Contribution of CD4+ cells in the emotional alterations induced by endometriosis in mice
Endometriosis is a disease defined by the presence of endometrial tissue in extrauterine locations. This chronic condition is frequently associated with pain and emotional disorders and has been related with altered immune function. However, the specific involvement of immune cells in pain and behav...
| Authors: | ; ; |
|---|---|
| Format: | Article |
| Status: | Published version |
| Publication date: | 2022 |
| Country: | España |
| Institution: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repository: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:10230/55162 |
| Online Access: | http://hdl.handle.net/10230/55162 http://dx.doi.org/10.3389/fnbeh.2022.946975 |
| Access Level: | Open access |
| Keyword: | CD4 Anxiety Chronic pelvic pain Endometriosis Female Neuroinflammatory |
| _version_ | 1878736855877287936 |
|---|---|
| author | Escudero Lara, Alejandra, 1992- |
| author2 | Cabañero Ferri, David Maldonado, Rafael, 1961- |
| author2_role | author author |
| author_browse | Cabañero Ferri, David Escudero Lara, Alejandra, 1992- Maldonado, Rafael, 1961- |
| author_facet | Escudero Lara, Alejandra, 1992- Cabañero Ferri, David Maldonado, Rafael, 1961- |
| author_role | author |
| collection | Recercat. Dipósit de la Recerca de Catalunya |
| description | Endometriosis is a disease defined by the presence of endometrial tissue in extrauterine locations. This chronic condition is frequently associated with pain and emotional disorders and has been related with altered immune function. However, the specific involvement of immune cells in pain and behavioral symptoms of endometriosis has not been yet elucidated. Here, we implement a mouse model of non-surgical endometriosis in which immunocompetent mice develop abdomino-pelvic hypersensitivity, cognitive deficits, anxiety and depressive-like behaviors. This behavioral phenotype correlates with expression of inflammatory markers in the brain, including the immune cell marker CD4. Depletion of CD4 + cells decreases the anxiety-like behavior of mice subjected to the endometriosis model, whereas abdomino-pelvic hypersensitivity, depressive-like behavior and cognitive deficits remain unaltered. The present data reveal the involvement of the immune response characterized by CD4 + white blood cells in the anxiety-like behavior induced by endometriosis in mice. This model, which recapitulates the symptoms of human endometriosis, may be a useful tool to study the immune mechanisms involved in pain and behavioral alterations associated to endometriosis. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_968916d84d8e8a0bfecc047f4c8bf35e |
| institution | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| instname_str | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:recercat.cat:10230/55162 |
| publishDate | 2022 |
| publishDateSort | 2022 |
| publisher | Frontiers |
| publisherStr | Frontiers |
| reponame_str | Recercat. Dipósit de la Recerca de Catalunya |
| spelling | Contribution of CD4+ cells in the emotional alterations induced by endometriosis in mice Escudero Lara, Alejandra, 1992- Cabañero Ferri, David Maldonado, Rafael, 1961- CD4 Anxiety Chronic pelvic pain Endometriosis Female Neuroinflammatory Endometriosis is a disease defined by the presence of endometrial tissue in extrauterine locations. This chronic condition is frequently associated with pain and emotional disorders and has been related with altered immune function. However, the specific involvement of immune cells in pain and behavioral symptoms of endometriosis has not been yet elucidated. Here, we implement a mouse model of non-surgical endometriosis in which immunocompetent mice develop abdomino-pelvic hypersensitivity, cognitive deficits, anxiety and depressive-like behaviors. This behavioral phenotype correlates with expression of inflammatory markers in the brain, including the immune cell marker CD4. Depletion of CD4 + cells decreases the anxiety-like behavior of mice subjected to the endometriosis model, whereas abdomino-pelvic hypersensitivity, depressive-like behavior and cognitive deficits remain unaltered. The present data reveal the involvement of the immune response characterized by CD4 + white blood cells in the anxiety-like behavior induced by endometriosis in mice. This model, which recapitulates the symptoms of human endometriosis, may be a useful tool to study the immune mechanisms involved in pain and behavioral alterations associated to endometriosis. “Instituto de Salud Carlos III,” “Redes temáticas de investigación cooperativa en salud—Red de trastornos adictivos” (#RD16/0017/0020), “Ministerio de Ciencia e Innovación” MICIN y “Agencia Estatal de Investigación” AEI (#PID2020-120029GBI00/MICIN/AEI/10.13039/50110001 1033), and “Generalitat de Catalunya- Agència de Gestió d’Ajuts Universitaris i de Recerca-AGAUR” (#2017-SGR-669 and #ICREA Acadèmia2020) to RM are acknowledged. Frontiers http://hdl.handle.net/10230/55162 http://dx.doi.org/10.3389/fnbeh.2022.946975 |
| spellingShingle | Contribution of CD4+ cells in the emotional alterations induced by endometriosis in mice Escudero Lara, Alejandra, 1992- CD4 Anxiety Chronic pelvic pain Endometriosis Female Neuroinflammatory |
| status_str | publishedVersion |
| title | Contribution of CD4+ cells in the emotional alterations induced by endometriosis in mice |
| title_full | Contribution of CD4+ cells in the emotional alterations induced by endometriosis in mice |
| title_fullStr | Contribution of CD4+ cells in the emotional alterations induced by endometriosis in mice |
| title_full_unstemmed | Contribution of CD4+ cells in the emotional alterations induced by endometriosis in mice |
| title_short | Contribution of CD4+ cells in the emotional alterations induced by endometriosis in mice |
| title_sort | Contribution of CD4+ cells in the emotional alterations induced by endometriosis in mice |
| topic | CD4 Anxiety Chronic pelvic pain Endometriosis Female Neuroinflammatory |
| topic_facet | CD4 Anxiety Chronic pelvic pain Endometriosis Female Neuroinflammatory |
| url | http://hdl.handle.net/10230/55162 http://dx.doi.org/10.3389/fnbeh.2022.946975 |