BDNF Val66Met gene polymorphism modulates brain activity following rTMS-induced memory impairment
The BDNF Val66Met gene polymorphism is a relevant factor explaining inter-individual differences to TMS responses in studies of the motor system. However, whether this variant also contributes to TMS-induced memory effects, as well as their underlying brain mechanisms, remains unexplored. In this in...
| Autores: | ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; |
|---|---|
| Tipo de documento: | Artigo |
| Data de publicação: | 2022 |
| País: | España |
| Recursos: | Universitat Autònoma de Barcelona |
| Repositório: | Dipòsit Digital de Documents de la UAB |
| Idioma: | Inglês |
| OAI Identifier: | oai:ddd.uab.cat:252164 |
| Acesso em linha: | https://ddd.uab.cat/record/252164 https://dx.doi.org/urn:doi:10.1038/s41598-021-04175-x |
| Nível de acesso: | Acesso aberto |
| Palavra-chave: | Neuroscience Cognitive neuroscience Psychology Human behaviour |
| _version_ | 1878737352851980288 |
|---|---|
| author | Abellaneda Pérez, Kilian|||0000-0001-6447-1248 |
| author2 | Martin-Trias, Pablo Cassé-Perrot, Catherine Vaqué-Alcázar, Lídia|||0000-0002-6776-6559 Lanteaume, Laura Solana, Elisabeth|||0000-0001-7973-2439 Babiloni, Claudio|||0000-0002-5245-9839 Lizio, Roberta|||0000-0003-1262-3689 Junqué, Carme|||0000-0002-6381-3063 Bargalló, Núria|||0000-0001-6284-5402 Rossini, Paolo Maria Micallef, Joëlle Truillet, Romain Charles, Estelle Jouve, Elisabeth|||0000-0002-4873-6522 Bordet, Régis|||0000-0003-3916-6422 Santamaria, Joan Rossi, Simone|||0000-0001-6697-9459 Pascual Leone, Álvaro|||0000-0001-8975-0382 Blin, Olivier Richardson, Jill|||0000-0001-6564-3187 Jovicich, Jorge|||0000-0001-9504-7503 Bartrés-Faz, David|||0000-0001-6020-4118 |
| author2_role | author author author author author author author author author author author author author author author author author author author author author author |
| author_browse | Abellaneda Pérez, Kilian|||0000-0001-6447-1248 Babiloni, Claudio|||0000-0002-5245-9839 Bargalló, Núria|||0000-0001-6284-5402 Bartrés-Faz, David|||0000-0001-6020-4118 Blin, Olivier Bordet, Régis|||0000-0003-3916-6422 Cassé-Perrot, Catherine Charles, Estelle Jouve, Elisabeth|||0000-0002-4873-6522 Jovicich, Jorge|||0000-0001-9504-7503 Junqué, Carme|||0000-0002-6381-3063 Lanteaume, Laura Lizio, Roberta|||0000-0003-1262-3689 Martin-Trias, Pablo Micallef, Joëlle Pascual Leone, Álvaro|||0000-0001-8975-0382 Richardson, Jill|||0000-0001-6564-3187 Rossi, Simone|||0000-0001-6697-9459 Rossini, Paolo Maria Santamaria, Joan Solana, Elisabeth|||0000-0001-7973-2439 Truillet, Romain Vaqué-Alcázar, Lídia|||0000-0002-6776-6559 |
| author_facet | Abellaneda Pérez, Kilian|||0000-0001-6447-1248 Martin-Trias, Pablo Cassé-Perrot, Catherine Vaqué-Alcázar, Lídia|||0000-0002-6776-6559 Lanteaume, Laura Solana, Elisabeth|||0000-0001-7973-2439 Babiloni, Claudio|||0000-0002-5245-9839 Lizio, Roberta|||0000-0003-1262-3689 Junqué, Carme|||0000-0002-6381-3063 Bargalló, Núria|||0000-0001-6284-5402 Rossini, Paolo Maria Micallef, Joëlle Truillet, Romain Charles, Estelle Jouve, Elisabeth|||0000-0002-4873-6522 Bordet, Régis|||0000-0003-3916-6422 Santamaria, Joan Rossi, Simone|||0000-0001-6697-9459 Pascual Leone, Álvaro|||0000-0001-8975-0382 Blin, Olivier Richardson, Jill|||0000-0001-6564-3187 Jovicich, Jorge|||0000-0001-9504-7503 Bartrés-Faz, David|||0000-0001-6020-4118 |
| author_role | author |
| collection | Dipòsit Digital de Documents de la UAB |
| description | The BDNF Val66Met gene polymorphism is a relevant factor explaining inter-individual differences to TMS responses in studies of the motor system. However, whether this variant also contributes to TMS-induced memory effects, as well as their underlying brain mechanisms, remains unexplored. In this investigation, we applied rTMS during encoding of a visual memory task either over the left frontal cortex (LFC; experimental condition) or the cranial vertex (control condition). Subsequently, individuals underwent a recognition memory phase during a functional MRI acquisition. We included 43 young volunteers and classified them as 19 Met allele carriers and 24 as Val/Val individuals. The results revealed that rTMS delivered over LFC compared to vertex stimulation resulted in reduced memory performance only amongst Val/Val allele carriers. This genetic group also exhibited greater fMRI brain activity during memory recognition, mainly over frontal regions, which was positively associated with cognitive performance. We concluded that BDNF Val66Met gene polymorphism, known to exert a significant effect on neuroplasticity, modulates the impact of rTMS both at the cognitive as well as at the associated brain networks expression levels. This data provides new insights on the brain mechanisms explaining cognitive inter-individual differences to TMS, and may inform future, more individually-tailored rTMS interventions. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_9e794d7434a648e8a82e2dbe3b1e257b |
| institution | Universitat Autònoma de Barcelona |
| instname_str | Universitat Autònoma de Barcelona |
| language | eng |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:ddd.uab.cat:252164 |
| publishDate | 2022 |
| publishDateSort | 2022 |
| reponame_str | Dipòsit Digital de Documents de la UAB |
| spelling | BDNF Val66Met gene polymorphism modulates brain activity following rTMS-induced memory impairment Abellaneda Pérez, Kilian|||0000-0001-6447-1248 Martin-Trias, Pablo Cassé-Perrot, Catherine Vaqué-Alcázar, Lídia|||0000-0002-6776-6559 Lanteaume, Laura Solana, Elisabeth|||0000-0001-7973-2439 Babiloni, Claudio|||0000-0002-5245-9839 Lizio, Roberta|||0000-0003-1262-3689 Junqué, Carme|||0000-0002-6381-3063 Bargalló, Núria|||0000-0001-6284-5402 Rossini, Paolo Maria Micallef, Joëlle Truillet, Romain Charles, Estelle Jouve, Elisabeth|||0000-0002-4873-6522 Bordet, Régis|||0000-0003-3916-6422 Santamaria, Joan Rossi, Simone|||0000-0001-6697-9459 Pascual Leone, Álvaro|||0000-0001-8975-0382 Blin, Olivier Richardson, Jill|||0000-0001-6564-3187 Jovicich, Jorge|||0000-0001-9504-7503 Bartrés-Faz, David|||0000-0001-6020-4118 Neuroscience Cognitive neuroscience Psychology Human behaviour The BDNF Val66Met gene polymorphism is a relevant factor explaining inter-individual differences to TMS responses in studies of the motor system. However, whether this variant also contributes to TMS-induced memory effects, as well as their underlying brain mechanisms, remains unexplored. In this investigation, we applied rTMS during encoding of a visual memory task either over the left frontal cortex (LFC; experimental condition) or the cranial vertex (control condition). Subsequently, individuals underwent a recognition memory phase during a functional MRI acquisition. We included 43 young volunteers and classified them as 19 Met allele carriers and 24 as Val/Val individuals. The results revealed that rTMS delivered over LFC compared to vertex stimulation resulted in reduced memory performance only amongst Val/Val allele carriers. This genetic group also exhibited greater fMRI brain activity during memory recognition, mainly over frontal regions, which was positively associated with cognitive performance. We concluded that BDNF Val66Met gene polymorphism, known to exert a significant effect on neuroplasticity, modulates the impact of rTMS both at the cognitive as well as at the associated brain networks expression levels. This data provides new insights on the brain mechanisms explaining cognitive inter-individual differences to TMS, and may inform future, more individually-tailored rTMS interventions. https://ddd.uab.cat/record/252164 https://dx.doi.org/urn:doi:10.1038/s41598-021-04175-x |
| spellingShingle | BDNF Val66Met gene polymorphism modulates brain activity following rTMS-induced memory impairment Abellaneda Pérez, Kilian|||0000-0001-6447-1248 Neuroscience Cognitive neuroscience Psychology Human behaviour |
| title | BDNF Val66Met gene polymorphism modulates brain activity following rTMS-induced memory impairment |
| title_full | BDNF Val66Met gene polymorphism modulates brain activity following rTMS-induced memory impairment |
| title_fullStr | BDNF Val66Met gene polymorphism modulates brain activity following rTMS-induced memory impairment |
| title_full_unstemmed | BDNF Val66Met gene polymorphism modulates brain activity following rTMS-induced memory impairment |
| title_short | BDNF Val66Met gene polymorphism modulates brain activity following rTMS-induced memory impairment |
| title_sort | BDNF Val66Met gene polymorphism modulates brain activity following rTMS-induced memory impairment |
| topic | Neuroscience Cognitive neuroscience Psychology Human behaviour |
| topic_facet | Neuroscience Cognitive neuroscience Psychology Human behaviour |
| url | https://ddd.uab.cat/record/252164 https://dx.doi.org/urn:doi:10.1038/s41598-021-04175-x |