Cocoa diet and antibody immune response in preclinical studies
The ability of cocoa to interact with the immune system in vitro and in vivo has been described. In the latter context, a cocoa-enriched diet in healthy rats was able to modify the immune system's functionality. This fact could be observed in the composition and functionality of lymphoid tissues, su...
| Authors: | ; ; ; ; ; |
|---|---|
| Format: | Article |
| Status: | Published version |
| Publication date: | 2017 |
| Country: | España |
| Institution: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repository: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/124529 |
| Online Access: | https://hdl.handle.net/2445/124529 |
| Access Level: | Open access |
| Keyword: | Dieta Cacau Sistema immunològic Diet Cocoa Immune system |
| _version_ | 1878739131156135936 |
|---|---|
| author | Camps i Bossacoma, Mariona |
| author2 | Massot Cladera, Malen Abril Gil, Maria del Mar Franch i Masferrer, Àngels Pérez-Cano, Francisco J. Castell, Margarida |
| author2_role | author author author author author |
| author_browse | Abril Gil, Maria del Mar Camps i Bossacoma, Mariona Castell, Margarida Franch i Masferrer, Àngels Massot Cladera, Malen Pérez-Cano, Francisco J. |
| author_facet | Camps i Bossacoma, Mariona Massot Cladera, Malen Abril Gil, Maria del Mar Franch i Masferrer, Àngels Pérez-Cano, Francisco J. Castell, Margarida |
| author_role | author |
| collection | Recercat. Dipósit de la Recerca de Catalunya |
| description | The ability of cocoa to interact with the immune system in vitro and in vivo has been described. In the latter context, a cocoa-enriched diet in healthy rats was able to modify the immune system's functionality. This fact could be observed in the composition and functionality of lymphoid tissues, such as the thymus, spleen, and lymph nodes. Consequently, immune effector mechanisms, such as antibody synthesis, were modified. A cocoa-enriched diet in young rats was able to attenuate the serum levels of immunoglobulin (Ig) G, IgM, and IgA and also the intestinal IgM and IgA secretion. Moreover, in immunized rats, the intake of cocoa decreased specific IgG1, IgG2a, IgG2c, and IgM concentrations in serum. This immune-regulator potential was then tested in disease models in which antibodies play a pathogenic role. A cocoa-enriched diet was able to partially prevent the synthesis of autoantibodies in a model of autoimmune arthritis in rats and was also able to protect against IgE and T helper 2-related antibody synthesis in two rat models of allergy. Likewise, a cocoa-enriched diet prevented an oral sensitization process in young rats. In this review, we will focus on the influence of cocoa on the acquired branch of the immune function. Therefore, we will focus on how a cocoa diet influences lymphocyte function both in the systemic and intestinal immune system. Likewise, its potential role in preventing some antibody-induced immune diseases is also included. Although further studies must characterize the particular cocoa components responsible for such effects and nutritional studies in humans need to be carried out, cocoa has potential as a nutraceutical agent in some hypersensitivity status. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_bbb1332e5d91bce00a72933bbaa5ddd0 |
| institution | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| instname_str | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:recercat.cat:2445/124529 |
| publishDate | 2017 |
| publishDateSort | 2017 |
| publisher | Frontiers Media |
| publisherStr | Frontiers Media |
| reponame_str | Recercat. Dipósit de la Recerca de Catalunya |
| spelling | Cocoa diet and antibody immune response in preclinical studies Camps i Bossacoma, Mariona Massot Cladera, Malen Abril Gil, Maria del Mar Franch i Masferrer, Àngels Pérez-Cano, Francisco J. Castell, Margarida Dieta Cacau Sistema immunològic Diet Cocoa Immune system The ability of cocoa to interact with the immune system in vitro and in vivo has been described. In the latter context, a cocoa-enriched diet in healthy rats was able to modify the immune system's functionality. This fact could be observed in the composition and functionality of lymphoid tissues, such as the thymus, spleen, and lymph nodes. Consequently, immune effector mechanisms, such as antibody synthesis, were modified. A cocoa-enriched diet in young rats was able to attenuate the serum levels of immunoglobulin (Ig) G, IgM, and IgA and also the intestinal IgM and IgA secretion. Moreover, in immunized rats, the intake of cocoa decreased specific IgG1, IgG2a, IgG2c, and IgM concentrations in serum. This immune-regulator potential was then tested in disease models in which antibodies play a pathogenic role. A cocoa-enriched diet was able to partially prevent the synthesis of autoantibodies in a model of autoimmune arthritis in rats and was also able to protect against IgE and T helper 2-related antibody synthesis in two rat models of allergy. Likewise, a cocoa-enriched diet prevented an oral sensitization process in young rats. In this review, we will focus on the influence of cocoa on the acquired branch of the immune function. Therefore, we will focus on how a cocoa diet influences lymphocyte function both in the systemic and intestinal immune system. Likewise, its potential role in preventing some antibody-induced immune diseases is also included. Although further studies must characterize the particular cocoa components responsible for such effects and nutritional studies in humans need to be carried out, cocoa has potential as a nutraceutical agent in some hypersensitivity status. Frontiers Media https://hdl.handle.net/2445/124529 |
| spellingShingle | Cocoa diet and antibody immune response in preclinical studies Camps i Bossacoma, Mariona Dieta Cacau Sistema immunològic Diet Cocoa Immune system |
| status_str | publishedVersion |
| title | Cocoa diet and antibody immune response in preclinical studies |
| title_full | Cocoa diet and antibody immune response in preclinical studies |
| title_fullStr | Cocoa diet and antibody immune response in preclinical studies |
| title_full_unstemmed | Cocoa diet and antibody immune response in preclinical studies |
| title_short | Cocoa diet and antibody immune response in preclinical studies |
| title_sort | Cocoa diet and antibody immune response in preclinical studies |
| topic | Dieta Cacau Sistema immunològic Diet Cocoa Immune system |
| topic_facet | Dieta Cacau Sistema immunològic Diet Cocoa Immune system |
| url | https://hdl.handle.net/2445/124529 |