Impact of Applying the Global Lung Initiative Criteria for Airway Obstruction in GOLD Defined COPD Cohorts
Introduction: The Global Lung Function Initiative (GLI) has proposed new criteria for airflow limitation (AL) and recommends using these to interpret spirometry. The objective of this study was to explore the impact of the application of the AL GLI criteria in two well characterized GOLD-defined COP...
| Autores: | ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; |
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| Tipo de documento: | Artículo |
| Fecha de publicación: | 2024 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Lenguaje: | Inglés |
| OAI Identifier: | oai:ddd.uab.cat:304049 |
| Acceso en línea: | https://ddd.uab.cat/record/304049 https://dx.doi.org/urn:doi:10.1016/j.arbres.2023.10.002 |
| Nivel de acceso: | Acceso abierto |
| Palabra clave: | Airway obstruction Application COPD Clinical Global Lung Function Initiative Mortality |
| _version_ | 1878738427886698496 |
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| author | De Torres, Juan Pablo|||0000-0003-1231-4894 |
| author2 | Casanova Macario, Ciro Marín, José María Cabrera-Lopez, Carlos|||0000-0002-6251-4854 Marín, Marta Ezponda, Ana|||0000-0001-5502-2547 Cosio, Borja G.|||0000-0002-6388-8209 Martínez-González, Cristina|||0000-0002-0369-4920 Solanes García, Ingrid|||0000-0001-8506-908X Fuster, Antonia Calle Rubio, Myriam|||0000-0002-3890-2742 Peces-Barba, German|||0000-0002-4436-8443 Gotera-Rivera, Carolina Feu-Collado, Nuria Marin, Alicia Alcaide, Ana Belén Sangro, Matilde Bastarrika, Gorka Celli, Bartolomé R.|||0000-0002-7266-8371 |
| author2_role | author author author author author author author author author author author author author author author author author author |
| author_browse | Alcaide, Ana Belén Bastarrika, Gorka Cabrera-Lopez, Carlos|||0000-0002-6251-4854 Calle Rubio, Myriam|||0000-0002-3890-2742 Casanova Macario, Ciro Celli, Bartolomé R.|||0000-0002-7266-8371 Cosio, Borja G.|||0000-0002-6388-8209 De Torres, Juan Pablo|||0000-0003-1231-4894 Ezponda, Ana|||0000-0001-5502-2547 Feu-Collado, Nuria Fuster, Antonia Gotera-Rivera, Carolina Marin, Alicia Martínez-González, Cristina|||0000-0002-0369-4920 Marín, José María Marín, Marta Peces-Barba, German|||0000-0002-4436-8443 Sangro, Matilde Solanes García, Ingrid|||0000-0001-8506-908X |
| author_facet | De Torres, Juan Pablo|||0000-0003-1231-4894 Casanova Macario, Ciro Marín, José María Cabrera-Lopez, Carlos|||0000-0002-6251-4854 Marín, Marta Ezponda, Ana|||0000-0001-5502-2547 Cosio, Borja G.|||0000-0002-6388-8209 Martínez-González, Cristina|||0000-0002-0369-4920 Solanes García, Ingrid|||0000-0001-8506-908X Fuster, Antonia Calle Rubio, Myriam|||0000-0002-3890-2742 Peces-Barba, German|||0000-0002-4436-8443 Gotera-Rivera, Carolina Feu-Collado, Nuria Marin, Alicia Alcaide, Ana Belén Sangro, Matilde Bastarrika, Gorka Celli, Bartolomé R.|||0000-0002-7266-8371 |
| author_role | author |
| collection | Dipòsit Digital de Documents de la UAB |
| description | Introduction: The Global Lung Function Initiative (GLI) has proposed new criteria for airflow limitation (AL) and recommends using these to interpret spirometry. The objective of this study was to explore the impact of the application of the AL GLI criteria in two well characterized GOLD-defined COPD cohorts. Methods: COPD patients from the BODE (n = 360) and the COPD History Assessment In SpaiN (CHAIN) cohorts (n = 722) were enrolled and followed. Age, gender, pack-years history, BMI, dyspnea, lung function measurements, exercise capacity, BODE index, history of exacerbations and survival were recorded. CT-detected comorbidities were registered in the BODE cohort. The proportion of subjects without AL by GLI criteria was determined in each cohort. The clinical, CT-detected comorbidity, and overall survival of these patients were evaluated. Results: In total, 18% of the BODE and 15% of the CHAIN cohort did not meet GLI AL criteria. In the BODE and CHAIN cohorts respectively, these patients had a high clinical burden (BODE ≥ 3: 9% and 20%; mMRC ≥ 2: 16% and 45%; exacerbations in the previous year: 31% and 9%; 6MWD < 350 m: 15% and 19%, respectively), and a similar prevalence of CT-diagnosed comorbidities compared with those with GLI AL. They also had a higher rate of long-term mortality - 33% and 22% respectively. Conclusions: An important proportion of patients from 2 GOLD-defined COPD cohorts did not meet GLI AL criteria at enrolment, although they had a significant burden of disease. Caution must be taken when applying the GLI AL criteria in clinical practice. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_aed7c1eeabb8c99ae2eac2cd11433b18 |
| institution | Universitat Autònoma de Barcelona |
| instname_str | Universitat Autònoma de Barcelona |
| language | eng |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:ddd.uab.cat:304049 |
| publishDate | 2024 |
| publishDateSort | 2024 |
| reponame_str | Dipòsit Digital de Documents de la UAB |
| spelling | Impact of Applying the Global Lung Initiative Criteria for Airway Obstruction in GOLD Defined COPD Cohorts The BODE and CHAIN Experience De Torres, Juan Pablo|||0000-0003-1231-4894 Casanova Macario, Ciro Marín, José María Cabrera-Lopez, Carlos|||0000-0002-6251-4854 Marín, Marta Ezponda, Ana|||0000-0001-5502-2547 Cosio, Borja G.|||0000-0002-6388-8209 Martínez-González, Cristina|||0000-0002-0369-4920 Solanes García, Ingrid|||0000-0001-8506-908X Fuster, Antonia Calle Rubio, Myriam|||0000-0002-3890-2742 Peces-Barba, German|||0000-0002-4436-8443 Gotera-Rivera, Carolina Feu-Collado, Nuria Marin, Alicia Alcaide, Ana Belén Sangro, Matilde Bastarrika, Gorka Celli, Bartolomé R.|||0000-0002-7266-8371 Airway obstruction Application COPD Clinical Global Lung Function Initiative Mortality Introduction: The Global Lung Function Initiative (GLI) has proposed new criteria for airflow limitation (AL) and recommends using these to interpret spirometry. The objective of this study was to explore the impact of the application of the AL GLI criteria in two well characterized GOLD-defined COPD cohorts. Methods: COPD patients from the BODE (n = 360) and the COPD History Assessment In SpaiN (CHAIN) cohorts (n = 722) were enrolled and followed. Age, gender, pack-years history, BMI, dyspnea, lung function measurements, exercise capacity, BODE index, history of exacerbations and survival were recorded. CT-detected comorbidities were registered in the BODE cohort. The proportion of subjects without AL by GLI criteria was determined in each cohort. The clinical, CT-detected comorbidity, and overall survival of these patients were evaluated. Results: In total, 18% of the BODE and 15% of the CHAIN cohort did not meet GLI AL criteria. In the BODE and CHAIN cohorts respectively, these patients had a high clinical burden (BODE ≥ 3: 9% and 20%; mMRC ≥ 2: 16% and 45%; exacerbations in the previous year: 31% and 9%; 6MWD < 350 m: 15% and 19%, respectively), and a similar prevalence of CT-diagnosed comorbidities compared with those with GLI AL. They also had a higher rate of long-term mortality - 33% and 22% respectively. Conclusions: An important proportion of patients from 2 GOLD-defined COPD cohorts did not meet GLI AL criteria at enrolment, although they had a significant burden of disease. Caution must be taken when applying the GLI AL criteria in clinical practice. https://ddd.uab.cat/record/304049 https://dx.doi.org/urn:doi:10.1016/j.arbres.2023.10.002 |
| spellingShingle | Impact of Applying the Global Lung Initiative Criteria for Airway Obstruction in GOLD Defined COPD Cohorts De Torres, Juan Pablo|||0000-0003-1231-4894 Airway obstruction Application COPD Clinical Global Lung Function Initiative Mortality |
| title | Impact of Applying the Global Lung Initiative Criteria for Airway Obstruction in GOLD Defined COPD Cohorts |
| title_full | Impact of Applying the Global Lung Initiative Criteria for Airway Obstruction in GOLD Defined COPD Cohorts |
| title_fullStr | Impact of Applying the Global Lung Initiative Criteria for Airway Obstruction in GOLD Defined COPD Cohorts |
| title_full_unstemmed | Impact of Applying the Global Lung Initiative Criteria for Airway Obstruction in GOLD Defined COPD Cohorts |
| title_short | Impact of Applying the Global Lung Initiative Criteria for Airway Obstruction in GOLD Defined COPD Cohorts |
| title_sort | Impact of Applying the Global Lung Initiative Criteria for Airway Obstruction in GOLD Defined COPD Cohorts |
| topic | Airway obstruction Application COPD Clinical Global Lung Function Initiative Mortality |
| topic_facet | Airway obstruction Application COPD Clinical Global Lung Function Initiative Mortality |
| url | https://ddd.uab.cat/record/304049 https://dx.doi.org/urn:doi:10.1016/j.arbres.2023.10.002 |