Comparison of Endogenous Alpharetroviruses (ALV-like) across Galliform Species: New Distant Proviruses
The Genus Alpharetrovirus contains viruses pathogenic mainly for chickens, forming the Avian Sarcoma and Leukosis Virus group (ASLV). Cells of most Galliform species, besides chickens, contain genetic elements (endogenous retroviruses, ERVs) that could recombine with other alpharetroviruses or expre...
| Autores: | ; ; ; |
|---|---|
| Tipo de documento: | Artículo |
| Fecha de publicación: | 2023 |
| País: | España |
| Institución: | Universidad Complutense de Madrid (UCM) |
| Repositorio: | Docta Complutense |
| Lenguaje: | Inglés |
| OAI Identifier: | oai:docta.ucm.es:20.500.14352/103389 |
| Acceso en línea: | https://hdl.handle.net/20.500.14352/103389 |
| Nivel de acceso: | Acceso abierto |
| Palabra clave: | 578.8 598.2 636.5 Galliformes phylogenetics Alpharetrovirus Avian Leukosis Virus (ALV) Endogenous viruses Phylogenetics ERVs Aves Microbiología (Biología) 3109.05 Microbiología 2401.20 Ornitología |
| _version_ | 1878738972798091264 |
|---|---|
| author | Fandiño, Sergio |
| author2 | Gómez-Lucía Duato, María Esperanza Benítez Rico, Laura Domenech Gómez, Ana María |
| author2_role | author author author |
| author_browse | Benítez Rico, Laura Domenech Gómez, Ana María Fandiño, Sergio Gómez-Lucía Duato, María Esperanza |
| author_facet | Fandiño, Sergio Gómez-Lucía Duato, María Esperanza Benítez Rico, Laura Domenech Gómez, Ana María |
| author_role | author |
| collection | Docta Complutense |
| description | The Genus Alpharetrovirus contains viruses pathogenic mainly for chickens, forming the Avian Sarcoma and Leukosis Virus group (ASLV). Cells of most Galliform species, besides chickens, contain genetic elements (endogenous retroviruses, ERVs) that could recombine with other alpharetroviruses or express proteins, complementing defective ASLV, which may successfully replicate and cause disease. However, they are quite unknown, and only ALV-F, from ring-necked pheasants, has been partially published. Upon scrutiny of 53 genomes of different avian species, we found Alpharetrovirus-like sequences only in 12 different Galliformes, including six full-length (7.4–7.6 Kbp) and 27 partial sequences. Phylogenetic studies of the regions studied (LTR, gag, pol, and env) consistently resulted in five almost identical clades containing the same ERVs: Clade I (presently known ASLVs); Clade II (Callipepla spp. ERVs); Clade IIIa (Phasianus colchicus ERVs); Clade IIIb (Alectoris spp. ERVs); and Clade IV (Centrocercus spp. ERVs). The low pol identity scores suggested that each of these Clades may be considered a different species. ORF analysis revealed that putatively encoded proteins would be very similar in length and domains to those of other alpharetroviruses and thus potentially functional. This will undoubtedly contribute to better understanding the biology of defective viruses, especially in wild Galliformes, their evolution, and the danger they may represent for other wild species and the poultry industry. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_b8a47fad2bbfa45e60cfa4915d96d57a |
| institution | Universidad Complutense de Madrid (UCM) |
| instname_str | Universidad Complutense de Madrid (UCM) |
| language | eng |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:docta.ucm.es:20.500.14352/103389 |
| publishDate | 2023 |
| publishDateSort | 2023 |
| publisher | MDPI |
| publisherStr | MDPI |
| reponame_str | Docta Complutense |
| spelling | Comparison of Endogenous Alpharetroviruses (ALV-like) across Galliform Species: New Distant Proviruses Fandiño, Sergio Gómez-Lucía Duato, María Esperanza Benítez Rico, Laura Domenech Gómez, Ana María 578.8 598.2 636.5 Galliformes phylogenetics Alpharetrovirus Avian Leukosis Virus (ALV) Endogenous viruses Phylogenetics ERVs Aves Microbiología (Biología) 3109.05 Microbiología 2401.20 Ornitología The Genus Alpharetrovirus contains viruses pathogenic mainly for chickens, forming the Avian Sarcoma and Leukosis Virus group (ASLV). Cells of most Galliform species, besides chickens, contain genetic elements (endogenous retroviruses, ERVs) that could recombine with other alpharetroviruses or express proteins, complementing defective ASLV, which may successfully replicate and cause disease. However, they are quite unknown, and only ALV-F, from ring-necked pheasants, has been partially published. Upon scrutiny of 53 genomes of different avian species, we found Alpharetrovirus-like sequences only in 12 different Galliformes, including six full-length (7.4–7.6 Kbp) and 27 partial sequences. Phylogenetic studies of the regions studied (LTR, gag, pol, and env) consistently resulted in five almost identical clades containing the same ERVs: Clade I (presently known ASLVs); Clade II (Callipepla spp. ERVs); Clade IIIa (Phasianus colchicus ERVs); Clade IIIb (Alectoris spp. ERVs); and Clade IV (Centrocercus spp. ERVs). The low pol identity scores suggested that each of these Clades may be considered a different species. ORF analysis revealed that putatively encoded proteins would be very similar in length and domains to those of other alpharetroviruses and thus potentially functional. This will undoubtedly contribute to better understanding the biology of defective viruses, especially in wild Galliformes, their evolution, and the danger they may represent for other wild species and the poultry industry. MDPI https://hdl.handle.net/20.500.14352/103389 |
| spellingShingle | Comparison of Endogenous Alpharetroviruses (ALV-like) across Galliform Species: New Distant Proviruses Fandiño, Sergio 578.8 598.2 636.5 Galliformes phylogenetics Alpharetrovirus Avian Leukosis Virus (ALV) Endogenous viruses Phylogenetics ERVs Aves Microbiología (Biología) 3109.05 Microbiología 2401.20 Ornitología |
| title | Comparison of Endogenous Alpharetroviruses (ALV-like) across Galliform Species: New Distant Proviruses |
| title_full | Comparison of Endogenous Alpharetroviruses (ALV-like) across Galliform Species: New Distant Proviruses |
| title_fullStr | Comparison of Endogenous Alpharetroviruses (ALV-like) across Galliform Species: New Distant Proviruses |
| title_full_unstemmed | Comparison of Endogenous Alpharetroviruses (ALV-like) across Galliform Species: New Distant Proviruses |
| title_short | Comparison of Endogenous Alpharetroviruses (ALV-like) across Galliform Species: New Distant Proviruses |
| title_sort | Comparison of Endogenous Alpharetroviruses (ALV-like) across Galliform Species: New Distant Proviruses |
| topic | 578.8 598.2 636.5 Galliformes phylogenetics Alpharetrovirus Avian Leukosis Virus (ALV) Endogenous viruses Phylogenetics ERVs Aves Microbiología (Biología) 3109.05 Microbiología 2401.20 Ornitología |
| topic_facet | 578.8 598.2 636.5 Galliformes phylogenetics Alpharetrovirus Avian Leukosis Virus (ALV) Endogenous viruses Phylogenetics ERVs Aves Microbiología (Biología) 3109.05 Microbiología 2401.20 Ornitología |
| url | https://hdl.handle.net/20.500.14352/103389 |