Hormone Targets for the Treatment of Sleep Disorders in Postmenopausal Women with Schizophrenia: A Narrative Review
While the early identification of insomnia in patients with schizophrenia is of clinical relevance, the use of specific compounds to treat insomnia has been studied less in postmenopausal women with schizophrenia. We aimed to explore the effects of melatonin, sex hormones, and raloxifene for the tre...
| Autores: | ; ; ; ; ; ; |
|---|---|
| Tipo de documento: | Artículo |
| Estado: | Published version |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/185036 |
| Acceso en línea: | https://hdl.handle.net/2445/185036 |
| Nivel de acceso: | Acceso abierto |
| Palabra clave: | Trastorns del son Menopausa Esquizofrènia Sleep disorders Menopause Schizophrenia |
| _version_ | 1878736896222298112 |
|---|---|
| author | González Rodríguez, Alexandre |
| author2 | Haba Rubio, José Usall i Rodié, Judith Natividad, Mentxu Soria, Virginia Labad, Javier Monreal, José Antonio |
| author2_role | author author author author author author |
| author_browse | González Rodríguez, Alexandre Haba Rubio, José Labad, Javier Monreal, José Antonio Natividad, Mentxu Soria, Virginia Usall i Rodié, Judith |
| author_facet | González Rodríguez, Alexandre Haba Rubio, José Usall i Rodié, Judith Natividad, Mentxu Soria, Virginia Labad, Javier Monreal, José Antonio |
| author_role | author |
| collection | Recercat. Dipósit de la Recerca de Catalunya |
| description | While the early identification of insomnia in patients with schizophrenia is of clinical relevance, the use of specific compounds to treat insomnia has been studied less in postmenopausal women with schizophrenia. We aimed to explore the effects of melatonin, sex hormones, and raloxifene for the treatment of insomnia in these populations. Although melatonin treatment improved the quality and efficiency of the sleep of patients with schizophrenia, few studies have explored its use in postmenopausal women with schizophrenia. The estrogen and progesterone pathways are dysregulated in major psychiatric disorders, such as in schizophrenia. While, in the context of menopause, a high testosterone-to-estradiol ratio is associated with higher frequencies of depressive symptoms, the effects of estradiol and other sex hormones on sleep disorders in postmenopausal women with schizophrenia has not been sufficiently investigated. Raloxifene, a selective estrogen receptor modulator, has shown positive effects on sleep disorders in postmenopausal women. Future studies should investigate the effectiveness of hormonal compounds on insomnia in postmenopausal women with schizophrenia. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_97364b2f9ee1567ca1bc1b4e3e2ec82d |
| institution | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| instname_str | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:recercat.cat:2445/185036 |
| publishDate | 2022 |
| publishDateSort | 2022 |
| publisher | MDPI AG |
| publisherStr | MDPI AG |
| reponame_str | Recercat. Dipósit de la Recerca de Catalunya |
| spelling | Hormone Targets for the Treatment of Sleep Disorders in Postmenopausal Women with Schizophrenia: A Narrative Review González Rodríguez, Alexandre Haba Rubio, José Usall i Rodié, Judith Natividad, Mentxu Soria, Virginia Labad, Javier Monreal, José Antonio Trastorns del son Menopausa Esquizofrènia Sleep disorders Menopause Schizophrenia While the early identification of insomnia in patients with schizophrenia is of clinical relevance, the use of specific compounds to treat insomnia has been studied less in postmenopausal women with schizophrenia. We aimed to explore the effects of melatonin, sex hormones, and raloxifene for the treatment of insomnia in these populations. Although melatonin treatment improved the quality and efficiency of the sleep of patients with schizophrenia, few studies have explored its use in postmenopausal women with schizophrenia. The estrogen and progesterone pathways are dysregulated in major psychiatric disorders, such as in schizophrenia. While, in the context of menopause, a high testosterone-to-estradiol ratio is associated with higher frequencies of depressive symptoms, the effects of estradiol and other sex hormones on sleep disorders in postmenopausal women with schizophrenia has not been sufficiently investigated. Raloxifene, a selective estrogen receptor modulator, has shown positive effects on sleep disorders in postmenopausal women. Future studies should investigate the effectiveness of hormonal compounds on insomnia in postmenopausal women with schizophrenia. MDPI AG https://hdl.handle.net/2445/185036 |
| spellingShingle | Hormone Targets for the Treatment of Sleep Disorders in Postmenopausal Women with Schizophrenia: A Narrative Review González Rodríguez, Alexandre Trastorns del son Menopausa Esquizofrènia Sleep disorders Menopause Schizophrenia |
| status_str | publishedVersion |
| title | Hormone Targets for the Treatment of Sleep Disorders in Postmenopausal Women with Schizophrenia: A Narrative Review |
| title_full | Hormone Targets for the Treatment of Sleep Disorders in Postmenopausal Women with Schizophrenia: A Narrative Review |
| title_fullStr | Hormone Targets for the Treatment of Sleep Disorders in Postmenopausal Women with Schizophrenia: A Narrative Review |
| title_full_unstemmed | Hormone Targets for the Treatment of Sleep Disorders in Postmenopausal Women with Schizophrenia: A Narrative Review |
| title_short | Hormone Targets for the Treatment of Sleep Disorders in Postmenopausal Women with Schizophrenia: A Narrative Review |
| title_sort | Hormone Targets for the Treatment of Sleep Disorders in Postmenopausal Women with Schizophrenia: A Narrative Review |
| topic | Trastorns del son Menopausa Esquizofrènia Sleep disorders Menopause Schizophrenia |
| topic_facet | Trastorns del son Menopausa Esquizofrènia Sleep disorders Menopause Schizophrenia |
| url | https://hdl.handle.net/2445/185036 |