The Influence of Gut Microbiota on Neurogenesis: Evidence and Hopes
Adult neurogenesis (i.e., the life-long generation of new neurons from undifferentiated neuronal precursors in the adult brain) may contribute to brain repair after damage, and participates in plasticity-related processes including memory, cognition, mood and sensory functions. Among the many intrin...
| Authors: | ; ; |
|---|---|
| Format: | Article |
| Publication date: | 2022 |
| Country: | España |
| Institution: | Instituto de Salud Carlos III (ISCIII) |
| Repository: | Repisalud |
| Language: | English |
| OAI Identifier: | oai:repisalud.isciii.es:20.500.12105/23540 |
| Online Access: | https://hdl.handle.net/20.500.12105/23540 |
| Access Level: | Open access |
| Keyword: | Gut microbiota Gut-brain axis Adult neurogenesis Ageing Neural stem cells Neurodegeneration Nutrients Antioxidants Polyphenols Animales Microbiota Neurogénesis Encéfalo Prebióticos Microbioma Gastrointestinal Brain Neurogenesis Gastrointestinal Microbiome Prebiotics Animals |
| _version_ | 1878736612392697856 |
|---|---|
| author | Sarubbo, Fiorella |
| author2 | Cavallucci, Virve Pani, Giovambattista |
| author2_role | author author |
| author_browse | Cavallucci, Virve Pani, Giovambattista Sarubbo, Fiorella |
| author_facet | Sarubbo, Fiorella Cavallucci, Virve Pani, Giovambattista |
| author_role | author |
| collection | Repisalud |
| description | Adult neurogenesis (i.e., the life-long generation of new neurons from undifferentiated neuronal precursors in the adult brain) may contribute to brain repair after damage, and participates in plasticity-related processes including memory, cognition, mood and sensory functions. Among the many intrinsic (oxidative stress, inflammation, and ageing), and extrinsic (environmental pollution, lifestyle, and diet) factors deemed to impact neurogenesis, significant attention has been recently attracted by the myriad of saprophytic microorganismal communities inhabiting the intestinal ecosystem and collectively referred to as the gut microbiota. A growing body of evidence, mainly from animal studies, reveal the influence of microbiota and its disease-associated imbalances on neural stem cell proliferative and differentiative activities in brain neurogenic niches. On the other hand, the long-claimed pro-neurogenic activity of natural dietary compounds endowed with antioxidants and anti-inflammatory properties (such as polyphenols, polyunsaturated fatty acids, or pro/prebiotics) may be mediated, at least in part, by their action on the intestinal microflora. The purpose of this review is to summarise the available information regarding the influence of the gut microbiota on neurogenesis, analyse the possible underlying mechanisms, and discuss the potential implications of this emerging knowledge for the fight against neurodegeneration and brain ageing. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_921f53f599b7bbedea46e2dbdde6e7e0 |
| institution | Instituto de Salud Carlos III (ISCIII) |
| instname_str | Instituto de Salud Carlos III (ISCIII) |
| language | eng |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:repisalud.isciii.es:20.500.12105/23540 |
| publishDate | 2022 |
| publishDateSort | 2022 |
| publisher | Multidisciplinary Digital Publishing Institute (MDPI) |
| publisherStr | Multidisciplinary Digital Publishing Institute (MDPI) |
| reponame_str | Repisalud |
| spelling | The Influence of Gut Microbiota on Neurogenesis: Evidence and Hopes Sarubbo, Fiorella Cavallucci, Virve Pani, Giovambattista Gut microbiota Gut-brain axis Adult neurogenesis Ageing Neural stem cells Neurodegeneration Nutrients Antioxidants Polyphenols Animales Microbiota Neurogénesis Encéfalo Prebióticos Microbioma Gastrointestinal Brain Neurogenesis Gastrointestinal Microbiome Prebiotics Animals Adult neurogenesis (i.e., the life-long generation of new neurons from undifferentiated neuronal precursors in the adult brain) may contribute to brain repair after damage, and participates in plasticity-related processes including memory, cognition, mood and sensory functions. Among the many intrinsic (oxidative stress, inflammation, and ageing), and extrinsic (environmental pollution, lifestyle, and diet) factors deemed to impact neurogenesis, significant attention has been recently attracted by the myriad of saprophytic microorganismal communities inhabiting the intestinal ecosystem and collectively referred to as the gut microbiota. A growing body of evidence, mainly from animal studies, reveal the influence of microbiota and its disease-associated imbalances on neural stem cell proliferative and differentiative activities in brain neurogenic niches. On the other hand, the long-claimed pro-neurogenic activity of natural dietary compounds endowed with antioxidants and anti-inflammatory properties (such as polyphenols, polyunsaturated fatty acids, or pro/prebiotics) may be mediated, at least in part, by their action on the intestinal microflora. The purpose of this review is to summarise the available information regarding the influence of the gut microbiota on neurogenesis, analyse the possible underlying mechanisms, and discuss the potential implications of this emerging knowledge for the fight against neurodegeneration and brain ageing. Multidisciplinary Digital Publishing Institute (MDPI) https://hdl.handle.net/20.500.12105/23540 |
| spellingShingle | The Influence of Gut Microbiota on Neurogenesis: Evidence and Hopes Sarubbo, Fiorella Gut microbiota Gut-brain axis Adult neurogenesis Ageing Neural stem cells Neurodegeneration Nutrients Antioxidants Polyphenols Animales Microbiota Neurogénesis Encéfalo Prebióticos Microbioma Gastrointestinal Brain Neurogenesis Gastrointestinal Microbiome Prebiotics Animals |
| title | The Influence of Gut Microbiota on Neurogenesis: Evidence and Hopes |
| title_full | The Influence of Gut Microbiota on Neurogenesis: Evidence and Hopes |
| title_fullStr | The Influence of Gut Microbiota on Neurogenesis: Evidence and Hopes |
| title_full_unstemmed | The Influence of Gut Microbiota on Neurogenesis: Evidence and Hopes |
| title_short | The Influence of Gut Microbiota on Neurogenesis: Evidence and Hopes |
| title_sort | The Influence of Gut Microbiota on Neurogenesis: Evidence and Hopes |
| topic | Gut microbiota Gut-brain axis Adult neurogenesis Ageing Neural stem cells Neurodegeneration Nutrients Antioxidants Polyphenols Animales Microbiota Neurogénesis Encéfalo Prebióticos Microbioma Gastrointestinal Brain Neurogenesis Gastrointestinal Microbiome Prebiotics Animals |
| topic_facet | Gut microbiota Gut-brain axis Adult neurogenesis Ageing Neural stem cells Neurodegeneration Nutrients Antioxidants Polyphenols Animales Microbiota Neurogénesis Encéfalo Prebióticos Microbioma Gastrointestinal Brain Neurogenesis Gastrointestinal Microbiome Prebiotics Animals |
| url | https://hdl.handle.net/20.500.12105/23540 |