Unraveling the role of resistin, retinol-binding protein 4 and adiponectin produced by epicardial adipose tissue in cardiac structure and function: evidence of a paracrine effect
PurposeAdipokines produced by adipose tissue have been found to be involved in the pathophysiology of metabolic and cardiovascular diseases. We aimed to investigate the relationships of resistin, retinol-binding protein 4 (RBP4) and adiponectin produced by epicardial adipose tissue with coronary art...
| Authors: | ; ; ; ; ; ; |
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| Format: | Article |
| Publication date: | 2023 |
| Country: | España |
| Institution: | Universidad de Navarra |
| Repository: | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| Language: | English |
| OAI Identifier: | oai:dadun.unav.edu:10171/66524 |
| Online Access: | https://hdl.handle.net/10171/66524 |
| Access Level: | Open access |
| Keyword: | Adipokines Epicardial fat Adipose tissue Left ventricular function Coronary artery disease |
| _version_ | 1878737246921687040 |
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| author | Christou, G. A. (Georgios A.)|||/items/dbf01a72-e54e-4500-b4a2-412cb3183d81 |
| author2 | Andriopoulou, C. E. (Christina E.)|||/items/c6f670fd-79ee-4687-9eb7-36ccedbe526e Liakopoulou, A. (Alexandra)|||/items/75a60eb7-7fc8-4283-90fd-988907aa6c49 Tsape, E. (Eirini)|||/items/cf1795b7-ae7b-41bf-9c94-0176723c2ae7 Konstandi, M. (Maria)|||/items/ddfded8c-2aa6-4c3f-856a-17aa8901ace5 Frühbeck, G. (Gema)|||/items/7f0b1f72-bc91-4ab0-a3fd-21e9a3fb663b Kiortsis, D.N. (Dimitrios N.)|||/items/2ca34bdc-ff78-440b-ad8c-7d846dc438e6 |
| author2_role | author author author author author author |
| author_browse | Andriopoulou, C. E. (Christina E.)|||/items/c6f670fd-79ee-4687-9eb7-36ccedbe526e Christou, G. A. (Georgios A.)|||/items/dbf01a72-e54e-4500-b4a2-412cb3183d81 Frühbeck, G. (Gema)|||/items/7f0b1f72-bc91-4ab0-a3fd-21e9a3fb663b Kiortsis, D.N. (Dimitrios N.)|||/items/2ca34bdc-ff78-440b-ad8c-7d846dc438e6 Konstandi, M. (Maria)|||/items/ddfded8c-2aa6-4c3f-856a-17aa8901ace5 Liakopoulou, A. (Alexandra)|||/items/75a60eb7-7fc8-4283-90fd-988907aa6c49 Tsape, E. (Eirini)|||/items/cf1795b7-ae7b-41bf-9c94-0176723c2ae7 |
| author_facet | Christou, G. A. (Georgios A.)|||/items/dbf01a72-e54e-4500-b4a2-412cb3183d81 Andriopoulou, C. E. (Christina E.)|||/items/c6f670fd-79ee-4687-9eb7-36ccedbe526e Liakopoulou, A. (Alexandra)|||/items/75a60eb7-7fc8-4283-90fd-988907aa6c49 Tsape, E. (Eirini)|||/items/cf1795b7-ae7b-41bf-9c94-0176723c2ae7 Konstandi, M. (Maria)|||/items/ddfded8c-2aa6-4c3f-856a-17aa8901ace5 Frühbeck, G. (Gema)|||/items/7f0b1f72-bc91-4ab0-a3fd-21e9a3fb663b Kiortsis, D.N. (Dimitrios N.)|||/items/2ca34bdc-ff78-440b-ad8c-7d846dc438e6 |
| author_role | author |
| collection | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| description | PurposeAdipokines produced by adipose tissue have been found to be involved in the pathophysiology of metabolic and cardiovascular diseases. We aimed to investigate the relationships of resistin, retinol-binding protein 4 (RBP4) and adiponectin produced by epicardial adipose tissue with coronary artery disease (CAD) and cardiac structure and function.MethodsForty-one non-diabetic males scheduled for cardiothoracic surgery were examined. Anthropometric measurements, echocardiography, coronary angiography, and blood analysis were performed preoperatively. We measured the serum levels of resistin, RBP4, and adiponectin and their mRNA expression in thoracic subcutaneous adipose tissue and two epicardial adipose tissue samples, one close to left anterior descending artery (LAD) (resistin-LAD, RBP4-LAD, adiponectin-LAD), and another close to the right coronary artery (RCA) (resistin-RCA, RBP4-RCA, adiponectin-RCA).ResultsLeft ventricular (LV) ejection fraction correlated negatively with adiponectin-LAD (rho = - 0.390, p = 0.025). The ratio of early to late diastolic transmitral flow velocity, as an index of LV diastolic function, correlated negatively with resistin-LAD (rho = - 0.529, p = 0.024) and RBP4-LAD (rho = - 0.458, p = 0.049). There was no difference in epicardial adipose tissue mRNA expression of resistin, RBP4, and adiponectin between individuals with CAD and those without CAD. When we compared the individuals with CAD in the LAD with those without CAD in the LAD, there was no difference in resistin-LAD, RBP4-LAD, and adiponectin-LAD. There was no difference in resistin-RCA, RBP4-RCA, and adiponectin-RCA between the individuals with CAD in the RCA and those without CAD in the RCA.ConclusionElevation of epicardial adipose tissue mRNA expression of adiponectin was associated with LV systolic dysfunction, while that of both resistin and RBP4 was linked to LV diastolic dysfunction. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_9ce2f458bead79ce99bdeb9543fef65f |
| institution | Universidad de Navarra |
| instname_str | Universidad de Navarra |
| language | eng |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:dadun.unav.edu:10171/66524 |
| publishDate | 2023 |
| publishDateSort | 2023 |
| reponame_str | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| spelling | Unraveling the role of resistin, retinol-binding protein 4 and adiponectin produced by epicardial adipose tissue in cardiac structure and function: evidence of a paracrine effect Christou, G. A. (Georgios A.)|||/items/dbf01a72-e54e-4500-b4a2-412cb3183d81 Andriopoulou, C. E. (Christina E.)|||/items/c6f670fd-79ee-4687-9eb7-36ccedbe526e Liakopoulou, A. (Alexandra)|||/items/75a60eb7-7fc8-4283-90fd-988907aa6c49 Tsape, E. (Eirini)|||/items/cf1795b7-ae7b-41bf-9c94-0176723c2ae7 Konstandi, M. (Maria)|||/items/ddfded8c-2aa6-4c3f-856a-17aa8901ace5 Frühbeck, G. (Gema)|||/items/7f0b1f72-bc91-4ab0-a3fd-21e9a3fb663b Kiortsis, D.N. (Dimitrios N.)|||/items/2ca34bdc-ff78-440b-ad8c-7d846dc438e6 Adipokines Epicardial fat Adipose tissue Left ventricular function Coronary artery disease PurposeAdipokines produced by adipose tissue have been found to be involved in the pathophysiology of metabolic and cardiovascular diseases. We aimed to investigate the relationships of resistin, retinol-binding protein 4 (RBP4) and adiponectin produced by epicardial adipose tissue with coronary artery disease (CAD) and cardiac structure and function.MethodsForty-one non-diabetic males scheduled for cardiothoracic surgery were examined. Anthropometric measurements, echocardiography, coronary angiography, and blood analysis were performed preoperatively. We measured the serum levels of resistin, RBP4, and adiponectin and their mRNA expression in thoracic subcutaneous adipose tissue and two epicardial adipose tissue samples, one close to left anterior descending artery (LAD) (resistin-LAD, RBP4-LAD, adiponectin-LAD), and another close to the right coronary artery (RCA) (resistin-RCA, RBP4-RCA, adiponectin-RCA).ResultsLeft ventricular (LV) ejection fraction correlated negatively with adiponectin-LAD (rho = - 0.390, p = 0.025). The ratio of early to late diastolic transmitral flow velocity, as an index of LV diastolic function, correlated negatively with resistin-LAD (rho = - 0.529, p = 0.024) and RBP4-LAD (rho = - 0.458, p = 0.049). There was no difference in epicardial adipose tissue mRNA expression of resistin, RBP4, and adiponectin between individuals with CAD and those without CAD. When we compared the individuals with CAD in the LAD with those without CAD in the LAD, there was no difference in resistin-LAD, RBP4-LAD, and adiponectin-LAD. There was no difference in resistin-RCA, RBP4-RCA, and adiponectin-RCA between the individuals with CAD in the RCA and those without CAD in the RCA.ConclusionElevation of epicardial adipose tissue mRNA expression of adiponectin was associated with LV systolic dysfunction, while that of both resistin and RBP4 was linked to LV diastolic dysfunction. https://hdl.handle.net/10171/66524 |
| spellingShingle | Unraveling the role of resistin, retinol-binding protein 4 and adiponectin produced by epicardial adipose tissue in cardiac structure and function: evidence of a paracrine effect Christou, G. A. (Georgios A.)|||/items/dbf01a72-e54e-4500-b4a2-412cb3183d81 Adipokines Epicardial fat Adipose tissue Left ventricular function Coronary artery disease |
| title | Unraveling the role of resistin, retinol-binding protein 4 and adiponectin produced by epicardial adipose tissue in cardiac structure and function: evidence of a paracrine effect |
| title_full | Unraveling the role of resistin, retinol-binding protein 4 and adiponectin produced by epicardial adipose tissue in cardiac structure and function: evidence of a paracrine effect |
| title_fullStr | Unraveling the role of resistin, retinol-binding protein 4 and adiponectin produced by epicardial adipose tissue in cardiac structure and function: evidence of a paracrine effect |
| title_full_unstemmed | Unraveling the role of resistin, retinol-binding protein 4 and adiponectin produced by epicardial adipose tissue in cardiac structure and function: evidence of a paracrine effect |
| title_short | Unraveling the role of resistin, retinol-binding protein 4 and adiponectin produced by epicardial adipose tissue in cardiac structure and function: evidence of a paracrine effect |
| title_sort | Unraveling the role of resistin, retinol-binding protein 4 and adiponectin produced by epicardial adipose tissue in cardiac structure and function: evidence of a paracrine effect |
| topic | Adipokines Epicardial fat Adipose tissue Left ventricular function Coronary artery disease |
| topic_facet | Adipokines Epicardial fat Adipose tissue Left ventricular function Coronary artery disease |
| url | https://hdl.handle.net/10171/66524 |