Sulfonylurea Receptor 1 in Central Nervous System Injury: An Updated Review
Hinchazón celular; Edema; Traumatismo cerebral
| Authors: | ; ; ; ; ; ; |
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| Format: | Article |
| Status: | Published version |
| Publication date: | 2021 |
| Country: | España |
| Institution: | Departament de Salut de la Generalitat de Catalunya (DS) |
| Repository: | Scientia. Dipòsit d'Informació Digital del Departament de Salut |
| OAI Identifier: | oai:scientiasalut.gencat.cat:11351/7522 |
| Online Access: | https://hdl.handle.net/11351/7522 |
| Access Level: | Open access |
| Keyword: | Sistema nerviós central - Malalties Canals de potassi - Metabolisme DISEASES::Nervous System Diseases::Central Nervous System Diseases CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::Carrier Proteins::Membrane Transport Proteins::Ion Channels::Potassium Channels::Potassium Channels, Inwardly Rectifying::KATP Channels::Sulfonylurea Receptors Other subheadings::Other subheadings::Other subheadings::/metabolism ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::proteínas transportadoras::proteínas de transporte de membrana::canales iónicos::canales del potasio::canales del potasio de correción hacia el interior::canales KATP::receptores de sulfonilureas Otros calificadores::Otros calificadores::Otros calificadores::/metabolismo |
| _version_ | 1878738778793705472 |
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| author | Jha, Ruchira M. |
| author2 | Rani, Anupama Desai, Shashvat M. Raikwar, Sudhanshu Mihaljevic, Sandra Munoz Casabella, Amanda Sahuquillo Barris, Joan |
| author2_role | author author author author author author |
| author_browse | Desai, Shashvat M. Jha, Ruchira M. Mihaljevic, Sandra Munoz Casabella, Amanda Raikwar, Sudhanshu Rani, Anupama Sahuquillo Barris, Joan |
| author_facet | Jha, Ruchira M. Rani, Anupama Desai, Shashvat M. Raikwar, Sudhanshu Mihaljevic, Sandra Munoz Casabella, Amanda Sahuquillo Barris, Joan |
| author_role | author |
| collection | Scientia. Dipòsit d'Informació Digital del Departament de Salut |
| description | Hinchazón celular; Edema; Traumatismo cerebral |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_b4ff66ddd5b4fdaf42ce4e9f76e617b2 |
| institution | Departament de Salut de la Generalitat de Catalunya (DS) |
| instname_str | Departament de Salut de la Generalitat de Catalunya (DS) |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:scientiasalut.gencat.cat:11351/7522 |
| publishDate | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI |
| publisherStr | MDPI |
| reponame_str | Scientia. Dipòsit d'Informació Digital del Departament de Salut |
| spelling | Sulfonylurea Receptor 1 in Central Nervous System Injury: An Updated Review Jha, Ruchira M. Rani, Anupama Desai, Shashvat M. Raikwar, Sudhanshu Mihaljevic, Sandra Munoz Casabella, Amanda Sahuquillo Barris, Joan Sistema nerviós central - Malalties Canals de potassi - Metabolisme DISEASES::Nervous System Diseases::Central Nervous System Diseases CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::Carrier Proteins::Membrane Transport Proteins::Ion Channels::Potassium Channels::Potassium Channels, Inwardly Rectifying::KATP Channels::Sulfonylurea Receptors Other subheadings::Other subheadings::Other subheadings::/metabolism ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::proteínas transportadoras::proteínas de transporte de membrana::canales iónicos::canales del potasio::canales del potasio de correción hacia el interior::canales KATP::receptores de sulfonilureas Otros calificadores::Otros calificadores::Otros calificadores::/metabolismo Hinchazón celular; Edema; Traumatismo cerebral Cellular swelling; Edema; Traumatic brain injury Inflor cel·lular; Edema; Traumatisme cerebral Sulfonylurea receptor 1 (SUR1) is a member of the adenosine triphosphate (ATP)-binding cassette (ABC) protein superfamily, encoded by Abcc8, and is recognized as a key mediator of central nervous system (CNS) cellular swelling via the transient receptor potential melastatin 4 (TRPM4) channel. Discovered approximately 20 years ago, this channel is normally absent in the CNS but is transcriptionally upregulated after CNS injury. A comprehensive review on the pathophysiology and role of SUR1 in the CNS was published in 2012. Since then, the breadth and depth of understanding of the involvement of this channel in secondary injury has undergone exponential growth: SUR1-TRPM4 inhibition has been shown to decrease cerebral edema and hemorrhage progression in multiple preclinical models as well as in early clinical studies across a range of CNS diseases including ischemic stroke, traumatic brain injury, cardiac arrest, subarachnoid hemorrhage, spinal cord injury, intracerebral hemorrhage, multiple sclerosis, encephalitis, neuromalignancies, pain, liver failure, status epilepticus, retinopathies and HIV-associated neurocognitive disorder. Given these substantial developments, combined with the timeliness of ongoing clinical trials of SUR1 inhibition, now, another decade later, we review advances pertaining to SUR1-TRPM4 pathobiology in this spectrum of CNS disease—providing an overview of the journey from patch-clamp experiments to phase III trials. No funding directly supported the writing of this review. R.M.J. is supported by grants from the National Institute of Neurological Disorders and Stroke (NINDS) (K23NS101036; R01NS115815), and the Barrow Neurological Foundation. J.M.S. is supported by grants from the Department of Veterans Affairs (I01RX003060; 1I01BX004652), the Department of Defense (SC170199), the National Heart, Lung and Blood Institute (R01HL082517) and the NINDS (R01NS102589; R01NS105633). MDPI https://hdl.handle.net/11351/7522 |
| spellingShingle | Sulfonylurea Receptor 1 in Central Nervous System Injury: An Updated Review Jha, Ruchira M. Sistema nerviós central - Malalties Canals de potassi - Metabolisme DISEASES::Nervous System Diseases::Central Nervous System Diseases CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::Carrier Proteins::Membrane Transport Proteins::Ion Channels::Potassium Channels::Potassium Channels, Inwardly Rectifying::KATP Channels::Sulfonylurea Receptors Other subheadings::Other subheadings::Other subheadings::/metabolism ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::proteínas transportadoras::proteínas de transporte de membrana::canales iónicos::canales del potasio::canales del potasio de correción hacia el interior::canales KATP::receptores de sulfonilureas Otros calificadores::Otros calificadores::Otros calificadores::/metabolismo |
| status_str | publishedVersion |
| title | Sulfonylurea Receptor 1 in Central Nervous System Injury: An Updated Review |
| title_full | Sulfonylurea Receptor 1 in Central Nervous System Injury: An Updated Review |
| title_fullStr | Sulfonylurea Receptor 1 in Central Nervous System Injury: An Updated Review |
| title_full_unstemmed | Sulfonylurea Receptor 1 in Central Nervous System Injury: An Updated Review |
| title_short | Sulfonylurea Receptor 1 in Central Nervous System Injury: An Updated Review |
| title_sort | Sulfonylurea Receptor 1 in Central Nervous System Injury: An Updated Review |
| topic | Sistema nerviós central - Malalties Canals de potassi - Metabolisme DISEASES::Nervous System Diseases::Central Nervous System Diseases CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::Carrier Proteins::Membrane Transport Proteins::Ion Channels::Potassium Channels::Potassium Channels, Inwardly Rectifying::KATP Channels::Sulfonylurea Receptors Other subheadings::Other subheadings::Other subheadings::/metabolism ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::proteínas transportadoras::proteínas de transporte de membrana::canales iónicos::canales del potasio::canales del potasio de correción hacia el interior::canales KATP::receptores de sulfonilureas Otros calificadores::Otros calificadores::Otros calificadores::/metabolismo |
| topic_facet | Sistema nerviós central - Malalties Canals de potassi - Metabolisme DISEASES::Nervous System Diseases::Central Nervous System Diseases CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::Carrier Proteins::Membrane Transport Proteins::Ion Channels::Potassium Channels::Potassium Channels, Inwardly Rectifying::KATP Channels::Sulfonylurea Receptors Other subheadings::Other subheadings::Other subheadings::/metabolism ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::proteínas transportadoras::proteínas de transporte de membrana::canales iónicos::canales del potasio::canales del potasio de correción hacia el interior::canales KATP::receptores de sulfonilureas Otros calificadores::Otros calificadores::Otros calificadores::/metabolismo |
| url | https://hdl.handle.net/11351/7522 |