Immune cell subpopulations and serum neurofilament light chain are associated with increased risk of disease worsening in multiple sclerosis
Changes is lymphocyte subpopulations in peripheral blood have been proposed as biomarkers for evaluation of disease activity in multiple sclerosis (MS). Serum neurofilament light chain (sNfL) is a biomarker reflecting neuro-axonal injury in MS that could be used to monitor disease activity, response...
| Authors: | ; ; ; ; ; ; ; ; ; ; ; |
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| Format: | Article |
| Status: | Published version |
| Publication date: | 2023 |
| Country: | España |
| Institution: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repository: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:10230/70235 |
| Online Access: | http://hdl.handle.net/10230/70235 http://dx.doi.org/10.1016/j.jneuroim.2023.578175 |
| Access Level: | Open access |
| Keyword: | Multiple sclerosis Serum neurofilament light chain Immune cell subset frequencies Biomarkers Disease worsening |
| _version_ | 1878739131038695425 |
|---|---|
| author | Brune-Ingebretsen, Synne |
| author2 | Høgestøl, Einar A. de Rosbo, Nicole Kerlero Berg-Hansen, Pål Brunborg, Cathrine Blennow, Kaj Zetterberg, Henrik Paul, Friedemann Uccelli, Antonio Villoslada, Pablo Harbo, Hanne F. Berge, Tone |
| author2_role | author author author author author author author author author author author |
| author_browse | Berg-Hansen, Pål Berge, Tone Blennow, Kaj Brunborg, Cathrine Brune-Ingebretsen, Synne Harbo, Hanne F. Høgestøl, Einar A. Paul, Friedemann Uccelli, Antonio Villoslada, Pablo Zetterberg, Henrik de Rosbo, Nicole Kerlero |
| author_facet | Brune-Ingebretsen, Synne Høgestøl, Einar A. de Rosbo, Nicole Kerlero Berg-Hansen, Pål Brunborg, Cathrine Blennow, Kaj Zetterberg, Henrik Paul, Friedemann Uccelli, Antonio Villoslada, Pablo Harbo, Hanne F. Berge, Tone |
| author_role | author |
| collection | Recercat. Dipósit de la Recerca de Catalunya |
| description | Changes is lymphocyte subpopulations in peripheral blood have been proposed as biomarkers for evaluation of disease activity in multiple sclerosis (MS). Serum neurofilament light chain (sNfL) is a biomarker reflecting neuro-axonal injury in MS that could be used to monitor disease activity, response to drugs and to prognosticate disease course. Here we show a moderate correlation between sNfL and lymphocyte cell subpopulations, and our data furthermore suggest that sNfL and specific immune cell subpopulations together could predict future disease worsening in MS. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_bbae4d64a0a5db3be2fd1c7db39de97d |
| institution | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| instname_str | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:recercat.cat:10230/70235 |
| publishDate | 2023 |
| publishDateSort | 2023 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| reponame_str | Recercat. Dipósit de la Recerca de Catalunya |
| spelling | Immune cell subpopulations and serum neurofilament light chain are associated with increased risk of disease worsening in multiple sclerosis Brune-Ingebretsen, Synne Høgestøl, Einar A. de Rosbo, Nicole Kerlero Berg-Hansen, Pål Brunborg, Cathrine Blennow, Kaj Zetterberg, Henrik Paul, Friedemann Uccelli, Antonio Villoslada, Pablo Harbo, Hanne F. Berge, Tone Multiple sclerosis Serum neurofilament light chain Immune cell subset frequencies Biomarkers Disease worsening Changes is lymphocyte subpopulations in peripheral blood have been proposed as biomarkers for evaluation of disease activity in multiple sclerosis (MS). Serum neurofilament light chain (sNfL) is a biomarker reflecting neuro-axonal injury in MS that could be used to monitor disease activity, response to drugs and to prognosticate disease course. Here we show a moderate correlation between sNfL and lymphocyte cell subpopulations, and our data furthermore suggest that sNfL and specific immune cell subpopulations together could predict future disease worsening in MS. This work was supported by the European Commission (ERACOSYSMED ERA-Net program, Sys4MS project, id:43), Instituto de Salud Carlos III, Spain (AC1500052), the Italian Ministry of Health (WFR-PER-2013-02361136), the German Ministry of Science (Deutsches Teilprojekt B “Förderkennzeichen”: 031L0083B), the Norwegian Research Council (project 257955), the South-Eastern Norway Regional Health Authority (project 2019111) and Biogen Norway. Henrik Zetterberg is a Wallenberg Scholar supported by grants from the Swedish Research Council (#2022-01018), the European Union's Horizon Europe research and innovation programme under grant agreement No 101053962, and Swedish State Support for Clinical Research (#ALFGBG-71320). Elsevier http://hdl.handle.net/10230/70235 http://dx.doi.org/10.1016/j.jneuroim.2023.578175 |
| spellingShingle | Immune cell subpopulations and serum neurofilament light chain are associated with increased risk of disease worsening in multiple sclerosis Brune-Ingebretsen, Synne Multiple sclerosis Serum neurofilament light chain Immune cell subset frequencies Biomarkers Disease worsening |
| status_str | publishedVersion |
| title | Immune cell subpopulations and serum neurofilament light chain are associated with increased risk of disease worsening in multiple sclerosis |
| title_full | Immune cell subpopulations and serum neurofilament light chain are associated with increased risk of disease worsening in multiple sclerosis |
| title_fullStr | Immune cell subpopulations and serum neurofilament light chain are associated with increased risk of disease worsening in multiple sclerosis |
| title_full_unstemmed | Immune cell subpopulations and serum neurofilament light chain are associated with increased risk of disease worsening in multiple sclerosis |
| title_short | Immune cell subpopulations and serum neurofilament light chain are associated with increased risk of disease worsening in multiple sclerosis |
| title_sort | Immune cell subpopulations and serum neurofilament light chain are associated with increased risk of disease worsening in multiple sclerosis |
| topic | Multiple sclerosis Serum neurofilament light chain Immune cell subset frequencies Biomarkers Disease worsening |
| topic_facet | Multiple sclerosis Serum neurofilament light chain Immune cell subset frequencies Biomarkers Disease worsening |
| url | http://hdl.handle.net/10230/70235 http://dx.doi.org/10.1016/j.jneuroim.2023.578175 |