Gender differences in patients with Brugada syndrome and arrhythmic events: Data from a survey on arrhythmic events in 678 patients
BACKGROUND There is limited information on gender differences in patients with Brugada syndrome (BrS) who experienced arrhythmic events (AEs). OBJECTIVE The purpose of this study was to compare clinical, electrocardiographic (ECG), electrophysiological, and genetic characteristics between males and...
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| Format: | Article |
| Status: | Published version |
| Publication date: | 2018 |
| Country: | España |
| Institution: | Fundació Sant Joan de Déu |
| Repository: | r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu |
| OAI Identifier: | oai:fsjd.fundanetsuite.com:p14546 |
| Online Access: | https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=14546 |
| Access Level: | Open access |
| Keyword: | Brugada ECG Ethnicity Implantable cardioverter-de-fibrillator Ethnicity SCN5A mutation Sudden cardiac death |
| _version_ | 1878738399162007552 |
|---|---|
| author | Milman A |
| author2 | Gourraud JB Andorin A Postema PG Sacher F Mabo P Conte G Giustetto C Sarquella-Brugada G Hochstadt A Kim SH Juang JJ Maeda S Takahashi Y Kamakura T Aiba T Leshem E Michowitz Y Rahkovich M Mizusawa Y Arbelo E Huang Z Denjoy I Wijeyeratne YD Napolitano C Brugada R Casado-Arroyo R Champagne J Calo L Tfelt-Hansen J Priori SG Takagi M Veltmann C Delise P Corrado D Behr ER Gaita F Yan GX Brugada J Leenhardt A Wilde AAM Brugada P Kusano KF Hirao K Nam GB Probst V Belhassen B |
| author2_role | author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| author_browse | Aiba T Andorin A Arbelo E Behr ER Belhassen B Brugada J Brugada P Brugada R Calo L Casado-Arroyo R Champagne J Conte G Corrado D Delise P Denjoy I Gaita F Giustetto C Gourraud JB Hirao K Hochstadt A Huang Z Juang JJ Kamakura T Kim SH Kusano KF Leenhardt A Leshem E Mabo P Maeda S Michowitz Y Milman A Mizusawa Y Nam GB Napolitano C Postema PG Priori SG Probst V Rahkovich M Sacher F Sarquella-Brugada G Takagi M Takahashi Y Tfelt-Hansen J Veltmann C Wijeyeratne YD Wilde AAM Yan GX |
| author_facet | Milman A Gourraud JB Andorin A Postema PG Sacher F Mabo P Conte G Giustetto C Sarquella-Brugada G Hochstadt A Kim SH Juang JJ Maeda S Takahashi Y Kamakura T Aiba T Leshem E Michowitz Y Rahkovich M Mizusawa Y Arbelo E Huang Z Denjoy I Wijeyeratne YD Napolitano C Brugada R Casado-Arroyo R Champagne J Calo L Tfelt-Hansen J Priori SG Takagi M Veltmann C Delise P Corrado D Behr ER Gaita F Yan GX Brugada J Leenhardt A Wilde AAM Brugada P Kusano KF Hirao K Nam GB Probst V Belhassen B |
| author_role | author |
| collection | r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu |
| description | BACKGROUND There is limited information on gender differences in patients with Brugada syndrome (BrS) who experienced arrhythmic events (AEs). OBJECTIVE The purpose of this study was to compare clinical, electrocardiographic (ECG), electrophysiological, and genetic characteristics between males and females in patients with BrS with their first AE. METHODS The multicenter Survey on Arrhythmic Events in BRUgada Syndrome collected data on the first AE in 678 patients with BrS including 619 males (91.3%) and 59 females (8.7%) aged 0.27-84 years (mean age 42.5 +/- 14.1 years) at the time of AE occurrence. RESULTS After excluding pediatric patients, it was found that females were older than males (49.5 +/- 14.4 years vs 43 +/- 12.7 years, respectively; P = .001). Higher proportions of females were observed in the pediatric and elderly populations. In Asians, the male to female ratio for AEs was approximate to 9-fold higher than that in White. Spontaneous type 1 BrS ECG was associated with an earlier onset of AEs in pediatric females. A similar prevalence (approximate to 65%) of spontaneous type 1 BrS ECG was present in males and females above the age of 60 years. Females less frequently showed spontaneous type 1 BrS ECG (41% vs 69%; P < .001) or arrhythmia inducibility at electrophysiology study (36% vs 66%; P < .001). An SCN5A mutation was more frequently found in females (48% vs 28% in males; P = .007). CONCLUSION This study confirms that female patients with BrS are much rarer, display less type 1 Brugada ECG, and exhibit lower inducibility rates than domales. It shows for the first time that female patients with BrS with AE have higher SCN5A mutation rates as well as the relationship between gender vs age at the onset of AEs and ethnicity. (C) 2018 Heart Rhythm Society. All rights reserved. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_ae5a2d0c0f3eba2ed4c19cb5fc999cb6 |
| institution | Fundació Sant Joan de Déu |
| instname_str | Fundació Sant Joan de Déu |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:fsjd.fundanetsuite.com:p14546 |
| publishDate | 2018 |
| publishDateSort | 2018 |
| publisher | ELSEVIER SCIENCE INC |
| publisherStr | ELSEVIER SCIENCE INC |
| reponame_str | r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu |
| spelling | Gender differences in patients with Brugada syndrome and arrhythmic events: Data from a survey on arrhythmic events in 678 patients Milman A Gourraud JB Andorin A Postema PG Sacher F Mabo P Conte G Giustetto C Sarquella-Brugada G Hochstadt A Kim SH Juang JJ Maeda S Takahashi Y Kamakura T Aiba T Leshem E Michowitz Y Rahkovich M Mizusawa Y Arbelo E Huang Z Denjoy I Wijeyeratne YD Napolitano C Brugada R Casado-Arroyo R Champagne J Calo L Tfelt-Hansen J Priori SG Takagi M Veltmann C Delise P Corrado D Behr ER Gaita F Yan GX Brugada J Leenhardt A Wilde AAM Brugada P Kusano KF Hirao K Nam GB Probst V Belhassen B Brugada ECG Ethnicity Implantable cardioverter-de-fibrillator Ethnicity SCN5A mutation Sudden cardiac death BACKGROUND There is limited information on gender differences in patients with Brugada syndrome (BrS) who experienced arrhythmic events (AEs). OBJECTIVE The purpose of this study was to compare clinical, electrocardiographic (ECG), electrophysiological, and genetic characteristics between males and females in patients with BrS with their first AE. METHODS The multicenter Survey on Arrhythmic Events in BRUgada Syndrome collected data on the first AE in 678 patients with BrS including 619 males (91.3%) and 59 females (8.7%) aged 0.27-84 years (mean age 42.5 +/- 14.1 years) at the time of AE occurrence. RESULTS After excluding pediatric patients, it was found that females were older than males (49.5 +/- 14.4 years vs 43 +/- 12.7 years, respectively; P = .001). Higher proportions of females were observed in the pediatric and elderly populations. In Asians, the male to female ratio for AEs was approximate to 9-fold higher than that in White. Spontaneous type 1 BrS ECG was associated with an earlier onset of AEs in pediatric females. A similar prevalence (approximate to 65%) of spontaneous type 1 BrS ECG was present in males and females above the age of 60 years. Females less frequently showed spontaneous type 1 BrS ECG (41% vs 69%; P < .001) or arrhythmia inducibility at electrophysiology study (36% vs 66%; P < .001). An SCN5A mutation was more frequently found in females (48% vs 28% in males; P = .007). CONCLUSION This study confirms that female patients with BrS are much rarer, display less type 1 Brugada ECG, and exhibit lower inducibility rates than domales. It shows for the first time that female patients with BrS with AE have higher SCN5A mutation rates as well as the relationship between gender vs age at the onset of AEs and ethnicity. (C) 2018 Heart Rhythm Society. All rights reserved. ELSEVIER SCIENCE INC https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=14546 |
| spellingShingle | Gender differences in patients with Brugada syndrome and arrhythmic events: Data from a survey on arrhythmic events in 678 patients Milman A Brugada ECG Ethnicity Implantable cardioverter-de-fibrillator Ethnicity SCN5A mutation Sudden cardiac death |
| status_str | publishedVersion |
| title | Gender differences in patients with Brugada syndrome and arrhythmic events: Data from a survey on arrhythmic events in 678 patients |
| title_full | Gender differences in patients with Brugada syndrome and arrhythmic events: Data from a survey on arrhythmic events in 678 patients |
| title_fullStr | Gender differences in patients with Brugada syndrome and arrhythmic events: Data from a survey on arrhythmic events in 678 patients |
| title_full_unstemmed | Gender differences in patients with Brugada syndrome and arrhythmic events: Data from a survey on arrhythmic events in 678 patients |
| title_short | Gender differences in patients with Brugada syndrome and arrhythmic events: Data from a survey on arrhythmic events in 678 patients |
| title_sort | Gender differences in patients with Brugada syndrome and arrhythmic events: Data from a survey on arrhythmic events in 678 patients |
| topic | Brugada ECG Ethnicity Implantable cardioverter-de-fibrillator Ethnicity SCN5A mutation Sudden cardiac death |
| topic_facet | Brugada ECG Ethnicity Implantable cardioverter-de-fibrillator Ethnicity SCN5A mutation Sudden cardiac death |
| url | https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=14546 |