Meningococcal serogroups and surveillance: a systematic review and survey
Background: Meningococcal disease continues to be a global public health concern due to its epidemic potential, severity, and sequelae. The global epidemiological data on circulating meningococcal serogroups have never been reviewed concurrently with the laboratory capacity for meningococcal surveil...
| Authors: | ; ; ; ; ; ; ; ; ; ; ; ; ; |
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| Format: | Article |
| Publication date: | 2019 |
| Country: | España |
| Institution: | Instituto de Salud Carlos III (ISCIII) |
| Repository: | Repisalud |
| Language: | English |
| OAI Identifier: | oai:repisalud.isciii.es:20.500.12105/7530 |
| Online Access: | http://hdl.handle.net/20.500.12105/7530 |
| Access Level: | Open access |
| Keyword: | Global Health Humans Meningococcal Infections Meningococcal Vaccines Neisseria meningitidis Serogroup |
| _version_ | 1878738479528017920 |
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| author | Peterson, Meagan E |
| author2 | Li, You Bita, André Moureau, Annick Nair, Harish Kyaw, Moe H Abad, Raquel Bailey, Freddie de la Fuente Garcia, Isabel Decheva, Antoaneta Krizova, Pavla Melillo, Tanya Skoczyńska, Anna Vladimirova, Nadezhda |
| author2_role | author author author author author author author author author author author author author |
| author_browse | Abad, Raquel Bailey, Freddie Bita, André Decheva, Antoaneta Krizova, Pavla Kyaw, Moe H Li, You Melillo, Tanya Moureau, Annick Nair, Harish Peterson, Meagan E Skoczyńska, Anna Vladimirova, Nadezhda de la Fuente Garcia, Isabel |
| author_facet | Peterson, Meagan E Li, You Bita, André Moureau, Annick Nair, Harish Kyaw, Moe H Abad, Raquel Bailey, Freddie de la Fuente Garcia, Isabel Decheva, Antoaneta Krizova, Pavla Melillo, Tanya Skoczyńska, Anna Vladimirova, Nadezhda |
| author_role | author |
| collection | Repisalud |
| description | Background: Meningococcal disease continues to be a global public health concern due to its epidemic potential, severity, and sequelae. The global epidemiological data on circulating meningococcal serogroups have never been reviewed concurrently with the laboratory capacity for meningococcal surveillance at the national level. We, therefore, aimed to conduct a country-level review of meningococcal surveillance, serogroup distribution, and vaccine use. Methods: We conducted a systematic literature review across six databases to identify studies (published January 1, 2010 to October 16, 2017) and grey literature reporting meningococcal serogroup data for the years 2010-2016. We performed independent random effects meta-analyses for serogroups A, B, C, W, X, Y, and other. We developed and circulated a questionnaire-based survey to surveillance focal points in countries (N = 95) with known regional bacterial meningitis surveillance programs to assess their surveillance capacity and summarized using descriptive methods. Results: We included 173 studies from 59 countries in the final analysis. The distribution of meningococcal serogroups differed markedly between countries and regions. Meningococcal serogroups C and W accounted for substantial proportions of meningococcal disease in most of Africa and Latin America. Serogroup B was the predominant cause of meningococcal disease in many locations in Europe, the Americas, and the Western Pacific. Serogroup Y also caused many cases of meningococcal disease in these regions, particularly in Nordic countries. Survey responses were received from 51 countries. All countries reported the ability to confirm the pathogen in-country, while approximately 30% either relied on reference laboratories for serogrouping (N = 10) or did not serogroup specimens (N = 5). Approximately half of countries did not utilize active laboratory-based surveillance system (N = 22). Nationwide use of a meningococcal vaccine varied, but most countries (N = 36) utilized a meningococcal vaccine at least for certain high-risk population groups, in private care, or during outbreaks. Conclusions: Due to the large geographical variations in circulating meningococcal serogroups, each country should continue to be monitored for changes in major disease-causing serogroups in order to inform vaccine and control policies. Similarly, laboratory capacity should be appropriately scaled up to more accurately understand local epidemiology and disease burden, as well as the impact of vaccination programs. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_afb02a80972cfaf9a2f8d4b08ae2b5ce |
| institution | Instituto de Salud Carlos III (ISCIII) |
| instname_str | Instituto de Salud Carlos III (ISCIII) |
| language | eng |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:repisalud.isciii.es:20.500.12105/7530 |
| publishDate | 2019 |
| publishDateSort | 2019 |
| publisher | Edinburgh University Press |
| publisherStr | Edinburgh University Press |
| reponame_str | Repisalud |
| spelling | Meningococcal serogroups and surveillance: a systematic review and survey Peterson, Meagan E Li, You Bita, André Moureau, Annick Nair, Harish Kyaw, Moe H Abad, Raquel Bailey, Freddie de la Fuente Garcia, Isabel Decheva, Antoaneta Krizova, Pavla Melillo, Tanya Skoczyńska, Anna Vladimirova, Nadezhda Global Health Humans Meningococcal Infections Meningococcal Vaccines Neisseria meningitidis Serogroup Background: Meningococcal disease continues to be a global public health concern due to its epidemic potential, severity, and sequelae. The global epidemiological data on circulating meningococcal serogroups have never been reviewed concurrently with the laboratory capacity for meningococcal surveillance at the national level. We, therefore, aimed to conduct a country-level review of meningococcal surveillance, serogroup distribution, and vaccine use. Methods: We conducted a systematic literature review across six databases to identify studies (published January 1, 2010 to October 16, 2017) and grey literature reporting meningococcal serogroup data for the years 2010-2016. We performed independent random effects meta-analyses for serogroups A, B, C, W, X, Y, and other. We developed and circulated a questionnaire-based survey to surveillance focal points in countries (N = 95) with known regional bacterial meningitis surveillance programs to assess their surveillance capacity and summarized using descriptive methods. Results: We included 173 studies from 59 countries in the final analysis. The distribution of meningococcal serogroups differed markedly between countries and regions. Meningococcal serogroups C and W accounted for substantial proportions of meningococcal disease in most of Africa and Latin America. Serogroup B was the predominant cause of meningococcal disease in many locations in Europe, the Americas, and the Western Pacific. Serogroup Y also caused many cases of meningococcal disease in these regions, particularly in Nordic countries. Survey responses were received from 51 countries. All countries reported the ability to confirm the pathogen in-country, while approximately 30% either relied on reference laboratories for serogrouping (N = 10) or did not serogroup specimens (N = 5). Approximately half of countries did not utilize active laboratory-based surveillance system (N = 22). Nationwide use of a meningococcal vaccine varied, but most countries (N = 36) utilized a meningococcal vaccine at least for certain high-risk population groups, in private care, or during outbreaks. Conclusions: Due to the large geographical variations in circulating meningococcal serogroups, each country should continue to be monitored for changes in major disease-causing serogroups in order to inform vaccine and control policies. Similarly, laboratory capacity should be appropriately scaled up to more accurately understand local epidemiology and disease burden, as well as the impact of vaccination programs. Edinburgh University Press http://hdl.handle.net/20.500.12105/7530 |
| spellingShingle | Meningococcal serogroups and surveillance: a systematic review and survey Peterson, Meagan E Global Health Humans Meningococcal Infections Meningococcal Vaccines Neisseria meningitidis Serogroup |
| title | Meningococcal serogroups and surveillance: a systematic review and survey |
| title_full | Meningococcal serogroups and surveillance: a systematic review and survey |
| title_fullStr | Meningococcal serogroups and surveillance: a systematic review and survey |
| title_full_unstemmed | Meningococcal serogroups and surveillance: a systematic review and survey |
| title_short | Meningococcal serogroups and surveillance: a systematic review and survey |
| title_sort | Meningococcal serogroups and surveillance: a systematic review and survey |
| topic | Global Health Humans Meningococcal Infections Meningococcal Vaccines Neisseria meningitidis Serogroup |
| topic_facet | Global Health Humans Meningococcal Infections Meningococcal Vaccines Neisseria meningitidis Serogroup |
| url | http://hdl.handle.net/20.500.12105/7530 |