Palladium-Catalyzed Formal (5 + 2) Annulation between ortho-Alkenylanilides and Allenes
2-Alkenyltriflylanilides react with allenes upon treatment with catalytic amounts of Pd(OAc)2 and Cu(II) to give highly valuable 2,3-dihydro-1H-benzo[b]azepines, in good yields, and with very high regio- and diastereoselectivities. Density functional theory (DFT) calculations suggest that the C–H ac...
| Autores: | ; ; ; ; ; ; |
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| Tipo de documento: | Artículo |
| Fecha de publicación: | 2017 |
| País: | España |
| Institución: | Universidad de Santiago de Compostela (USC) |
| Repositorio: | Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela |
| Lenguaje: | Inglés |
| OAI Identifier: | oai:minerva.usc.gal:10347/15444 |
| Acceso en línea: | http://hdl.handle.net/10347/15444 |
| Nivel de acceso: | Acceso abierto |
| Palabra clave: | Materias::Investigación::23 Química::2302 Bioquímica |
| Sumario: | 2-Alkenyltriflylanilides react with allenes upon treatment with catalytic amounts of Pd(OAc)2 and Cu(II) to give highly valuable 2,3-dihydro-1H-benzo[b]azepines, in good yields, and with very high regio- and diastereoselectivities. Density functional theory (DFT) calculations suggest that the C–H activation of the alkenylanilide involves a classical concerted metalation–deprotonation (CMD) mechanism |
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