Parkinson's disease is a neurodegenerative movement disorder that currently has no disease-modifying treatment, partly owing to inefficiencies in drug target identification and validation. We use Mendelian randomization to investigate over 3,000 genes that encode druggable proteins and predict their...
Bibliographic Details
| Authors: |
Storm, Catherine|||0000-0003-4957-1712;
Kia, Demis A.;
Almramhi, Mona M.;
Bandres-Ciga, Sara|||0000-0003-0056-1361;
Finan, Chris|||0000-0002-3319-1937;
Noyce, Alastair J.;
Kaiyrzhanov, Rauan|||0000-0003-1640-4010;
Middlehurst, Ben;
Tan, Manuela|||0000-0001-5835-669X;
Houlden, Henry|||0000-0002-2866-7777;
Morris, Huw|||0000-0002-5473-3774;
Plun-Favreau, Helene;
Holmans, Peter|||0000-0003-0870-9412;
Hardy, John|||0000-0002-3122-0423;
Trabzuni, Daniah|||0000-0003-4826-9570;
Quinn, John;
Bubb, Vivien;
Mok, Kin Y.;
Kinghorn, Kerri J.|||0000-0003-2048-4332;
Lewis, Patrick|||0000-0003-4537-0489;
Schreglmann, Sebastian R.;
Lovering, Ruth;
R'Bibo, Lea;
Manzoni, Claudia|||0000-0001-5367-4023;
Rizig, Mie|||0000-0003-2420-4449;
Ryten, Mina;
Guelfi, Sebastian;
Escott-Price, Valentina|||0000-0003-1784-5483;
Chelban, Viorica|||0000-0002-5817-6290;
Foltynie, Thomas|||0000-0003-0752-1813;
Williams, Nigel;
Morrison, Karen E.|||0000-0003-0216-5717;
Clarke, Car;
Harvey, Kirsten;
Jacobs, Benjamin M.;
Brice, Alexis|||0000-0002-0941-3990;
Danjou, Fabrice|||0000-0002-4976-2327;
Lesage, Suzanne;
Corvol, Jean-Christophe|||0000-0001-7325-0199;
Martinez, Maria;
Schulte, Claudia|||0000-0003-4006-1265;
Brockmann, Kathrin|||0000-0002-7515-8596;
Simón-Sánchez, Javier;
Heutink, Peter|||0000-0001-5218-1737;
Rizzu, Patrizia;
Sharma, Manu;
Gasser, Thomas|||0000-0003-4882-2647;
Schneider, Susanne A.;
Cookson, Mark R.;
Blauwendraat, Cornelis|||0000-0001-9358-8111;
Craig, David W.|||0000-0003-2040-1955;
Billingsley, Kimberley;
Makarious, Mary B.;
Narendra, Derek P.;
Faghri, Faraz;
Gibbs, J. Raphael|||0000-0002-6985-0658;
Hernández, Dena G.;
Van Keuren-Jensen, K.;
Shulman, Joshua M.;
Iwaki, Hirotaka;
Leonard, Hampton L.|||0000-0003-2390-8110;
Nalls, Mike A.;
Robak, Laurie;
Bras, Jose|||0000-0001-8186-0333;
Guerreiro, Rita|||0000-0001-5879-3486;
Lubbe, Steven;
Troycoco, Timothy;
Finkbeiner, Steven;
Mencacci, Niccolo E.;
Lungu, Codrin;
Singleton, Andrew B.|||0000-0001-5606-700X;
Scholz, Sonja|||0000-0002-6623-0429;
Reed, Xylena;
Uitti, Ryan J.;
Ross, Owen A.|||0000-0003-4813-756X;
Grenn, Francis P.;
Moore, Anni;
Alcalay, Roy N.;
Wszolek, Zbigniew K.|||0000-0001-5487-1053;
Gan-Or, Ziv|||0000-0003-0332-234X;
Rouleau, Guy A.|||0000-0001-8403-1418;
Krohn, Lynne|||0000-0001-6554-1666;
Mufti, Kheireddin;
van Hilten, Jacobus J.;
Marinus, Johan;
Adarmes-Gómez, A.D.|||0000-0002-1337-9289;
Aguilar Barberà, Miquel;
Alvarez, Ignacio|||0000-0002-8537-3935;
Alvarez, Victoria|||0000-0002-1916-2523;
Barrero, Francisco Javier;
Yarza, Jesús Alberto Bergareche;
Bernal-Bernal, Inmaculada;
Blázquez Estrada, Marta|||0000-0003-3348-9992;
Bonilla-Toribio, Marta;
Botía, Juan A.|||0000-0002-6992-598X;
Boungiorno, María Teresa;
Buiza-Rueda, Dolores|||0000-0002-3504-9299;
Cámara, Ana|||0000-0002-8005-9461;
Carrillo, Fátima;
Carrión-Claro, M.;
Cerdan, Debora|||0000-0001-5408-691X;
Clarimón, Jordi|||0000-0002-6824-6942;
Compta, Yaroslau|||0000-0001-6443-0104;
Diez-Fairen, Monica|||0000-0003-1882-0309;
Dols Icardo, Oriol|||0000-0003-2656-8748;
Duarte, Jacinto;
Duran, Raquel;
Escamilla Sevilla, Francisco|||0000-0003-2149-2668;
Ezquerra, Mario|||0000-0003-3246-6641;
Feliz, Cici;
Fernández, Manel;
Fernández-Santiago, Rubén|||0000-0002-4582-0702;
Garcia, Ciara;
García-Ruiz, Pedro;
Gómez-Garre, Pilar|||0000-0002-0437-6182;
Gomez Heredia, Maria Jose;
Gonzalez-Aramburu, Isabel|||0000-0002-3696-4093;
Gorostidi Pagola, Ana;
Hoenicka, Janet|||0000-0002-6790-6988;
Infante, Jon|||0000-0003-4025-4606;
Jesús, Silvia;
Jiménez-Escrig, Adriano|||0000-0002-4927-1886;
Kulisevsky, Jaime|||0000-0003-4870-1431;
Labrador-Espinosa, Miguel A.|||0000-0003-3576-1777;
López-Sendon, Jose Luis;
López de Munain Arregui, Adolfo;
Macías-García, Daniel|||0000-0002-4822-1529;
Martínez Torres, Irene;
Marín, Juan;
Marti, María José;
Martínez-Castrillo, Juan Carlos|||0000-0001-7744-6850;
Méndez-del-Barrio, Carlota;
Menéndez González, Manuel;
Mata, Marina|||0000-0001-9693-7663;
Mínguez, Adolfo M.;
Mir, Pablo|||0000-0003-1656-302X;
Mondragon Rezola, Elisabet;
Muñoz, Esteban;
Pagonabarraga Mora, Javier|||0000-0002-3248-704X;
Pastor, Pau|||0000-0002-7493-8777;
Perez-Errazquin, Francisco;
Periñán-Tocino, Teresa;
Ruiz-Martínez, Javier;
Ruz, Clara;
Sánchez Rodríguez, Antonio;
Sierra, Maria;
Suarez-Sanmartin, Esther;
Tabernero, Cesar;
Tartari, Juan Pablo;
Tejera-Parrado, Cristina|||0000-0001-8001-5621;
Tolosa, Eduard|||0000-0001-6608-3038;
Valldeoriola, Francesc|||0000-0002-8680-4274;
Vargas-González, Laura;
Vela, Lydia|||0000-0001-6663-395X;
Vives, Francisco;
Zimprich, Alexander|||0000-0002-1668-5177;
Pihlstrom, Lasse;
Toft, Mathias|||0000-0002-6723-6865;
Taba, Pille|||0000-0002-1315-1065;
Koks, Sulev;
Hassin-Baer, Sharon;
Majamaa, Kari|||0000-0002-9070-3791;
Siitonen, Ari;
Tienari, Pentti;
Okubadejo, Njideka U.;
Ojo, Oluwadamilola O.;
Shashkin, Chingiz;
Zharkinbekova, Nazira;
Akhmetzhanov, Vadim;
Kaishybayeva, Gulnaz;
Karimova, Altynay;
Khaibullin, Talgat;
Lynch, Timothy L.;
Hingorani, Aroon|||0000-0001-8365-0081;
Wood, Nicholas W.|||0000-0002-9500-3348 |
|---|
| Format: | Article
|
|---|
| Publication date: | 2021 |
|---|
| Country: | España |
|---|
| Institution: | Universitat Autònoma de Barcelona |
|---|
| Repository: | Dipòsit Digital de Documents de la UAB |
|---|
| Language: | English |
|---|
| OAI Identifier: | oai:ddd.uab.cat:264453 |
|---|
| Online Access: | https://ddd.uab.cat/record/264453
https://dx.doi.org/urn:doi:10.1038/s41467-021-26280-1
|
|---|
| Access Level: | Open access |
|---|
| Keyword: | Brain
Case-Control Studies
Cohort Studies
Disease Progression
Gene Expression Regulation
Genetic Predisposition to Disease
Genetic Variation
Genome, Human
Humans
Mendelian Randomization Analysis
Parkinson Disease
Quantitative Trait Loci
Risk Factors |
|---|