Mouthwash Formulation Co-Delivering Quercetin and Mint Oil in Liposomes Improved with Glycol and Ethanol and Tailored for Protecting and Tackling Oral Cavity
: The aim of this work was the simultaneous loading of quercetin and mint essential oil (mint oil) in phospholipid vesicles specifically tailored to obtain an antibacterial and antioxidant mouthwash. The vesicles were prepared using soy lecithin and Tween 80 as bilayer components, and a mixture of p...
| Authors: | ; ; ; ; ; ; ; ; ; ; |
|---|---|
| Format: | Article |
| Status: | Published version |
| Publication date: | 2022 |
| Country: | España |
| Institution: | Universidad de Barcelona |
| Repository: | Dipòsit Digital de la UB |
| OAI Identifier: | oai:diposit.ub.edu:2445/185875 |
| Online Access: | https://hdl.handle.net/2445/185875 |
| Access Level: | Open access |
| Keyword: | Olis essencials Malalties de la boca Estreptococs Essences and essential oils Mouth diseases Streptococcus |
| _version_ | 1878738427702149120 |
|---|---|
| author | Castangia, Ines |
| author2 | Manconi, Maria Allaw, Mohamad Perra, Matteo Orrù, Germano Fais, Sara Scano, Alessandra Escribano Ferrer, Elvira Ghavam, Mansureh Rezvani, Maryam Manca, Maria Letizia |
| author2_role | author author author author author author author author author author |
| author_browse | Allaw, Mohamad Castangia, Ines Escribano Ferrer, Elvira Fais, Sara Ghavam, Mansureh Manca, Maria Letizia Manconi, Maria Orrù, Germano Perra, Matteo Rezvani, Maryam Scano, Alessandra |
| author_facet | Castangia, Ines Manconi, Maria Allaw, Mohamad Perra, Matteo Orrù, Germano Fais, Sara Scano, Alessandra Escribano Ferrer, Elvira Ghavam, Mansureh Rezvani, Maryam Manca, Maria Letizia |
| author_role | author |
| collection | Dipòsit Digital de la UB |
| description | : The aim of this work was the simultaneous loading of quercetin and mint essential oil (mint oil) in phospholipid vesicles specifically tailored to obtain an antibacterial and antioxidant mouthwash. The vesicles were prepared using soy lecithin and Tween 80 as bilayer components, and a mixture of phosphate buffer solution (33%), propylene glycol (33%) and ethanol (33%) as dispersing phase. The formation of regularly shaped, spherical and unilamellar vesicles was confirmed by cryogenic transmission electron microscopy analyses. Similarly, light scattering results disclosed that the size of the vesicles increased by increasing the concentration of mint oil, but at the same time the high amount of mint oil ensured high stability, as the size of these vesicles remained unchanged during 12 months of storage. All tested formulations were highly biocompatible towards epithelial cells and capable of counteracting oxidative cell damages caused by hydrogen peroxide. Moreover, the vesicles prepared with the highest concentration of mint oil inhibited the proliferation of the cariogenic Streptococcus mutans (S. mutans) and Lactobacillus acidophilus (L. acidophilus). |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_aed362a83e466f04f2fedfd2aa7b2c8b |
| institution | Universidad de Barcelona |
| instname_str | Universidad de Barcelona |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:diposit.ub.edu:2445/185875 |
| publishDate | 2022 |
| publishDateSort | 2022 |
| publisher | MDPI |
| publisherStr | MDPI |
| reponame_str | Dipòsit Digital de la UB |
| spelling | Mouthwash Formulation Co-Delivering Quercetin and Mint Oil in Liposomes Improved with Glycol and Ethanol and Tailored for Protecting and Tackling Oral Cavity Castangia, Ines Manconi, Maria Allaw, Mohamad Perra, Matteo Orrù, Germano Fais, Sara Scano, Alessandra Escribano Ferrer, Elvira Ghavam, Mansureh Rezvani, Maryam Manca, Maria Letizia Olis essencials Malalties de la boca Estreptococs Essences and essential oils Mouth diseases Streptococcus : The aim of this work was the simultaneous loading of quercetin and mint essential oil (mint oil) in phospholipid vesicles specifically tailored to obtain an antibacterial and antioxidant mouthwash. The vesicles were prepared using soy lecithin and Tween 80 as bilayer components, and a mixture of phosphate buffer solution (33%), propylene glycol (33%) and ethanol (33%) as dispersing phase. The formation of regularly shaped, spherical and unilamellar vesicles was confirmed by cryogenic transmission electron microscopy analyses. Similarly, light scattering results disclosed that the size of the vesicles increased by increasing the concentration of mint oil, but at the same time the high amount of mint oil ensured high stability, as the size of these vesicles remained unchanged during 12 months of storage. All tested formulations were highly biocompatible towards epithelial cells and capable of counteracting oxidative cell damages caused by hydrogen peroxide. Moreover, the vesicles prepared with the highest concentration of mint oil inhibited the proliferation of the cariogenic Streptococcus mutans (S. mutans) and Lactobacillus acidophilus (L. acidophilus). MDPI https://hdl.handle.net/2445/185875 |
| spellingShingle | Mouthwash Formulation Co-Delivering Quercetin and Mint Oil in Liposomes Improved with Glycol and Ethanol and Tailored for Protecting and Tackling Oral Cavity Castangia, Ines Olis essencials Malalties de la boca Estreptococs Essences and essential oils Mouth diseases Streptococcus |
| status_str | publishedVersion |
| title | Mouthwash Formulation Co-Delivering Quercetin and Mint Oil in Liposomes Improved with Glycol and Ethanol and Tailored for Protecting and Tackling Oral Cavity |
| title_full | Mouthwash Formulation Co-Delivering Quercetin and Mint Oil in Liposomes Improved with Glycol and Ethanol and Tailored for Protecting and Tackling Oral Cavity |
| title_fullStr | Mouthwash Formulation Co-Delivering Quercetin and Mint Oil in Liposomes Improved with Glycol and Ethanol and Tailored for Protecting and Tackling Oral Cavity |
| title_full_unstemmed | Mouthwash Formulation Co-Delivering Quercetin and Mint Oil in Liposomes Improved with Glycol and Ethanol and Tailored for Protecting and Tackling Oral Cavity |
| title_short | Mouthwash Formulation Co-Delivering Quercetin and Mint Oil in Liposomes Improved with Glycol and Ethanol and Tailored for Protecting and Tackling Oral Cavity |
| title_sort | Mouthwash Formulation Co-Delivering Quercetin and Mint Oil in Liposomes Improved with Glycol and Ethanol and Tailored for Protecting and Tackling Oral Cavity |
| topic | Olis essencials Malalties de la boca Estreptococs Essences and essential oils Mouth diseases Streptococcus |
| topic_facet | Olis essencials Malalties de la boca Estreptococs Essences and essential oils Mouth diseases Streptococcus |
| url | https://hdl.handle.net/2445/185875 |