Efficacy and safety of pallidal stimulation in primary dystonia: results of the Spanish multicentric study

Background: Dystonia is a complex clinical syndrome originated by a wide range of aetiologies. The diagnosis of dystonia is made after the evaluation of aetiological, phenomenological and genetic factors.(1) Medications, except in patients with dopa-responsive dystonia, are of limited efficacy. Botu...

Full description

Authors: Valldeoriola, F; Regidor, I; Minguez-Castellanos, A; Lezcano, E; Garcia-Ruiz, P; Rojo, A; Salvador, A; Castro, A; Grandas, F; Kulisevsky, J; Marti, MJ; Martinez-Martin, P; Relova, L; Rumia, J; Camara, A; Burguera, JA; Linazasoro, G; de Val, JL; Obeso, J; Rodriguez-Oroz, MC; Tolosa, E
Format: Article
Status:Published version
Publication date:2010
Country:España
Institution:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repository:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p12880
Online Access:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=12880
https://hal.science/hal-00552775
Access Level:Open access
Summary:Background: Dystonia is a complex clinical syndrome originated by a wide range of aetiologies. The diagnosis of dystonia is made after the evaluation of aetiological, phenomenological and genetic factors.(1) Medications, except in patients with dopa-responsive dystonia, are of limited efficacy. Botulinum toxin injections are not applicable to patients with generalised dystonia, since many muscular groups contribute to disability.(2) Clinical studies in children and adults with primary generalised dystonia (PGD) have reported beneficial effects of bilateral GPi deep brain stimulation (DBS) in both motor symptoms and disability produced by dystonia(3-5) as well as a favourable impact of DBS in the health-related quality of life (HRQoL).(6) Some clinical aspects of GPi stimulation in primary dystonia still remain controversial such as the influence of disease duration or age at onset in determining the postoperative clinical outcome. Results: The authors report the results of a multicentric study designed to assess the tolerability and clinical effects of bilateral pallidal DBS on motor impairment, functional disability, quality of life, pain and mood in patients with medically refractory primary generalised or segmental dystonia.

Similar Items