Overexpression of canonical prefoldin associates with the risk of mortality and metastasis in non-small cell lung cancer
Canonical prefoldin is a protein cochaperone composed of six di erent subunits (PFDN1 to 6). PFDN1 overexpression promotes epithelial–mesenchymal transition (EMT) and increases the growth of xenograft lung cancer (LC) cell lines. We investigated whether this putative involvement of canonical PFDN in...
| Authors: | ; ; ; ; ; ; ; |
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| Format: | Article |
| Status: | Published version |
| Publication date: | 2020 |
| Country: | España |
| Institution: | Universidad de Sevilla (US) |
| Repository: | idUS. Depósito de Investigación de la Universidad de Sevilla |
| OAI Identifier: | oai:idus.us.es:11441/98291 |
| Online Access: | https://hdl.handle.net/11441/98291 https://doi.org/10.3390/cancers12041052 |
| Access Level: | Open access |
| Keyword: | Prefoldin Metastasis Survival Non-small cell lung cancer |
| _version_ | 1878739117368410112 |
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| author | Peñate Salas, Xenia |
| author2 | Praena Fernández, Juan Manuel Romero Pareja, Pedro Enguix Riego, María del Valle Payán Bravo, Laura Vieites Pérez-Quintela, Begoña Chávez de Diego, Sebastián López Guerra, José Luis |
| author2_role | author author author author author author author |
| author_browse | Chávez de Diego, Sebastián Enguix Riego, María del Valle López Guerra, José Luis Payán Bravo, Laura Peñate Salas, Xenia Praena Fernández, Juan Manuel Romero Pareja, Pedro Vieites Pérez-Quintela, Begoña |
| author_facet | Peñate Salas, Xenia Praena Fernández, Juan Manuel Romero Pareja, Pedro Enguix Riego, María del Valle Payán Bravo, Laura Vieites Pérez-Quintela, Begoña Chávez de Diego, Sebastián López Guerra, José Luis |
| author_role | author |
| collection | idUS. Depósito de Investigación de la Universidad de Sevilla |
| description | Canonical prefoldin is a protein cochaperone composed of six di erent subunits (PFDN1 to 6). PFDN1 overexpression promotes epithelial–mesenchymal transition (EMT) and increases the growth of xenograft lung cancer (LC) cell lines. We investigated whether this putative involvement of canonical PFDN in LC translates into the clinic. First, the mRNA expression of 518 non-small cell LC (NSCLC) cases from The Cancer Genome Atlas (TCGA) database was evaluated. Patients with PFDN1 overexpression had lower overall survival (OS; 45 vs. 86 months; p = 0.034). We then assessed the impact of PFDN expression on outcome in 58 NSCLC patients with available tumor tissue samples. PFDN1, 3, and 5 overexpression were found in 38% (n = 22), 53% (n = 31), and 41% (n = 24) of tumor samples. PFDN1, 3, and 5 overexpression were significantly associated with lower OS, lower disease-free survival (DFS), and lower distant metastasis-free survival (DMFS) for PFDN1 and 3 with a trend for PFDN5. In multivariate analysis, PFDN5 retained significance for OS (hazard ratio (HR) 2.56; p = 0.007) and PFDN1 for DFS (HR 2.53; p = 0.010) and marginally for DMFS (HR 2.32; p = 0.053). Our results indicate that protein response markers, such as PFDN1, 3, and 5, may complement mRNA signatures and be useful for determining the most appropriate therapy for NSCLC patients. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_bb66dfdb31d78bc8900a8ed4bf521574 |
| institution | Universidad de Sevilla (US) |
| instname_str | Universidad de Sevilla (US) |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:idus.us.es:11441/98291 |
| publishDate | 2020 |
| publishDateSort | 2020 |
| reponame_str | idUS. Depósito de Investigación de la Universidad de Sevilla |
| spelling | Overexpression of canonical prefoldin associates with the risk of mortality and metastasis in non-small cell lung cancer Peñate Salas, Xenia Praena Fernández, Juan Manuel Romero Pareja, Pedro Enguix Riego, María del Valle Payán Bravo, Laura Vieites Pérez-Quintela, Begoña Chávez de Diego, Sebastián López Guerra, José Luis Prefoldin Metastasis Survival Non-small cell lung cancer Canonical prefoldin is a protein cochaperone composed of six di erent subunits (PFDN1 to 6). PFDN1 overexpression promotes epithelial–mesenchymal transition (EMT) and increases the growth of xenograft lung cancer (LC) cell lines. We investigated whether this putative involvement of canonical PFDN in LC translates into the clinic. First, the mRNA expression of 518 non-small cell LC (NSCLC) cases from The Cancer Genome Atlas (TCGA) database was evaluated. Patients with PFDN1 overexpression had lower overall survival (OS; 45 vs. 86 months; p = 0.034). We then assessed the impact of PFDN expression on outcome in 58 NSCLC patients with available tumor tissue samples. PFDN1, 3, and 5 overexpression were found in 38% (n = 22), 53% (n = 31), and 41% (n = 24) of tumor samples. PFDN1, 3, and 5 overexpression were significantly associated with lower OS, lower disease-free survival (DFS), and lower distant metastasis-free survival (DMFS) for PFDN1 and 3 with a trend for PFDN5. In multivariate analysis, PFDN5 retained significance for OS (hazard ratio (HR) 2.56; p = 0.007) and PFDN1 for DFS (HR 2.53; p = 0.010) and marginally for DMFS (HR 2.32; p = 0.053). Our results indicate that protein response markers, such as PFDN1, 3, and 5, may complement mRNA signatures and be useful for determining the most appropriate therapy for NSCLC patients. https://hdl.handle.net/11441/98291 https://doi.org/10.3390/cancers12041052 |
| spellingShingle | Overexpression of canonical prefoldin associates with the risk of mortality and metastasis in non-small cell lung cancer Peñate Salas, Xenia Prefoldin Metastasis Survival Non-small cell lung cancer |
| status_str | publishedVersion |
| title | Overexpression of canonical prefoldin associates with the risk of mortality and metastasis in non-small cell lung cancer |
| title_full | Overexpression of canonical prefoldin associates with the risk of mortality and metastasis in non-small cell lung cancer |
| title_fullStr | Overexpression of canonical prefoldin associates with the risk of mortality and metastasis in non-small cell lung cancer |
| title_full_unstemmed | Overexpression of canonical prefoldin associates with the risk of mortality and metastasis in non-small cell lung cancer |
| title_short | Overexpression of canonical prefoldin associates with the risk of mortality and metastasis in non-small cell lung cancer |
| title_sort | Overexpression of canonical prefoldin associates with the risk of mortality and metastasis in non-small cell lung cancer |
| topic | Prefoldin Metastasis Survival Non-small cell lung cancer |
| topic_facet | Prefoldin Metastasis Survival Non-small cell lung cancer |
| url | https://hdl.handle.net/11441/98291 https://doi.org/10.3390/cancers12041052 |