Prognostic factors for survival in patients with metastatic lung adenocarcinoma: An analysis of the SEER database
Background: Lung adenocarcinoma (ADC) is the main cause of death related to lung cancer. The aim of this study was to identify poor prognostic factors for overall survival (OS) in patients with stage IV lung ADC in real-world clinical practice. Methods: Patients were selected from the Surveillance E...
| Autores: | ; ; ; ; ; ; ; |
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| Tipo de documento: | Artículo |
| Fecha de publicación: | 2020 |
| País: | España |
| Institución: | Instituto de Salud Carlos III (ISCIII) |
| Repositorio: | Repisalud |
| Lenguaje: | Inglés |
| OAI Identifier: | oai:repisalud.isciii.es:20.500.12105/17983 |
| Acceso en línea: | http://hdl.handle.net/20.500.12105/17983 |
| Nivel de acceso: | Acceso abierto |
| Palabra clave: | Lung adenocarcinoma Metastasis Non-small cell lung cancer Overall survival Prognostic factor Adenocarcinoma del pulmón Metástasis neoplásica Carcinoma de pulmón de células no pequeñas Pronóstico Lung Aged Female Humans Male Neoplasm Metastasis Prognosis SEER Program Adenocarcinoma Lung Neoplasms Liver Neoplasms |
| _version_ | 1878736989948215296 |
|---|---|
| author | Campos-Balea, Begoña |
| author2 | de Castro Carpeño, Javier Massutí, Bartomeu Vicente-Baz, David Pérez Parente, Diego Ruiz-Gracia, Pedro Crama, Leonardo Cobo Dols, Manuel |
| author2_role | author author author author author author author |
| author_browse | Campos-Balea, Begoña Cobo Dols, Manuel Crama, Leonardo Massutí, Bartomeu Pérez Parente, Diego Ruiz-Gracia, Pedro Vicente-Baz, David de Castro Carpeño, Javier |
| author_facet | Campos-Balea, Begoña de Castro Carpeño, Javier Massutí, Bartomeu Vicente-Baz, David Pérez Parente, Diego Ruiz-Gracia, Pedro Crama, Leonardo Cobo Dols, Manuel |
| author_role | author |
| collection | Repisalud |
| description | Background: Lung adenocarcinoma (ADC) is the main cause of death related to lung cancer. The aim of this study was to identify poor prognostic factors for overall survival (OS) in patients with stage IV lung ADC in real-world clinical practice. Methods: Patients were selected from the Surveillance Epidemiology and End Results (SEER) database. Chi-square bivariate analysis was used for the association of binary qualitative variables. A multivariate Cox regression analysis was performed to determine the impact of these prognostic factors on OS. Results: A total of 46 030 patients were included (51.3% men, mean age 67.03 ± 11.6), of whom 41.3% presented with metastases in bone, 28.9% in brain, 17.1% in liver and 31.8% in lung. Patients with liver metastases presented with two or more metastatic sites more frequently than patients without liver metastases (P < 0.001). Male sex (HR 0.78, 95% CI: 0.76-0.80), age ≥ 65 years (HR 1.37, 95% CI: 1.33-1.40), lack of family support (HR 0.80, 95% CI: 0.78-0.81) and presence of liver (HR 1.45, 95% CI: 1.40-1.50), bone (HR 1.21, 95% CI: 1.18-1.24) or brain metastases (HR 1.18, 95% CI: 1.15-1.21) were identified as poor prognostic factors for OS. Patients with liver metastasis showed the highest hazard ratio value (P < 0.001). Conclusions: The presence of liver metastases was the worst prognostic factor for patients with metastatic lung ADC. This factor should be considered as a stratification factor for future studies evaluating new cancer treatments including immunotherapy. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_98a3f1f91e8d9d61bb7a712ae850a19b |
| institution | Instituto de Salud Carlos III (ISCIII) |
| instname_str | Instituto de Salud Carlos III (ISCIII) |
| language | eng |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:repisalud.isciii.es:20.500.12105/17983 |
| publishDate | 2020 |
| publishDateSort | 2020 |
| publisher | China Lung Oncology Group and John Wiley & Sons Australia, Ltd. |
| publisherStr | China Lung Oncology Group and John Wiley & Sons Australia, Ltd. |
| reponame_str | Repisalud |
| spelling | Prognostic factors for survival in patients with metastatic lung adenocarcinoma: An analysis of the SEER database Campos-Balea, Begoña de Castro Carpeño, Javier Massutí, Bartomeu Vicente-Baz, David Pérez Parente, Diego Ruiz-Gracia, Pedro Crama, Leonardo Cobo Dols, Manuel Lung adenocarcinoma Metastasis Non-small cell lung cancer Overall survival Prognostic factor Adenocarcinoma del pulmón Metástasis neoplásica Carcinoma de pulmón de células no pequeñas Pronóstico Lung Aged Female Humans Male Neoplasm Metastasis Prognosis SEER Program Adenocarcinoma Lung Neoplasms Liver Neoplasms Background: Lung adenocarcinoma (ADC) is the main cause of death related to lung cancer. The aim of this study was to identify poor prognostic factors for overall survival (OS) in patients with stage IV lung ADC in real-world clinical practice. Methods: Patients were selected from the Surveillance Epidemiology and End Results (SEER) database. Chi-square bivariate analysis was used for the association of binary qualitative variables. A multivariate Cox regression analysis was performed to determine the impact of these prognostic factors on OS. Results: A total of 46 030 patients were included (51.3% men, mean age 67.03 ± 11.6), of whom 41.3% presented with metastases in bone, 28.9% in brain, 17.1% in liver and 31.8% in lung. Patients with liver metastases presented with two or more metastatic sites more frequently than patients without liver metastases (P < 0.001). Male sex (HR 0.78, 95% CI: 0.76-0.80), age ≥ 65 years (HR 1.37, 95% CI: 1.33-1.40), lack of family support (HR 0.80, 95% CI: 0.78-0.81) and presence of liver (HR 1.45, 95% CI: 1.40-1.50), bone (HR 1.21, 95% CI: 1.18-1.24) or brain metastases (HR 1.18, 95% CI: 1.15-1.21) were identified as poor prognostic factors for OS. Patients with liver metastasis showed the highest hazard ratio value (P < 0.001). Conclusions: The presence of liver metastases was the worst prognostic factor for patients with metastatic lung ADC. This factor should be considered as a stratification factor for future studies evaluating new cancer treatments including immunotherapy. China Lung Oncology Group and John Wiley & Sons Australia, Ltd. http://hdl.handle.net/20.500.12105/17983 |
| spellingShingle | Prognostic factors for survival in patients with metastatic lung adenocarcinoma: An analysis of the SEER database Campos-Balea, Begoña Lung adenocarcinoma Metastasis Non-small cell lung cancer Overall survival Prognostic factor Adenocarcinoma del pulmón Metástasis neoplásica Carcinoma de pulmón de células no pequeñas Pronóstico Lung Aged Female Humans Male Neoplasm Metastasis Prognosis SEER Program Adenocarcinoma Lung Neoplasms Liver Neoplasms |
| title | Prognostic factors for survival in patients with metastatic lung adenocarcinoma: An analysis of the SEER database |
| title_full | Prognostic factors for survival in patients with metastatic lung adenocarcinoma: An analysis of the SEER database |
| title_fullStr | Prognostic factors for survival in patients with metastatic lung adenocarcinoma: An analysis of the SEER database |
| title_full_unstemmed | Prognostic factors for survival in patients with metastatic lung adenocarcinoma: An analysis of the SEER database |
| title_short | Prognostic factors for survival in patients with metastatic lung adenocarcinoma: An analysis of the SEER database |
| title_sort | Prognostic factors for survival in patients with metastatic lung adenocarcinoma: An analysis of the SEER database |
| topic | Lung adenocarcinoma Metastasis Non-small cell lung cancer Overall survival Prognostic factor Adenocarcinoma del pulmón Metástasis neoplásica Carcinoma de pulmón de células no pequeñas Pronóstico Lung Aged Female Humans Male Neoplasm Metastasis Prognosis SEER Program Adenocarcinoma Lung Neoplasms Liver Neoplasms |
| topic_facet | Lung adenocarcinoma Metastasis Non-small cell lung cancer Overall survival Prognostic factor Adenocarcinoma del pulmón Metástasis neoplásica Carcinoma de pulmón de células no pequeñas Pronóstico Lung Aged Female Humans Male Neoplasm Metastasis Prognosis SEER Program Adenocarcinoma Lung Neoplasms Liver Neoplasms |
| url | http://hdl.handle.net/20.500.12105/17983 |