ preservation in clinical pancreas transplantation, compared to other commonly used solutions. Keywords: pancreas transplantation, graft survival, preservation solution, ischemia-reperfusion, pancreatitis, Frontiers Media https://hdl.handle.net/2445/185546 |
| spellingShingle | Current Trends in organ preservation solutions for pancreas transplantation; a single.center retrospective study Ferrer Fábrega, Joana Trasplantament d'òrgans Conservació d'òrgans Pàncrees Transplantation of organs Preservation of organs Pancreas |
| status_str | publishedVersion |
| title | Current Trends in organ preservation solutions for pancreas transplantation; a single.center retrospective study |
| title_full | Current Trends in organ preservation solutions for pancreas transplantation; a single.center retrospective study |
| title_fullStr | Current Trends in organ preservation solutions for pancreas transplantation; a single.center retrospective study |
| title_full_unstemmed | Current Trends in organ preservation solutions for pancreas transplantation; a single.center retrospective study |
| title_short | Current Trends in organ preservation solutions for pancreas transplantation; a single.center retrospective study |
| title_sort | Current Trends in organ preservation solutions for pancreas transplantation; a single.center retrospective study |
| topic | Trasplantament d'òrgans Conservació d'òrgans Pàncrees Transplantation of organs Preservation of organs Pancreas |
| topic_facet | Trasplantament d'òrgans Conservació d'òrgans Pàncrees Transplantation of organs Preservation of organs Pancreas |
| url | https://hdl.handle.net/2445/185546 |