Plant Protease Inhibitors as Emerging Antimicrobial Peptide Agents
Antimicrobial peptides (AMPs) are important mediator molecules of the innate defense mechanisms in a wide range of living organisms, including bacteria, mammals, and plants. Among them, peptide protease inhibitors (PPIs) from plants play a central role in their defense mechanisms by directly attacki...
| Authors: | ; ; ; ; |
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| Format: | Article |
| Publication date: | 2024 |
| Country: | España |
| Institution: | Universitat Autònoma de Barcelona |
| Repository: | Dipòsit Digital de Documents de la UAB |
| Language: | English |
| OAI Identifier: | oai:ddd.uab.cat:293864 |
| Online Access: | https://ddd.uab.cat/record/293864 https://dx.doi.org/urn:doi:10.3390/pharmaceutics16050582 |
| Access Level: | Open access |
| Keyword: | Plant protease inhibitors Antibacterial compounds Antimicrobial activity Antimicrobial peptides Antibiotic resistance Antifungal agents Cysteine-rich peptides |
| _version_ | 1878738694669598720 |
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| author | Parisi, Mónica G.|||0000-0002-6167-1436 |
| author2 | Ozón, Brenda|||0009-0003-6368-3742 Vera González, Sofía M.|||0009-0009-8317-4930 Garcia-Pardo, Javier|||0000-0001-9179-6371 Obregón, Walter David |
| author2_role | author author author author |
| author_browse | Garcia-Pardo, Javier|||0000-0001-9179-6371 Obregón, Walter David Ozón, Brenda|||0009-0003-6368-3742 Parisi, Mónica G.|||0000-0002-6167-1436 Vera González, Sofía M.|||0009-0009-8317-4930 |
| author_facet | Parisi, Mónica G.|||0000-0002-6167-1436 Ozón, Brenda|||0009-0003-6368-3742 Vera González, Sofía M.|||0009-0009-8317-4930 Garcia-Pardo, Javier|||0000-0001-9179-6371 Obregón, Walter David |
| author_role | author |
| collection | Dipòsit Digital de Documents de la UAB |
| description | Antimicrobial peptides (AMPs) are important mediator molecules of the innate defense mechanisms in a wide range of living organisms, including bacteria, mammals, and plants. Among them, peptide protease inhibitors (PPIs) from plants play a central role in their defense mechanisms by directly attacking pathogens or by modulating the plant's defense response. The growing prevalence of microbial resistance to currently available antibiotics has intensified the interest concerning these molecules as novel antimicrobial agents. In this scenario, PPIs isolated from a variety of plants have shown potential in inhibiting the growth of pathogenic bacteria, protozoans, and fungal strains, either by interfering with essential biochemical or physiological processes or by altering the permeability of biological membranes of invading organisms. Moreover, these molecules are active inhibitors of a range of proteases, including aspartic, serine, and cysteine types, with some showing particular efficacy as trypsin and chymotrypsin inhibitors. In this review, we provide a comprehensive analysis of the potential of plant-derived PPIs as novel antimicrobial molecules, highlighting their broad-spectrum antimicrobial efficacy, specificity, and minimal toxicity. These natural compounds exhibit diverse mechanisms of action and often multifunctionality, positioning them as promising molecular scaffolds for developing new therapeutic antibacterial agents. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_b367e9ca842ef1bb70a5aac514b673f7 |
| institution | Universitat Autònoma de Barcelona |
| instname_str | Universitat Autònoma de Barcelona |
| language | eng |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:ddd.uab.cat:293864 |
| publishDate | 2024 |
| publishDateSort | 2024 |
| reponame_str | Dipòsit Digital de Documents de la UAB |
| spelling | Plant Protease Inhibitors as Emerging Antimicrobial Peptide Agents A Comprehensive Review Parisi, Mónica G.|||0000-0002-6167-1436 Ozón, Brenda|||0009-0003-6368-3742 Vera González, Sofía M.|||0009-0009-8317-4930 Garcia-Pardo, Javier|||0000-0001-9179-6371 Obregón, Walter David Plant protease inhibitors Antibacterial compounds Antimicrobial activity Antimicrobial peptides Antibiotic resistance Antifungal agents Cysteine-rich peptides Antimicrobial peptides (AMPs) are important mediator molecules of the innate defense mechanisms in a wide range of living organisms, including bacteria, mammals, and plants. Among them, peptide protease inhibitors (PPIs) from plants play a central role in their defense mechanisms by directly attacking pathogens or by modulating the plant's defense response. The growing prevalence of microbial resistance to currently available antibiotics has intensified the interest concerning these molecules as novel antimicrobial agents. In this scenario, PPIs isolated from a variety of plants have shown potential in inhibiting the growth of pathogenic bacteria, protozoans, and fungal strains, either by interfering with essential biochemical or physiological processes or by altering the permeability of biological membranes of invading organisms. Moreover, these molecules are active inhibitors of a range of proteases, including aspartic, serine, and cysteine types, with some showing particular efficacy as trypsin and chymotrypsin inhibitors. In this review, we provide a comprehensive analysis of the potential of plant-derived PPIs as novel antimicrobial molecules, highlighting their broad-spectrum antimicrobial efficacy, specificity, and minimal toxicity. These natural compounds exhibit diverse mechanisms of action and often multifunctionality, positioning them as promising molecular scaffolds for developing new therapeutic antibacterial agents. https://ddd.uab.cat/record/293864 https://dx.doi.org/urn:doi:10.3390/pharmaceutics16050582 |
| spellingShingle | Plant Protease Inhibitors as Emerging Antimicrobial Peptide Agents Parisi, Mónica G.|||0000-0002-6167-1436 Plant protease inhibitors Antibacterial compounds Antimicrobial activity Antimicrobial peptides Antibiotic resistance Antifungal agents Cysteine-rich peptides |
| title | Plant Protease Inhibitors as Emerging Antimicrobial Peptide Agents |
| title_full | Plant Protease Inhibitors as Emerging Antimicrobial Peptide Agents |
| title_fullStr | Plant Protease Inhibitors as Emerging Antimicrobial Peptide Agents |
| title_full_unstemmed | Plant Protease Inhibitors as Emerging Antimicrobial Peptide Agents |
| title_short | Plant Protease Inhibitors as Emerging Antimicrobial Peptide Agents |
| title_sort | Plant Protease Inhibitors as Emerging Antimicrobial Peptide Agents |
| topic | Plant protease inhibitors Antibacterial compounds Antimicrobial activity Antimicrobial peptides Antibiotic resistance Antifungal agents Cysteine-rich peptides |
| topic_facet | Plant protease inhibitors Antibacterial compounds Antimicrobial activity Antimicrobial peptides Antibiotic resistance Antifungal agents Cysteine-rich peptides |
| url | https://ddd.uab.cat/record/293864 https://dx.doi.org/urn:doi:10.3390/pharmaceutics16050582 |