Inflammation in metabolically healthy and metabolically abnormal adolescents: The HELENA study

Background and aims Inflammation may influence the cardio-metabolic profile which relates with the risk of chronic diseases. This study aimed to assess the inflammatory status by metabolic health (MH)/body mass index (BMI) category and to assess how inflammatory markers can predict the cardio-metabo...

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Authors: González-Gil, E.M.; Cadenas-Sanchez, C.; Santabárbara, J.; Bueno-Lozano, G.; Iglesia, I.; González-Gross, M.; Molnar, D.; Gottrand, F.; De Henauw, S.; Kafatos, A.; Widhalm, K.; Manios, Y.; Siani, A.; Amaro-Gahete, F.; Rupérez A.I.; Cañada, D.; Censi, L.; Kersting, M.; Dallongeville, J.; Marcos, A.; Ortega, F.B.; Moreno, L.A.; Gilbert, C.; Libersa, C.; Castelló, S.; Sjöstrom, M.; Molnár, D.; Hall, G.; Maes, L.; Scalfi, L.; Meléndez, P.; Fleta, J.; Casajús, J.A.; Rodríguez, G.; Tomás, C.; Mesana, M.I.; Vicente-Rodríguez, G.; Villarroya, A.; Gil, C.M.; Ara, I.; Alvira, J.F.; Bueno, G.; Lázaro, A.; Bueno, O.; León, J.F.; Garagorri, J.M.; Bueno, M.; Labayen, I.; Bel Serrat, S.; Gracia Marco, L.A.; Mouratidou, T.; Santaliestra-Pasías, A.; De Miguel-Etayo, P.; Julián Almárcegui, C.; Miguel-Berges, M.; Iguacel, I.; Wärnberg, J.; Nova, E.; Gómez, S.; Díaz, L.E.; Romeo, J.; Veses, A.; Zapatera, B.; Pozo, T.; Martínez, D.; Beghin, L.; Iliescu, C.; Von Berlepsch, J.; Sichert-Hellert, W.; Koeppen, E.; Erhardt, E.; Csernus, K.; Török, K.; Bokor, S.; Angster; Nagy, E.; Kovács, O.; Répasi, J.; Codrington, C.; Plada, M.; Papadaki, A.; Sarri, K.; Viskadourou, A.; Hatzis, C.; Kiriakakis, M.; Tsibinos, G.; Vardavas, C.; Sbokos, M.; Protoyeraki, E.; Fasoulaki, M.; Stehle, P.; Pietrzik, K.; Breidenassel, C.; Spinneker, A.; Al-Tahan, J.; Segoviano, M.; Berchtold, A.; Bierschbach, C.; Blatzheim, E.; Schuch, A.; Pickert, P.; Castillo, M.J.; Gutiérrez, Á.; Ruiz, J.R.; Artero, E.G.; España, V.; Jiménez-Pavón, D.; Chillón, P.; Sánchez-Muñoz, C.; Cuenca, M.; Arcella, D.; Azzini, E.; Barrison, E.; Bevilacqua, N.; Buonocore, P.; Catasta, G.; Ciarapica, D.; D''Acapito, P.; Ferrari, M.; Galfo, M.; Le Donne, C.; Leclercq, C.; Maiani, G.; Mauro, B.; Mistura, L.; Pasquali, A.; Piccinelli, R.; Polito, A.; Roccaldo, R.; Spada, R.; Sette, S.; Zaccaria, M.; Vitaglione, P.; Montagnese, C.; De Bourdeaudhuij, I.; De Vriendt, T.; Matthys, C.; Vereecken, C.; de Maeyer, M.; Ottevaere, C.; Huybrechts, I.; Phillipp, K.; Dietrich, S.; Grammatikaki, E.; Bouloubasi, Z.; Cook, T.L.; Eleutheriou, S.; Consta, O.; Moschonis, G.; Katsaroli, I.; Kraniou, G.; Papoutsou, S.; Keke, D.; Petraki, I.; Bellou, E.; Tanagra, S.; Kallianoti, K.; Argyropoulou, D.; Tsikrika, S.; Karaiskos, C.; Meirhaeghe, A.; Hagströmer, M.; Wennlöf, A.H.; Hallström, L.; Patterson, E.; Kwak, L.; Rizzo, N.; Sánchez-Molero, J.; Picó, E.; Navarro, M.; Viadel, B.; Carreres, J.E.; Merino, G.; Sanjuán, R.; Lorente, M.; Sánchez, M.J.; Thomas, S.; Allchurch, E.; Burgess, P.; Astrom, A.; Sverkén, A.; Broberg, A.; Masson, A.; Lehoux, C.; Brabant, P.; Pate, P.; Fontaine, L.; Sebok, A.; Kuti, T.; Hegyi, A.; Maldonado, C.
Format: Article
Status:Accepted version
Publication date:2018
Country:España
Institution:Universidad de Zaragoza
Repository:Zaguán. Repositorio Digital de la Universidad de Zaragoza
OAI Identifier:oai:zaguan.unizar.es:65584
Online Access:http://zaguan.unizar.es/record/65584
Access Level:Open access
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Summary:Background and aims Inflammation may influence the cardio-metabolic profile which relates with the risk of chronic diseases. This study aimed to assess the inflammatory status by metabolic health (MH)/body mass index (BMI) category and to assess how inflammatory markers can predict the cardio-metabolic profile in European adolescents, considering BMI. Methods and results A total of 659 adolescents (295 boys) from a cross-sectional European study were included. Adolescents were classified by metabolic health based on age- and sex-specific cut-off points for glucose, blood pressure, triglycerides, high density cholesterol and BMI. C-reactive protein (CRP), tumor necrosis factor alpha (TNF-a), interleukin (IL-6), complement factors (C3, C4) and cell adhesion molecules were assessed. Results Metabolically abnormal (MA) adolescents had higher values of C3 (p < 0.001) and C4 (p = 0.032) compared to those metabolically healthy (MHy). C3 concentrations significantly increased with the deterioration of the metabolic health and BMI (p < 0.001). Adolescents with higher values of CRP had higher probability of being in the overweight/obese-MH group than those allocated in other categories. Finally, high C3 and C4 concentrations increased the probability of having an unfavorable metabolic/BMI status. Conclusions Metabolic/BMI status and inflammatory biomarkers are associated, being the CRP, C3 and C4 the most related inflammatory markers with this condition. C3 and C4 were associated with the cardio-metabolic health consistently.