Inhibitory Role of Growth Hormone in the Induction and Progression Phases of Collagen-Induced Arthritis
Evidence indicates an intimate connection between the neuroendocrine and the immune systems. A number of in vitro and in vivo studies have demonstrated growth hormone (GH) involvement in immune regulation. The GH receptor is expressed by several leukocyte subpopulations, and GH modulates immune cell...
| Authors: | ; ; ; ; ; ; ; ; ; ; ; ; |
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| Format: | Article |
| Publication date: | 2018 |
| Country: | España |
| Institution: | Universidad Complutense de Madrid (UCM) |
| Repository: | Docta Complutense |
| Language: | English |
| OAI Identifier: | oai:docta.ucm.es:20.500.14352/13484 |
| Online Access: | https://hdl.handle.net/20.500.14352/13484 |
| Access Level: | Open access |
| Keyword: | 577.17 616.72-002 577.27 Collagen-induced arthritis Growth hormone Th17/Th1 cells Cytokines Immune regulation Bioquímica (Medicina) Inmunología Reumatología 2412 Inmunología 3205.09 Reumatología |
| _version_ | 1878738160046833664 |
|---|---|
| author | Villares, Ricardo |
| author2 | Criado, Gabriel Juarranz Moratilla, Yasmina López Santalla, Mercedes García Cuesta, Eva María Rodríguez Frade, José Miguel Leceta Martínez, Javier Lucas, Pilar Pablos Álvarez, José Luis Martínez-A., Carlos Garín, Marina I. Gomáriz, Rosa P. Mellado, Mario |
| author2_role | author author author author author author author author author author author author |
| author_browse | Criado, Gabriel García Cuesta, Eva María Garín, Marina I. Gomáriz, Rosa P. Juarranz Moratilla, Yasmina Leceta Martínez, Javier Lucas, Pilar López Santalla, Mercedes Martínez-A., Carlos Mellado, Mario Pablos Álvarez, José Luis Rodríguez Frade, José Miguel Villares, Ricardo |
| author_facet | Villares, Ricardo Criado, Gabriel Juarranz Moratilla, Yasmina López Santalla, Mercedes García Cuesta, Eva María Rodríguez Frade, José Miguel Leceta Martínez, Javier Lucas, Pilar Pablos Álvarez, José Luis Martínez-A., Carlos Garín, Marina I. Gomáriz, Rosa P. Mellado, Mario |
| author_role | author |
| collection | Docta Complutense |
| description | Evidence indicates an intimate connection between the neuroendocrine and the immune systems. A number of in vitro and in vivo studies have demonstrated growth hormone (GH) involvement in immune regulation. The GH receptor is expressed by several leukocyte subpopulations, and GH modulates immune cell proliferation and activity. Here, we found that sustained GH expression protected against collagen-induced arthritis (CIA); in GH-transgenic C57BL/6 (GHTg) mice, disease onset was delayed, and its overall severity was decreased. The anti-collagen response was impaired in these mice, as were inflammatory cytokine levels. Compared to control arthritic littermates, immunized GHTg mice showed significantly lower RORγt (retinoic acid receptor-related orphan receptor gamma 2), IL-17, GM-CSF, IL-22, and IFNγ mRNA expression in draining lymph nodes, whereas there were no differences in IL-21, IL-6, or IL-2 mRNA levels. Data thus suggest that Th17/Th1 cell plasticity toward a pathological phenotype is reduced in these mice. Exogenous GH administration in arthritic DBA/1J mice reduced the severity of established CIA as well as the inflammatory environment, which also shows a GH effect on arthritis progression. These results indicate that GH prevents inflammatory joint destruction in CIA. Our findings demonstrate a modulatory GH role in immune system function that contributes to alleviating CIA symptoms and underlines the importance of endocrine regulation of the immune response. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_aa8d75297be467fbc5cdce97d2a8beef |
| institution | Universidad Complutense de Madrid (UCM) |
| instname_str | Universidad Complutense de Madrid (UCM) |
| language | eng |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:docta.ucm.es:20.500.14352/13484 |
| publishDate | 2018 |
| publishDateSort | 2018 |
| publisher | Frontiers Media |
| publisherStr | Frontiers Media |
| reponame_str | Docta Complutense |
| spelling | Inhibitory Role of Growth Hormone in the Induction and Progression Phases of Collagen-Induced Arthritis Villares, Ricardo Criado, Gabriel Juarranz Moratilla, Yasmina López Santalla, Mercedes García Cuesta, Eva María Rodríguez Frade, José Miguel Leceta Martínez, Javier Lucas, Pilar Pablos Álvarez, José Luis Martínez-A., Carlos Garín, Marina I. Gomáriz, Rosa P. Mellado, Mario 577.17 616.72-002 577.27 Collagen-induced arthritis Growth hormone Th17/Th1 cells Cytokines Immune regulation Bioquímica (Medicina) Inmunología Reumatología 2412 Inmunología 3205.09 Reumatología Evidence indicates an intimate connection between the neuroendocrine and the immune systems. A number of in vitro and in vivo studies have demonstrated growth hormone (GH) involvement in immune regulation. The GH receptor is expressed by several leukocyte subpopulations, and GH modulates immune cell proliferation and activity. Here, we found that sustained GH expression protected against collagen-induced arthritis (CIA); in GH-transgenic C57BL/6 (GHTg) mice, disease onset was delayed, and its overall severity was decreased. The anti-collagen response was impaired in these mice, as were inflammatory cytokine levels. Compared to control arthritic littermates, immunized GHTg mice showed significantly lower RORγt (retinoic acid receptor-related orphan receptor gamma 2), IL-17, GM-CSF, IL-22, and IFNγ mRNA expression in draining lymph nodes, whereas there were no differences in IL-21, IL-6, or IL-2 mRNA levels. Data thus suggest that Th17/Th1 cell plasticity toward a pathological phenotype is reduced in these mice. Exogenous GH administration in arthritic DBA/1J mice reduced the severity of established CIA as well as the inflammatory environment, which also shows a GH effect on arthritis progression. These results indicate that GH prevents inflammatory joint destruction in CIA. Our findings demonstrate a modulatory GH role in immune system function that contributes to alleviating CIA symptoms and underlines the importance of endocrine regulation of the immune response. Frontiers Media https://hdl.handle.net/20.500.14352/13484 |
| spellingShingle | Inhibitory Role of Growth Hormone in the Induction and Progression Phases of Collagen-Induced Arthritis Villares, Ricardo 577.17 616.72-002 577.27 Collagen-induced arthritis Growth hormone Th17/Th1 cells Cytokines Immune regulation Bioquímica (Medicina) Inmunología Reumatología 2412 Inmunología 3205.09 Reumatología |
| title | Inhibitory Role of Growth Hormone in the Induction and Progression Phases of Collagen-Induced Arthritis |
| title_full | Inhibitory Role of Growth Hormone in the Induction and Progression Phases of Collagen-Induced Arthritis |
| title_fullStr | Inhibitory Role of Growth Hormone in the Induction and Progression Phases of Collagen-Induced Arthritis |
| title_full_unstemmed | Inhibitory Role of Growth Hormone in the Induction and Progression Phases of Collagen-Induced Arthritis |
| title_short | Inhibitory Role of Growth Hormone in the Induction and Progression Phases of Collagen-Induced Arthritis |
| title_sort | Inhibitory Role of Growth Hormone in the Induction and Progression Phases of Collagen-Induced Arthritis |
| topic | 577.17 616.72-002 577.27 Collagen-induced arthritis Growth hormone Th17/Th1 cells Cytokines Immune regulation Bioquímica (Medicina) Inmunología Reumatología 2412 Inmunología 3205.09 Reumatología |
| topic_facet | 577.17 616.72-002 577.27 Collagen-induced arthritis Growth hormone Th17/Th1 cells Cytokines Immune regulation Bioquímica (Medicina) Inmunología Reumatología 2412 Inmunología 3205.09 Reumatología |
| url | https://hdl.handle.net/20.500.14352/13484 |