Autologous stem-cell transplantation as consolidation of first-line chemotherapy in patients with peripheral T-cell lymphoma: a multicenter GELTAMO/FIL study
Peripheral T-cell lymphomas (PTCL) are a heterogeneous group of rare lymphoid malignancies that mostly have poor prognoses with currently available treatments. Upfront consolidation with autologous stem cell transplantation (ASCT) is frequently carried out, but its efficacy has never been investigat...
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| Format: | Article |
| Publication date: | 2022 |
| Country: | España |
| Institution: | Universidad de Navarra |
| Repository: | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| Language: | English |
| OAI Identifier: | oai:dnet:dadun_______::154565daf0ef4b4bb2d4dfc2a6329d6e |
| Online Access: | https://hdl.handle.net/10171/124273 |
| Access Level: | Open access |
| Keyword: | Peripheral Lymphomas Autologous Transplantation Survival |
| _version_ | 1878739083298078720 |
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| author | Martín-García-Sancho, A. (Alejandro)|||/items/2740d7f3-f3f9-47e8-a162-1d3ae0b84548 |
| author2 | Bellei, M. (Monica)|||/items/066f8838-ec5c-4121-ad8f-2976d2f946a9 Lopez-Parra, M. (Miriam)|||/items/5e1bb5db-95e6-4107-ab31-89287abeb248 Gritti, G. (Giuseppe)|||/items/9978abb8-e9da-4b73-8705-3d5cec449ce9 Cortés, M. (María)|||/items/f6b827b1-1288-4db3-b09c-e762bab4203d Novelli, S. (Silvana)|||/items/5e682b30-3cca-4110-b8d0-f9a43770d9e4 Panizo, C. (Carlos)|||/items/a5fb9193-be12-418c-9a99-929473b7bb3b Petrucci, L. (Luigi)|||/items/2d1b869f-552b-4598-b07f-632a05466b75 Gutierrez, A. (Antonio)|||/items/cd08206a-1bde-4f25-a9e4-681014c712be Dlouhy, I. (Ivan)|||/items/d63c50e5-0e8f-4129-8c3b-02c6f385905c Bastos-Oreiro, M. (Mariana)|||/items/9798d413-d64d-4b19-b5cf-7987a1d80938 Sancho, J. M. (Juan Manuel)|||/items/11e0ebcf-5625-4b2b-bd95-afd86d626bea Ramírez, M.J. (Maria José)|||/items/3c833d8f-d679-4602-828e-cd218813027a Moraleda, J.M. (Jose Maria)|||/items/6a96c554-773d-428a-9003-41d37bb21477 Carrillo-Cruz, E. (Estrella)|||/items/e7430696-2680-4a72-905a-4e87a3322605 Jiménez-Ubieto, A. (Ana)|||/items/9071b3c8-3ec5-4118-9204-38e17a52f4b5 Jarque, I. (Isidro)|||/items/1dc9f667-92fa-45b6-98dd-401c7ac878e3 Orsucci, L. (Lorella)|||/items/2d616949-b7b7-46f0-9692-646217b3477a Garcia-Torres, E. (Estefania)|||/items/db4f74a4-a769-415a-bc98-2fe0e0ae7ef8 Montalbán, C. (Carlos)|||/items/7c7c01be-65ba-416a-a29b-b05f212c1b27 Dodero, A. (Anna)|||/items/29078649-9179-4f2a-a305-9827711d4b27 Arranz, R. (Reyes)|||/items/497c50e1-0d74-4244-b0a9-fb8a6ec712a5 Heras, N. (Natalia) de las|||/items/f8e78df7-bc72-404d-8122-60fc2976c701 Pascual-Cascon, M.J. (Maria Jesus)|||/items/f0290602-545e-4756-b526-32b6d56ff0ae López-Jiménez, J. (Javier)|||/items/33646694-560a-48b0-a994-709826c7ff4d Spina, M. (Michelle)|||/items/45b7854c-ef1d-4f3c-a700-a29398e1363f Re, A. (Alessandro)|||/items/cc3b8cee-c417-4ff9-bd9b-58990744667f González de Villambrosía, S. (Sonia)|||/items/8b4e3aea-1e3d-4113-ab6c-f7d456e6130e Bobillo, S. (Sabella)|||/items/31e94435-1f28-46db-a819-dcdb5f89afb8 Federico, M. (Massimo)|||/items/33732a2a-f1df-4b5f-807c-b8e2e6c130c8 |
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| author_browse | Arranz, R. (Reyes)|||/items/497c50e1-0d74-4244-b0a9-fb8a6ec712a5 Bastos-Oreiro, M. (Mariana)|||/items/9798d413-d64d-4b19-b5cf-7987a1d80938 Bellei, M. (Monica)|||/items/066f8838-ec5c-4121-ad8f-2976d2f946a9 Bobillo, S. (Sabella)|||/items/31e94435-1f28-46db-a819-dcdb5f89afb8 Carrillo-Cruz, E. (Estrella)|||/items/e7430696-2680-4a72-905a-4e87a3322605 Cortés, M. (María)|||/items/f6b827b1-1288-4db3-b09c-e762bab4203d Dlouhy, I. (Ivan)|||/items/d63c50e5-0e8f-4129-8c3b-02c6f385905c Dodero, A. (Anna)|||/items/29078649-9179-4f2a-a305-9827711d4b27 Federico, M. (Massimo)|||/items/33732a2a-f1df-4b5f-807c-b8e2e6c130c8 Garcia-Torres, E. (Estefania)|||/items/db4f74a4-a769-415a-bc98-2fe0e0ae7ef8 González de Villambrosía, S. (Sonia)|||/items/8b4e3aea-1e3d-4113-ab6c-f7d456e6130e Gritti, G. (Giuseppe)|||/items/9978abb8-e9da-4b73-8705-3d5cec449ce9 Gutierrez, A. (Antonio)|||/items/cd08206a-1bde-4f25-a9e4-681014c712be Heras, N. (Natalia) de las|||/items/f8e78df7-bc72-404d-8122-60fc2976c701 Jarque, I. (Isidro)|||/items/1dc9f667-92fa-45b6-98dd-401c7ac878e3 Jiménez-Ubieto, A. (Ana)|||/items/9071b3c8-3ec5-4118-9204-38e17a52f4b5 Lopez-Parra, M. (Miriam)|||/items/5e1bb5db-95e6-4107-ab31-89287abeb248 López-Jiménez, J. (Javier)|||/items/33646694-560a-48b0-a994-709826c7ff4d Martín-García-Sancho, A. (Alejandro)|||/items/2740d7f3-f3f9-47e8-a162-1d3ae0b84548 Montalbán, C. (Carlos)|||/items/7c7c01be-65ba-416a-a29b-b05f212c1b27 Moraleda, J.M. (Jose Maria)|||/items/6a96c554-773d-428a-9003-41d37bb21477 Novelli, S. (Silvana)|||/items/5e682b30-3cca-4110-b8d0-f9a43770d9e4 Orsucci, L. (Lorella)|||/items/2d616949-b7b7-46f0-9692-646217b3477a Panizo, C. (Carlos)|||/items/a5fb9193-be12-418c-9a99-929473b7bb3b Pascual-Cascon, M.J. (Maria Jesus)|||/items/f0290602-545e-4756-b526-32b6d56ff0ae Petrucci, L. (Luigi)|||/items/2d1b869f-552b-4598-b07f-632a05466b75 Ramírez, M.J. (Maria José)|||/items/3c833d8f-d679-4602-828e-cd218813027a Re, A. (Alessandro)|||/items/cc3b8cee-c417-4ff9-bd9b-58990744667f Sancho, J. M. (Juan Manuel)|||/items/11e0ebcf-5625-4b2b-bd95-afd86d626bea Spina, M. (Michelle)|||/items/45b7854c-ef1d-4f3c-a700-a29398e1363f |
| author_facet | Martín-García-Sancho, A. (Alejandro)|||/items/2740d7f3-f3f9-47e8-a162-1d3ae0b84548 Bellei, M. (Monica)|||/items/066f8838-ec5c-4121-ad8f-2976d2f946a9 Lopez-Parra, M. (Miriam)|||/items/5e1bb5db-95e6-4107-ab31-89287abeb248 Gritti, G. (Giuseppe)|||/items/9978abb8-e9da-4b73-8705-3d5cec449ce9 Cortés, M. (María)|||/items/f6b827b1-1288-4db3-b09c-e762bab4203d Novelli, S. (Silvana)|||/items/5e682b30-3cca-4110-b8d0-f9a43770d9e4 Panizo, C. (Carlos)|||/items/a5fb9193-be12-418c-9a99-929473b7bb3b Petrucci, L. (Luigi)|||/items/2d1b869f-552b-4598-b07f-632a05466b75 Gutierrez, A. (Antonio)|||/items/cd08206a-1bde-4f25-a9e4-681014c712be Dlouhy, I. (Ivan)|||/items/d63c50e5-0e8f-4129-8c3b-02c6f385905c Bastos-Oreiro, M. (Mariana)|||/items/9798d413-d64d-4b19-b5cf-7987a1d80938 Sancho, J. M. (Juan Manuel)|||/items/11e0ebcf-5625-4b2b-bd95-afd86d626bea Ramírez, M.J. (Maria José)|||/items/3c833d8f-d679-4602-828e-cd218813027a Moraleda, J.M. (Jose Maria)|||/items/6a96c554-773d-428a-9003-41d37bb21477 Carrillo-Cruz, E. (Estrella)|||/items/e7430696-2680-4a72-905a-4e87a3322605 Jiménez-Ubieto, A. (Ana)|||/items/9071b3c8-3ec5-4118-9204-38e17a52f4b5 Jarque, I. (Isidro)|||/items/1dc9f667-92fa-45b6-98dd-401c7ac878e3 Orsucci, L. (Lorella)|||/items/2d616949-b7b7-46f0-9692-646217b3477a Garcia-Torres, E. (Estefania)|||/items/db4f74a4-a769-415a-bc98-2fe0e0ae7ef8 Montalbán, C. (Carlos)|||/items/7c7c01be-65ba-416a-a29b-b05f212c1b27 Dodero, A. (Anna)|||/items/29078649-9179-4f2a-a305-9827711d4b27 Arranz, R. (Reyes)|||/items/497c50e1-0d74-4244-b0a9-fb8a6ec712a5 Heras, N. (Natalia) de las|||/items/f8e78df7-bc72-404d-8122-60fc2976c701 Pascual-Cascon, M.J. (Maria Jesus)|||/items/f0290602-545e-4756-b526-32b6d56ff0ae López-Jiménez, J. (Javier)|||/items/33646694-560a-48b0-a994-709826c7ff4d Spina, M. (Michelle)|||/items/45b7854c-ef1d-4f3c-a700-a29398e1363f Re, A. (Alessandro)|||/items/cc3b8cee-c417-4ff9-bd9b-58990744667f González de Villambrosía, S. (Sonia)|||/items/8b4e3aea-1e3d-4113-ab6c-f7d456e6130e Bobillo, S. (Sabella)|||/items/31e94435-1f28-46db-a819-dcdb5f89afb8 Federico, M. (Massimo)|||/items/33732a2a-f1df-4b5f-807c-b8e2e6c130c8 |
| author_role | author |
| collection | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| description | Peripheral T-cell lymphomas (PTCL) are a heterogeneous group of rare lymphoid malignancies that mostly have poor prognoses with currently available treatments. Upfront consolidation with autologous stem cell transplantation (ASCT) is frequently carried out, but its efficacy has never been investigated in randomized trials. We designed a multicenter, international, retrospective study with the main objective of comparing progression-free survival and overall survival of patients with PTCL who underwent ASCT in complete remission (CR) after first-line chemotherapy with a control group who did not undergo ASCT. From the initial population of 286 registered patients, 174 patients with PTCL other than anaplastic large cell lymphoma, ALK-positive, deemed fit for ASCT at the time of diagnosis, and who were in CR or uncertain CR after induction therapy (CR1) were included in our analysis. one hundred and three patients underwent ASCT, whereas 71 did not, in most cases (n=53) because the physician decided against it. With a median follow-up of 65.5 months, progression-free survival was significantly better in the transplanted patients than in the non-transplanted group: 63% versus 48% at 5 years (P=0.042). Overall survival was significantly longer for ASCT patients in the subgroup with advanced stage at diagnosis (5-year overall survival: 70% vs. 50%, P=0.028). In the multivariate analysis, first-line ASCT was associated with significantly prolonged progression-free survival (HR=0.57, 95% CI: 0.35-0.93) and overall survival (HR=0.57, 95% CI: 0.33-0.99). In conclusion, our study supports the use of ASCT as a consolidation strategy for patients with PTCL in CR1. These results should be confirmed in a prospective randomized study. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_bacacb9a87d8a17c459dde8aadb4ee3b |
| institution | Universidad de Navarra |
| instname_str | Universidad de Navarra |
| language | eng |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:dnet:dadun_______::154565daf0ef4b4bb2d4dfc2a6329d6e |
| publishDate | 2022 |
| publishDateSort | 2022 |
| publisher | Ferrata Storti Foundation |
| publisherStr | Ferrata Storti Foundation |
| reponame_str | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| spelling | Autologous stem-cell transplantation as consolidation of first-line chemotherapy in patients with peripheral T-cell lymphoma: a multicenter GELTAMO/FIL study Martín-García-Sancho, A. (Alejandro)|||/items/2740d7f3-f3f9-47e8-a162-1d3ae0b84548 Bellei, M. (Monica)|||/items/066f8838-ec5c-4121-ad8f-2976d2f946a9 Lopez-Parra, M. (Miriam)|||/items/5e1bb5db-95e6-4107-ab31-89287abeb248 Gritti, G. (Giuseppe)|||/items/9978abb8-e9da-4b73-8705-3d5cec449ce9 Cortés, M. (María)|||/items/f6b827b1-1288-4db3-b09c-e762bab4203d Novelli, S. (Silvana)|||/items/5e682b30-3cca-4110-b8d0-f9a43770d9e4 Panizo, C. (Carlos)|||/items/a5fb9193-be12-418c-9a99-929473b7bb3b Petrucci, L. (Luigi)|||/items/2d1b869f-552b-4598-b07f-632a05466b75 Gutierrez, A. (Antonio)|||/items/cd08206a-1bde-4f25-a9e4-681014c712be Dlouhy, I. (Ivan)|||/items/d63c50e5-0e8f-4129-8c3b-02c6f385905c Bastos-Oreiro, M. (Mariana)|||/items/9798d413-d64d-4b19-b5cf-7987a1d80938 Sancho, J. M. (Juan Manuel)|||/items/11e0ebcf-5625-4b2b-bd95-afd86d626bea Ramírez, M.J. (Maria José)|||/items/3c833d8f-d679-4602-828e-cd218813027a Moraleda, J.M. (Jose Maria)|||/items/6a96c554-773d-428a-9003-41d37bb21477 Carrillo-Cruz, E. (Estrella)|||/items/e7430696-2680-4a72-905a-4e87a3322605 Jiménez-Ubieto, A. (Ana)|||/items/9071b3c8-3ec5-4118-9204-38e17a52f4b5 Jarque, I. (Isidro)|||/items/1dc9f667-92fa-45b6-98dd-401c7ac878e3 Orsucci, L. (Lorella)|||/items/2d616949-b7b7-46f0-9692-646217b3477a Garcia-Torres, E. (Estefania)|||/items/db4f74a4-a769-415a-bc98-2fe0e0ae7ef8 Montalbán, C. (Carlos)|||/items/7c7c01be-65ba-416a-a29b-b05f212c1b27 Dodero, A. (Anna)|||/items/29078649-9179-4f2a-a305-9827711d4b27 Arranz, R. (Reyes)|||/items/497c50e1-0d74-4244-b0a9-fb8a6ec712a5 Heras, N. (Natalia) de las|||/items/f8e78df7-bc72-404d-8122-60fc2976c701 Pascual-Cascon, M.J. (Maria Jesus)|||/items/f0290602-545e-4756-b526-32b6d56ff0ae López-Jiménez, J. (Javier)|||/items/33646694-560a-48b0-a994-709826c7ff4d Spina, M. (Michelle)|||/items/45b7854c-ef1d-4f3c-a700-a29398e1363f Re, A. (Alessandro)|||/items/cc3b8cee-c417-4ff9-bd9b-58990744667f González de Villambrosía, S. (Sonia)|||/items/8b4e3aea-1e3d-4113-ab6c-f7d456e6130e Bobillo, S. (Sabella)|||/items/31e94435-1f28-46db-a819-dcdb5f89afb8 Federico, M. (Massimo)|||/items/33732a2a-f1df-4b5f-807c-b8e2e6c130c8 Peripheral Lymphomas Autologous Transplantation Survival Peripheral T-cell lymphomas (PTCL) are a heterogeneous group of rare lymphoid malignancies that mostly have poor prognoses with currently available treatments. Upfront consolidation with autologous stem cell transplantation (ASCT) is frequently carried out, but its efficacy has never been investigated in randomized trials. We designed a multicenter, international, retrospective study with the main objective of comparing progression-free survival and overall survival of patients with PTCL who underwent ASCT in complete remission (CR) after first-line chemotherapy with a control group who did not undergo ASCT. From the initial population of 286 registered patients, 174 patients with PTCL other than anaplastic large cell lymphoma, ALK-positive, deemed fit for ASCT at the time of diagnosis, and who were in CR or uncertain CR after induction therapy (CR1) were included in our analysis. one hundred and three patients underwent ASCT, whereas 71 did not, in most cases (n=53) because the physician decided against it. With a median follow-up of 65.5 months, progression-free survival was significantly better in the transplanted patients than in the non-transplanted group: 63% versus 48% at 5 years (P=0.042). Overall survival was significantly longer for ASCT patients in the subgroup with advanced stage at diagnosis (5-year overall survival: 70% vs. 50%, P=0.028). In the multivariate analysis, first-line ASCT was associated with significantly prolonged progression-free survival (HR=0.57, 95% CI: 0.35-0.93) and overall survival (HR=0.57, 95% CI: 0.33-0.99). In conclusion, our study supports the use of ASCT as a consolidation strategy for patients with PTCL in CR1. These results should be confirmed in a prospective randomized study. Ferrata Storti Foundation https://hdl.handle.net/10171/124273 |
| spellingShingle | Autologous stem-cell transplantation as consolidation of first-line chemotherapy in patients with peripheral T-cell lymphoma: a multicenter GELTAMO/FIL study Martín-García-Sancho, A. (Alejandro)|||/items/2740d7f3-f3f9-47e8-a162-1d3ae0b84548 Peripheral Lymphomas Autologous Transplantation Survival |
| title | Autologous stem-cell transplantation as consolidation of first-line chemotherapy in patients with peripheral T-cell lymphoma: a multicenter GELTAMO/FIL study |
| title_full | Autologous stem-cell transplantation as consolidation of first-line chemotherapy in patients with peripheral T-cell lymphoma: a multicenter GELTAMO/FIL study |
| title_fullStr | Autologous stem-cell transplantation as consolidation of first-line chemotherapy in patients with peripheral T-cell lymphoma: a multicenter GELTAMO/FIL study |
| title_full_unstemmed | Autologous stem-cell transplantation as consolidation of first-line chemotherapy in patients with peripheral T-cell lymphoma: a multicenter GELTAMO/FIL study |
| title_short | Autologous stem-cell transplantation as consolidation of first-line chemotherapy in patients with peripheral T-cell lymphoma: a multicenter GELTAMO/FIL study |
| title_sort | Autologous stem-cell transplantation as consolidation of first-line chemotherapy in patients with peripheral T-cell lymphoma: a multicenter GELTAMO/FIL study |
| topic | Peripheral Lymphomas Autologous Transplantation Survival |
| topic_facet | Peripheral Lymphomas Autologous Transplantation Survival |
| url | https://hdl.handle.net/10171/124273 |