Alginate Hydrogel Formulation with Ketorolac for the Treatment of Pain Related Sialolithiasis
Abstract: Sialolithiasis mainly affects the oral salivary glands due to the presence of small stones that obstruct the secretion of saliva. The treatment and control of pain and inflammation during the course of this pathology is essential to guarantee the patient's comfort. For this reason, a ketor...
| Autores: | ; ; ; ; ; ; ; |
|---|---|
| Tipo de documento: | Artículo |
| Estado: | Published version |
| Fecha de publicación: | 2023 |
| País: | España |
| Institución: | Universidad de Barcelona |
| Repositorio: | Dipòsit Digital de la UB |
| OAI Identifier: | oai:diposit.ub.edu:2445/200227 |
| Acceso en línea: | https://hdl.handle.net/2445/200227 |
| Nivel de acceso: | Acceso abierto |
| Palabra clave: | Glàndules salivals Gels (Farmàcia) Desenvolupament de medicaments Salivary glands Gels (Pharmacy) Drug development |
| _version_ | 1878738443985485824 |
|---|---|
| author | Silva, Cristina |
| author2 | Ramos Yacasi, Gladys Rosario Mallandrich Miret, Mireia Colom Codina, Helena Suñer Carbó, J. (Joaquim) Noelia Pérez-González Calpena Campmany, Ana Cristina Fernández Campos, Francisco |
| author2_role | author author author author author author author |
| author_browse | Calpena Campmany, Ana Cristina Colom Codina, Helena Fernández Campos, Francisco Mallandrich Miret, Mireia Noelia Pérez-González Ramos Yacasi, Gladys Rosario Silva, Cristina Suñer Carbó, J. (Joaquim) |
| author_facet | Silva, Cristina Ramos Yacasi, Gladys Rosario Mallandrich Miret, Mireia Colom Codina, Helena Suñer Carbó, J. (Joaquim) Noelia Pérez-González Calpena Campmany, Ana Cristina Fernández Campos, Francisco |
| author_role | author |
| collection | Dipòsit Digital de la UB |
| description | Abstract: Sialolithiasis mainly affects the oral salivary glands due to the presence of small stones that obstruct the secretion of saliva. The treatment and control of pain and inflammation during the course of this pathology is essential to guarantee the patient's comfort. For this reason, a ketorolac calcium cross-linked alginate hydrogel was developed, and it was then applied in the area of the buccal cavity. The formulation was characterized (swelling and degradation profile, extrusion, extensibility, surface morphology, viscosity, and drug release). The drug release was studied ex vivo in static Franz cells and with a dynamic ex vivo method under artificial saliva continuous flow. The product exhibits adequate physicochemical properties considering the intended purpose, and the drug concentrations retained in the mucosa were high enough to deliver a therapeutic local concentration able to reduce the pain associated with the patient's conditions. The results confirmed the suitability of the formulation for application in the mouth. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_af190d2fe09dd9ca9f231c78b28d43f9 |
| institution | Universidad de Barcelona |
| instname_str | Universidad de Barcelona |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:diposit.ub.edu:2445/200227 |
| publishDate | 2023 |
| publishDateSort | 2023 |
| reponame_str | Dipòsit Digital de la UB |
| spelling | Alginate Hydrogel Formulation with Ketorolac for the Treatment of Pain Related Sialolithiasis Silva, Cristina Ramos Yacasi, Gladys Rosario Mallandrich Miret, Mireia Colom Codina, Helena Suñer Carbó, J. (Joaquim) Noelia Pérez-González Calpena Campmany, Ana Cristina Fernández Campos, Francisco Glàndules salivals Gels (Farmàcia) Desenvolupament de medicaments Salivary glands Gels (Pharmacy) Drug development Abstract: Sialolithiasis mainly affects the oral salivary glands due to the presence of small stones that obstruct the secretion of saliva. The treatment and control of pain and inflammation during the course of this pathology is essential to guarantee the patient's comfort. For this reason, a ketorolac calcium cross-linked alginate hydrogel was developed, and it was then applied in the area of the buccal cavity. The formulation was characterized (swelling and degradation profile, extrusion, extensibility, surface morphology, viscosity, and drug release). The drug release was studied ex vivo in static Franz cells and with a dynamic ex vivo method under artificial saliva continuous flow. The product exhibits adequate physicochemical properties considering the intended purpose, and the drug concentrations retained in the mucosa were high enough to deliver a therapeutic local concentration able to reduce the pain associated with the patient's conditions. The results confirmed the suitability of the formulation for application in the mouth. https://hdl.handle.net/2445/200227 |
| spellingShingle | Alginate Hydrogel Formulation with Ketorolac for the Treatment of Pain Related Sialolithiasis Silva, Cristina Glàndules salivals Gels (Farmàcia) Desenvolupament de medicaments Salivary glands Gels (Pharmacy) Drug development |
| status_str | publishedVersion |
| title | Alginate Hydrogel Formulation with Ketorolac for the Treatment of Pain Related Sialolithiasis |
| title_full | Alginate Hydrogel Formulation with Ketorolac for the Treatment of Pain Related Sialolithiasis |
| title_fullStr | Alginate Hydrogel Formulation with Ketorolac for the Treatment of Pain Related Sialolithiasis |
| title_full_unstemmed | Alginate Hydrogel Formulation with Ketorolac for the Treatment of Pain Related Sialolithiasis |
| title_short | Alginate Hydrogel Formulation with Ketorolac for the Treatment of Pain Related Sialolithiasis |
| title_sort | Alginate Hydrogel Formulation with Ketorolac for the Treatment of Pain Related Sialolithiasis |
| topic | Glàndules salivals Gels (Farmàcia) Desenvolupament de medicaments Salivary glands Gels (Pharmacy) Drug development |
| topic_facet | Glàndules salivals Gels (Farmàcia) Desenvolupament de medicaments Salivary glands Gels (Pharmacy) Drug development |
| url | https://hdl.handle.net/2445/200227 |