Circulating adrenomedullin in cirrhosis: relationship to hyperdynamic circulation
BACKGROUND/AIMS: Peripheral arterial vasodilation may be the key factor in the sodium and water retention of cirrhosis. The mechanism responsible for this vasodilation remains to be fully elucidated. Adrenomedullin is a novel peptide, highly expressed in cardiovascular tissues, with potent and long-...
| Authors: | ; ; ; ; ; ; ; ; |
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| Format: | Article |
| Publication date: | 1998 |
| Country: | España |
| Institution: | Universidad de Navarra |
| Repository: | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| Language: | English |
| OAI Identifier: | oai:dadun.unav.edu:10171/20164 |
| Online Access: | https://hdl.handle.net/10171/20164 |
| Access Level: | Open access |
| Keyword: | Adrenomedullin Cirrhosis Peripheral vasodilation |
| _version_ | 1878738973088546816 |
|---|---|
| author | Fernandez-Rodriguez, C.M. (Conrado M.)|||/items/e50a7eca-c5a3-4216-947d-0b819b03260e |
| author2 | Prada, I. (Ignacio R.)|||/items/054af025-bfbb-46ea-9db2-bd60352532b6 Prieto, J. (Jesús)|||/items/0d9c3dec-4a09-400d-8c83-23ece1096c71 Montuenga-Badia, L.M. (Luis M.)|||/items/4c999705-b2c9-45ac-ba13-3f18594ae596 Elssasser, T. (T.)|||/items/84168d37-2bdf-4115-a6ee-c49a74533593 Quiroga, J. (Jorge)|||/items/580a0a4e-16a6-446c-840c-3e225592fa4b Moreiras, M. (Mercedes)|||/items/3196b00f-3756-4259-bd94-2be9e4c4a058 Andrade, A. (Amalia)|||/items/aa8b166a-acd9-464d-97b1-dcdbd3af5ddd Cuttitta, F. (Frank)|||/items/0f0da08c-0efe-4d3c-97ca-44c38a26e188 |
| author2_role | author author author author author author author author |
| author_browse | Andrade, A. (Amalia)|||/items/aa8b166a-acd9-464d-97b1-dcdbd3af5ddd Cuttitta, F. (Frank)|||/items/0f0da08c-0efe-4d3c-97ca-44c38a26e188 Elssasser, T. (T.)|||/items/84168d37-2bdf-4115-a6ee-c49a74533593 Fernandez-Rodriguez, C.M. (Conrado M.)|||/items/e50a7eca-c5a3-4216-947d-0b819b03260e Montuenga-Badia, L.M. (Luis M.)|||/items/4c999705-b2c9-45ac-ba13-3f18594ae596 Moreiras, M. (Mercedes)|||/items/3196b00f-3756-4259-bd94-2be9e4c4a058 Prada, I. (Ignacio R.)|||/items/054af025-bfbb-46ea-9db2-bd60352532b6 Prieto, J. (Jesús)|||/items/0d9c3dec-4a09-400d-8c83-23ece1096c71 Quiroga, J. (Jorge)|||/items/580a0a4e-16a6-446c-840c-3e225592fa4b |
| author_facet | Fernandez-Rodriguez, C.M. (Conrado M.)|||/items/e50a7eca-c5a3-4216-947d-0b819b03260e Prada, I. (Ignacio R.)|||/items/054af025-bfbb-46ea-9db2-bd60352532b6 Prieto, J. (Jesús)|||/items/0d9c3dec-4a09-400d-8c83-23ece1096c71 Montuenga-Badia, L.M. (Luis M.)|||/items/4c999705-b2c9-45ac-ba13-3f18594ae596 Elssasser, T. (T.)|||/items/84168d37-2bdf-4115-a6ee-c49a74533593 Quiroga, J. (Jorge)|||/items/580a0a4e-16a6-446c-840c-3e225592fa4b Moreiras, M. (Mercedes)|||/items/3196b00f-3756-4259-bd94-2be9e4c4a058 Andrade, A. (Amalia)|||/items/aa8b166a-acd9-464d-97b1-dcdbd3af5ddd Cuttitta, F. (Frank)|||/items/0f0da08c-0efe-4d3c-97ca-44c38a26e188 |
| author_role | author |
| collection | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| description | BACKGROUND/AIMS: Peripheral arterial vasodilation may be the key factor in the sodium and water retention of cirrhosis. The mechanism responsible for this vasodilation remains to be fully elucidated. Adrenomedullin is a novel peptide, highly expressed in cardiovascular tissues, with potent and long-lasting vasodilating activity. METHODS: The possible implication of adrenomedullin in the hemodynamic changes of cirrhosis has been investigated. We measured the plasma concentration of adrenomedullin in 20 cirrhotic patients and 11 healthy subjects. In addition, systemic, portal and renal hemodynamics, hormonal factors and renal function parameters were evaluated in the same patients. RESULTS: Circulating adrenomedullin was significantly higher in the group of patients with cirrhosis (72.1; 46-100 vs 21.6; 11-34 fmol/dl, respectively; p<0.02) and was directly correlated with the Pugh score (r: 0.6; p: 0.01), inversely correlated with the creatinine clearance (r: -0.6; p<0.01) and tended to inversely correlate with systemic vascular resistance index (r: -0.46; p: 0.07). There were no portal-peripheral differences in adrenomedullin levels. Transjugular intrahepatic portosystemic shunt insertion did not induce changes in the peripheral concentration of adrenomedullin, but baseline values of this hormone predicted the degree of hyperdynamic circulation after TIPS. CONCLUSIONS: Circulating adrenomedullin is increased in cirrhosis. These levels increase with the severity of the disease, especially in patients with hepatorenal syndrome. This peptide may contribute to vasodilation of cirrhosis. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_b8aa5fc3e47d53cce0da8f2fa266fa0e |
| institution | Universidad de Navarra |
| instname_str | Universidad de Navarra |
| language | eng |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:dadun.unav.edu:10171/20164 |
| publishDate | 1998 |
| publishDateSort | 1998 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| reponame_str | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| spelling | Circulating adrenomedullin in cirrhosis: relationship to hyperdynamic circulation Fernandez-Rodriguez, C.M. (Conrado M.)|||/items/e50a7eca-c5a3-4216-947d-0b819b03260e Prada, I. (Ignacio R.)|||/items/054af025-bfbb-46ea-9db2-bd60352532b6 Prieto, J. (Jesús)|||/items/0d9c3dec-4a09-400d-8c83-23ece1096c71 Montuenga-Badia, L.M. (Luis M.)|||/items/4c999705-b2c9-45ac-ba13-3f18594ae596 Elssasser, T. (T.)|||/items/84168d37-2bdf-4115-a6ee-c49a74533593 Quiroga, J. (Jorge)|||/items/580a0a4e-16a6-446c-840c-3e225592fa4b Moreiras, M. (Mercedes)|||/items/3196b00f-3756-4259-bd94-2be9e4c4a058 Andrade, A. (Amalia)|||/items/aa8b166a-acd9-464d-97b1-dcdbd3af5ddd Cuttitta, F. (Frank)|||/items/0f0da08c-0efe-4d3c-97ca-44c38a26e188 Adrenomedullin Cirrhosis Peripheral vasodilation BACKGROUND/AIMS: Peripheral arterial vasodilation may be the key factor in the sodium and water retention of cirrhosis. The mechanism responsible for this vasodilation remains to be fully elucidated. Adrenomedullin is a novel peptide, highly expressed in cardiovascular tissues, with potent and long-lasting vasodilating activity. METHODS: The possible implication of adrenomedullin in the hemodynamic changes of cirrhosis has been investigated. We measured the plasma concentration of adrenomedullin in 20 cirrhotic patients and 11 healthy subjects. In addition, systemic, portal and renal hemodynamics, hormonal factors and renal function parameters were evaluated in the same patients. RESULTS: Circulating adrenomedullin was significantly higher in the group of patients with cirrhosis (72.1; 46-100 vs 21.6; 11-34 fmol/dl, respectively; p<0.02) and was directly correlated with the Pugh score (r: 0.6; p: 0.01), inversely correlated with the creatinine clearance (r: -0.6; p<0.01) and tended to inversely correlate with systemic vascular resistance index (r: -0.46; p: 0.07). There were no portal-peripheral differences in adrenomedullin levels. Transjugular intrahepatic portosystemic shunt insertion did not induce changes in the peripheral concentration of adrenomedullin, but baseline values of this hormone predicted the degree of hyperdynamic circulation after TIPS. CONCLUSIONS: Circulating adrenomedullin is increased in cirrhosis. These levels increase with the severity of the disease, especially in patients with hepatorenal syndrome. This peptide may contribute to vasodilation of cirrhosis. Elsevier https://hdl.handle.net/10171/20164 |
| spellingShingle | Circulating adrenomedullin in cirrhosis: relationship to hyperdynamic circulation Fernandez-Rodriguez, C.M. (Conrado M.)|||/items/e50a7eca-c5a3-4216-947d-0b819b03260e Adrenomedullin Cirrhosis Peripheral vasodilation |
| title | Circulating adrenomedullin in cirrhosis: relationship to hyperdynamic circulation |
| title_full | Circulating adrenomedullin in cirrhosis: relationship to hyperdynamic circulation |
| title_fullStr | Circulating adrenomedullin in cirrhosis: relationship to hyperdynamic circulation |
| title_full_unstemmed | Circulating adrenomedullin in cirrhosis: relationship to hyperdynamic circulation |
| title_short | Circulating adrenomedullin in cirrhosis: relationship to hyperdynamic circulation |
| title_sort | Circulating adrenomedullin in cirrhosis: relationship to hyperdynamic circulation |
| topic | Adrenomedullin Cirrhosis Peripheral vasodilation |
| topic_facet | Adrenomedullin Cirrhosis Peripheral vasodilation |
| url | https://hdl.handle.net/10171/20164 |