Histological response to radiotherapy is an early event in myxoid liposarcoma
Myxoid liposarcoma; Personalized medicine; Radiotherapy
| Authors: | ; ; ; ; ; |
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| Format: | Article |
| Status: | Published version |
| Publication date: | 2023 |
| Country: | España |
| Institution: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repository: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:11351/10664 |
| Online Access: | https://hdl.handle.net/11351/10664 http://hdl.handle.net/11351/10664 |
| Access Level: | Open access |
| Keyword: | Teixit adipós - Càncer - Radioteràpia Apoptosi DISEASES::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Connective and Soft Tissue::Neoplasms, Adipose Tissue::Liposarcoma::Liposarcoma, Myxoid ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Radiotherapy PHENOMENA AND PROCESSES::Cell Physiological Phenomena::Cell Death::Apoptosis ENFERMEDADES::neoplasias::neoplasias por tipo histológico::neoplasias de tejido conjuntivo y de tejidos blandos::neoplasias de tejido adiposo::liposarcoma::liposarcoma mixoide TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::radioterapia FENÓMENOS Y PROCESOS::fenómenos fisiológicos celulares::muerte celular::apoptosis |
| _version_ | 1878738407041007616 |
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| author | Lam, Suk Wai |
| author2 | Silva, Tulio M. Traast-Kooistra, Jolanda Briaire de Bruijn, Inge H. van den Akker, Brendy Bakker, Pauline A. C. |
| author2_role | author author author author author |
| author_browse | Bakker, Pauline A. C. Briaire de Bruijn, Inge H. Lam, Suk Wai Silva, Tulio M. Traast-Kooistra, Jolanda van den Akker, Brendy |
| author_facet | Lam, Suk Wai Silva, Tulio M. Traast-Kooistra, Jolanda Briaire de Bruijn, Inge H. van den Akker, Brendy Bakker, Pauline A. C. |
| author_role | author |
| collection | Recercat. Dipósit de la Recerca de Catalunya |
| description | Myxoid liposarcoma; Personalized medicine; Radiotherapy |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_ae7e4ec3846da514b9c0223ec75ad1d2 |
| institution | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| instname_str | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:recercat.cat:11351/10664 |
| publishDate | 2023 |
| publishDateSort | 2023 |
| publisher | Springer |
| publisherStr | Springer |
| reponame_str | Recercat. Dipósit de la Recerca de Catalunya |
| spelling | Histological response to radiotherapy is an early event in myxoid liposarcoma Lam, Suk Wai Silva, Tulio M. Traast-Kooistra, Jolanda Briaire de Bruijn, Inge H. van den Akker, Brendy Bakker, Pauline A. C. Teixit adipós - Càncer - Radioteràpia Apoptosi DISEASES::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Connective and Soft Tissue::Neoplasms, Adipose Tissue::Liposarcoma::Liposarcoma, Myxoid ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Radiotherapy PHENOMENA AND PROCESSES::Cell Physiological Phenomena::Cell Death::Apoptosis ENFERMEDADES::neoplasias::neoplasias por tipo histológico::neoplasias de tejido conjuntivo y de tejidos blandos::neoplasias de tejido adiposo::liposarcoma::liposarcoma mixoide TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::radioterapia FENÓMENOS Y PROCESOS::fenómenos fisiológicos celulares::muerte celular::apoptosis Myxoid liposarcoma; Personalized medicine; Radiotherapy Liposarcoma mixoide; Medicina personalizada; Radioterapia Liposarcoma mixoide; Medicina personalitzada; Radioteràpia Compared to other sarcomas, myxoid liposarcoma (MLS) is exceptionally sensitive to radiation therapy, but the underlying mechanism remains unknown. The objective was to assess the tissue-based changes in MLS during and after neoadjuvant radiotherapy in 26 patients of the DOREMY trial. Morphological assessment was performed on biopsies pre-treatment, after 8 fractions, 16 factions, and after surgical resection and included percentage of viable tumor cells, hyalinization, necrosis, and fatty maturation. Furthermore, immunohistochemistry was performed for apoptosis (cleaved caspase-3), anti-apoptosis (Bcl-2), activity of mTOR signaling (phospho-S6), hypoxia (CAIX), proliferation (Ki67), inflammation (CD45 and CD68), and microvessel density (CD34 Chalkley count). A pronounced reduction in vital tumor cells was observed early with a drop to 32.5% (median) tumor cells (IQR 10–93.8%) after 8 fractions. This decreased further to 10% (IQR 5–30%) after 16 fractions and 7.5% (IQR 5–15%) in the surgical specimen. All but one patient had an excellent response with < 50% remaining tumor cells. Inversely, treatment response was mainly observed as hyalinization and less often as fatty maturation. Additionally, a decrease of inflammatory cells was noticed especially during the first eight fractions. Microvessel density remained stable over time. Immunohistochemical markers for apoptosis, anti-apoptosis, activity of mTOR signaling, proliferation, and hypoxia did not show any marked changes within the remaining tumor cells during and after radiotherapy. As a modest dose of neoadjuvant radiotherapy induces profound tissue changes in MLS, mainly during the first 8 fractions, current findings might suggest that in a carefully selected patient population further deintensification of radiotherapy might be explored. Springer https://hdl.handle.net/11351/10664 http://hdl.handle.net/11351/10664 |
| spellingShingle | Histological response to radiotherapy is an early event in myxoid liposarcoma Lam, Suk Wai Teixit adipós - Càncer - Radioteràpia Apoptosi DISEASES::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Connective and Soft Tissue::Neoplasms, Adipose Tissue::Liposarcoma::Liposarcoma, Myxoid ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Radiotherapy PHENOMENA AND PROCESSES::Cell Physiological Phenomena::Cell Death::Apoptosis ENFERMEDADES::neoplasias::neoplasias por tipo histológico::neoplasias de tejido conjuntivo y de tejidos blandos::neoplasias de tejido adiposo::liposarcoma::liposarcoma mixoide TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::radioterapia FENÓMENOS Y PROCESOS::fenómenos fisiológicos celulares::muerte celular::apoptosis |
| status_str | publishedVersion |
| title | Histological response to radiotherapy is an early event in myxoid liposarcoma |
| title_full | Histological response to radiotherapy is an early event in myxoid liposarcoma |
| title_fullStr | Histological response to radiotherapy is an early event in myxoid liposarcoma |
| title_full_unstemmed | Histological response to radiotherapy is an early event in myxoid liposarcoma |
| title_short | Histological response to radiotherapy is an early event in myxoid liposarcoma |
| title_sort | Histological response to radiotherapy is an early event in myxoid liposarcoma |
| topic | Teixit adipós - Càncer - Radioteràpia Apoptosi DISEASES::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Connective and Soft Tissue::Neoplasms, Adipose Tissue::Liposarcoma::Liposarcoma, Myxoid ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Radiotherapy PHENOMENA AND PROCESSES::Cell Physiological Phenomena::Cell Death::Apoptosis ENFERMEDADES::neoplasias::neoplasias por tipo histológico::neoplasias de tejido conjuntivo y de tejidos blandos::neoplasias de tejido adiposo::liposarcoma::liposarcoma mixoide TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::radioterapia FENÓMENOS Y PROCESOS::fenómenos fisiológicos celulares::muerte celular::apoptosis |
| topic_facet | Teixit adipós - Càncer - Radioteràpia Apoptosi DISEASES::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Connective and Soft Tissue::Neoplasms, Adipose Tissue::Liposarcoma::Liposarcoma, Myxoid ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Radiotherapy PHENOMENA AND PROCESSES::Cell Physiological Phenomena::Cell Death::Apoptosis ENFERMEDADES::neoplasias::neoplasias por tipo histológico::neoplasias de tejido conjuntivo y de tejidos blandos::neoplasias de tejido adiposo::liposarcoma::liposarcoma mixoide TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::radioterapia FENÓMENOS Y PROCESOS::fenómenos fisiológicos celulares::muerte celular::apoptosis |
| url | https://hdl.handle.net/11351/10664 http://hdl.handle.net/11351/10664 |