Maternal plasma antioxidant status in the first trimester of pregnancy and development of obstetric complications
Oxidative stress is present in pregnancy complications. However, it is unknown if early maternal antioxidant status could influence later development of complications. The use of assisted reproduction techniques (ART) is rising due to the delay of first pregnancy and there is scarce information on i...
| Authors: | ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; |
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| Format: | Article |
| Publication date: | 2016 |
| Country: | España |
| Institution: | Universidad Autónoma de Madrid |
| Repository: | Biblos-e Archivo. Repositorio Institucional de la UAM |
| Language: | English |
| OAI Identifier: | oai:repositorio.uam.es:10486/690823 |
| Online Access: | http://hdl.handle.net/10486/690823 https://dx.doi.org/10.1016/j.placenta.2016.08.090 |
| Access Level: | Open access |
| Keyword: | Antioxidants Obstetric complications Plasma Pregnancy Biomarker Medicina |
| _version_ | 1878739219886637056 |
|---|---|
| author | Ramiro Cortijo, David |
| author2 | Herrera, Teresa Rodríguez Rodríguez, Pilar López de Pablo León, Ángel Luis Calle Fernández-Miranda, María de la López Giménez, Rosario Mora Urda, Ana Isabel Gutiérrez-Arzapalo, Perla Y. Gómez-Rioja, Rubén Aguilera Gutiérrez, Yolanda Martín Cabrejas, M. Ángeles Condezo-Hoyos, Luis González Enguita, María del Carmen Montero López, María del Pilar Moreno Jiménez, Bernardo Arribas Rodríguez, Silvia Magdalena |
| author2_role | author author author author author author author author author author author author author author author |
| author_browse | Aguilera Gutiérrez, Yolanda Arribas Rodríguez, Silvia Magdalena Calle Fernández-Miranda, María de la Condezo-Hoyos, Luis González Enguita, María del Carmen Gutiérrez-Arzapalo, Perla Y. Gómez-Rioja, Rubén Herrera, Teresa López Giménez, Rosario López de Pablo León, Ángel Luis Martín Cabrejas, M. Ángeles Montero López, María del Pilar Mora Urda, Ana Isabel Moreno Jiménez, Bernardo Ramiro Cortijo, David Rodríguez Rodríguez, Pilar |
| author_facet | Ramiro Cortijo, David Herrera, Teresa Rodríguez Rodríguez, Pilar López de Pablo León, Ángel Luis Calle Fernández-Miranda, María de la López Giménez, Rosario Mora Urda, Ana Isabel Gutiérrez-Arzapalo, Perla Y. Gómez-Rioja, Rubén Aguilera Gutiérrez, Yolanda Martín Cabrejas, M. Ángeles Condezo-Hoyos, Luis González Enguita, María del Carmen Montero López, María del Pilar Moreno Jiménez, Bernardo Arribas Rodríguez, Silvia Magdalena |
| author_role | author |
| collection | Biblos-e Archivo. Repositorio Institucional de la UAM |
| description | Oxidative stress is present in pregnancy complications. However, it is unknown if early maternal antioxidant status could influence later development of complications. The use of assisted reproduction techniques (ART) is rising due to the delay of first pregnancy and there is scarce information on its influence on oxidative balance. Objective To assess the possible relationship between maternal plasma antioxidant status in first trimester of gestation with later development of pregnancy complications, evaluating the influence of ART and nutrition. Methods Plasma from 98 healthy pregnant women was obtained at week 10, nutrition questionnaires filled and women were followed until delivery. We evaluated biomarkers of oxidative damage (carbonyls, malondialdehyde-MDA), antioxidants (thiols, reduced glutathione, phenolic compounds, catalase and superoxide dismutase activities) by spectrophotometry/fluorimetry and melatonin (ELISA). Antioxidant status score (Antiox-S) was calculated as the computation of antioxidants. Diet-antioxidants relationship was evaluated through multiple correspondence analysis. Results Melatonin and carbonyls exhibited a negative correlation. No difference in oxidative damage was found between groups, but Antiox-S was significantly lower in women who developed complications. No differences in oxidative damage or Antiox-S were found between ART and no-ART pregnancies. High consumption of foods of vegetable origin cluster with high plasma levels of phenolic compounds and with high Antiox-S. Conclusions In early normal gestation, low plasma antioxidant status, assessed through a global score, associates with later development of pregnancy complications. Larger population studies could help to determine the value of Antiox-S as predictive tool and the relevance of nutrition on maternal antioxidant status |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_bd59ccf2e9ef4a5aab8b4e75aef01d7a |
| institution | Universidad Autónoma de Madrid |
| instname_str | Universidad Autónoma de Madrid |
| language | eng |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:repositorio.uam.es:10486/690823 |
| publishDate | 2016 |
| publishDateSort | 2016 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| reponame_str | Biblos-e Archivo. Repositorio Institucional de la UAM |
| spelling | Maternal plasma antioxidant status in the first trimester of pregnancy and development of obstetric complications Ramiro Cortijo, David Herrera, Teresa Rodríguez Rodríguez, Pilar López de Pablo León, Ángel Luis Calle Fernández-Miranda, María de la López Giménez, Rosario Mora Urda, Ana Isabel Gutiérrez-Arzapalo, Perla Y. Gómez-Rioja, Rubén Aguilera Gutiérrez, Yolanda Martín Cabrejas, M. Ángeles Condezo-Hoyos, Luis González Enguita, María del Carmen Montero López, María del Pilar Moreno Jiménez, Bernardo Arribas Rodríguez, Silvia Magdalena Antioxidants Obstetric complications Plasma Pregnancy Biomarker Medicina Oxidative stress is present in pregnancy complications. However, it is unknown if early maternal antioxidant status could influence later development of complications. The use of assisted reproduction techniques (ART) is rising due to the delay of first pregnancy and there is scarce information on its influence on oxidative balance. Objective To assess the possible relationship between maternal plasma antioxidant status in first trimester of gestation with later development of pregnancy complications, evaluating the influence of ART and nutrition. Methods Plasma from 98 healthy pregnant women was obtained at week 10, nutrition questionnaires filled and women were followed until delivery. We evaluated biomarkers of oxidative damage (carbonyls, malondialdehyde-MDA), antioxidants (thiols, reduced glutathione, phenolic compounds, catalase and superoxide dismutase activities) by spectrophotometry/fluorimetry and melatonin (ELISA). Antioxidant status score (Antiox-S) was calculated as the computation of antioxidants. Diet-antioxidants relationship was evaluated through multiple correspondence analysis. Results Melatonin and carbonyls exhibited a negative correlation. No difference in oxidative damage was found between groups, but Antiox-S was significantly lower in women who developed complications. No differences in oxidative damage or Antiox-S were found between ART and no-ART pregnancies. High consumption of foods of vegetable origin cluster with high plasma levels of phenolic compounds and with high Antiox-S. Conclusions In early normal gestation, low plasma antioxidant status, assessed through a global score, associates with later development of pregnancy complications. Larger population studies could help to determine the value of Antiox-S as predictive tool and the relevance of nutrition on maternal antioxidant status Elsevier http://hdl.handle.net/10486/690823 https://dx.doi.org/10.1016/j.placenta.2016.08.090 |
| spellingShingle | Maternal plasma antioxidant status in the first trimester of pregnancy and development of obstetric complications Ramiro Cortijo, David Antioxidants Obstetric complications Plasma Pregnancy Biomarker Medicina |
| title | Maternal plasma antioxidant status in the first trimester of pregnancy and development of obstetric complications |
| title_full | Maternal plasma antioxidant status in the first trimester of pregnancy and development of obstetric complications |
| title_fullStr | Maternal plasma antioxidant status in the first trimester of pregnancy and development of obstetric complications |
| title_full_unstemmed | Maternal plasma antioxidant status in the first trimester of pregnancy and development of obstetric complications |
| title_short | Maternal plasma antioxidant status in the first trimester of pregnancy and development of obstetric complications |
| title_sort | Maternal plasma antioxidant status in the first trimester of pregnancy and development of obstetric complications |
| topic | Antioxidants Obstetric complications Plasma Pregnancy Biomarker Medicina |
| topic_facet | Antioxidants Obstetric complications Plasma Pregnancy Biomarker Medicina |
| url | http://hdl.handle.net/10486/690823 https://dx.doi.org/10.1016/j.placenta.2016.08.090 |