Predictors and changes of physical activity in idiopathic pulmonary fibrosis
Background: Different clinical predictors of physical activity (PA) have been described in idiopathic pulmonary fibrosis (IPF), but studies are lacking evaluating the potential role of muscle strength and anxiety and depression symptoms in PA limitation. Moreover, little is known about the impact of...
| Autores: | ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; |
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| Tipo de documento: | Artículo |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Lenguaje: | Inglés |
| OAI Identifier: | oai:ddd.uab.cat:275192 |
| Acceso en línea: | https://ddd.uab.cat/record/275192 https://dx.doi.org/urn:doi:10.1186/s12890-022-02134-4 |
| Nivel de acceso: | Acceso abierto |
| Palabra clave: | Physical activity Idiopathic pulmonary fibrosis Predictors Muscle strength Depression Prognosis |
| _version_ | 1878736389433982976 |
|---|---|
| author | Badenes-Bonet, Diana|||0000-0001-8034-0838 |
| author2 | Rodó-Pin, Anna Castillo, Diego|||0000-0002-4862-3595 Vicens-Zygmunt, Vanesa|||0000-0002-0940-3215 Bermudo, Guadalupe|||0000-0002-2010-7679 Hernández-González, Fernanda Portillo, Karina|||0000-0002-7804-1051 Martínez-Llorens, Juana Chalela, Roberto|||0000-0003-4835-3852 Caguana, Oswaldo Sellarés, Jacobo|||0000-0001-5403-5688 Molina Molina, Maria|||0000-0002-1852-1723 Duran-Jordà, Xavier|||0000-0001-8517-9254 Gea Guiral, Joaquim|||0000-0001-8718-7346 Rodríguez-Chiaradia, Diego A.|||0000-0002-8566-4011 Balcells, Eva|||0000-0001-5334-549X |
| author2_role | author author author author author author author author author author author author author author author |
| author_browse | Badenes-Bonet, Diana|||0000-0001-8034-0838 Balcells, Eva|||0000-0001-5334-549X Bermudo, Guadalupe|||0000-0002-2010-7679 Caguana, Oswaldo Castillo, Diego|||0000-0002-4862-3595 Chalela, Roberto|||0000-0003-4835-3852 Duran-Jordà, Xavier|||0000-0001-8517-9254 Gea Guiral, Joaquim|||0000-0001-8718-7346 Hernández-González, Fernanda Martínez-Llorens, Juana Molina Molina, Maria|||0000-0002-1852-1723 Portillo, Karina|||0000-0002-7804-1051 Rodríguez-Chiaradia, Diego A.|||0000-0002-8566-4011 Rodó-Pin, Anna Sellarés, Jacobo|||0000-0001-5403-5688 Vicens-Zygmunt, Vanesa|||0000-0002-0940-3215 |
| author_facet | Badenes-Bonet, Diana|||0000-0001-8034-0838 Rodó-Pin, Anna Castillo, Diego|||0000-0002-4862-3595 Vicens-Zygmunt, Vanesa|||0000-0002-0940-3215 Bermudo, Guadalupe|||0000-0002-2010-7679 Hernández-González, Fernanda Portillo, Karina|||0000-0002-7804-1051 Martínez-Llorens, Juana Chalela, Roberto|||0000-0003-4835-3852 Caguana, Oswaldo Sellarés, Jacobo|||0000-0001-5403-5688 Molina Molina, Maria|||0000-0002-1852-1723 Duran-Jordà, Xavier|||0000-0001-8517-9254 Gea Guiral, Joaquim|||0000-0001-8718-7346 Rodríguez-Chiaradia, Diego A.|||0000-0002-8566-4011 Balcells, Eva|||0000-0001-5334-549X |
| author_role | author |
| collection | Dipòsit Digital de Documents de la UAB |
| description | Background: Different clinical predictors of physical activity (PA) have been described in idiopathic pulmonary fibrosis (IPF), but studies are lacking evaluating the potential role of muscle strength and anxiety and depression symptoms in PA limitation. Moreover, little is known about the impact of changes in PA in the course of the disease. The aim of the present study was to investigate the relationship between baseline PA and a wide range of variables in IPF, to assess its longitudinal changes at 12 months and its impact on progression free-survival. Methods: PA was assessed by accelerometer and physiological, clinical, psychological factors and health-related quality of life were evaluated in subjects with IPF at baseline and at 12 month follow-up. Predictors of PA were determined at baseline, evolution of PA parameters was described and the prognostic role of PA evolution was also established. Results: Forty participants with IPF were included and 22 completed the follow-up. At baseline, subjects performed 5765 (3442) daily steps and spent 64 (44) minutes/day in moderate to vigorous PA. Multivariate regression models showed that at baseline, a lower six-minute walked distance, lower quadriceps strength (QMVC), and a higher depression score in the Hospital Anxiety and Depression scale were associated to lower daily step number. In addition, being in (Gender-Age-Physiology) GAP III stage, having a BMI ≥ 25 kg/m and lower QMVC or maximum inspiratory pressure were factors associated with sedentary behaviour. Adjusted for age, gender and forced vital capacity (FVC) (%pred.) a lower progression-free survival was evidenced in those subjects that decreased PA compared to those that maintained, or even increased it, at 12 months [HR 12.1 (95% CI, 1.9-78.8); p = 0.009]. Conclusion: Among a wide range of variables, muscle strength and depression symptoms have a predominant role in PA in IPF patients. Daily PA behaviour and its evolution should be considered in IPF clinical assessment and as a potential complementary indicator of disease prognosis. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_8e254a7f9d801a7b5b7026deaeb657d7 |
| institution | Universitat Autònoma de Barcelona |
| instname_str | Universitat Autònoma de Barcelona |
| language | eng |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:ddd.uab.cat:275192 |
| publishDate | 2022 |
| publishDateSort | 2022 |
| reponame_str | Dipòsit Digital de Documents de la UAB |
| spelling | Predictors and changes of physical activity in idiopathic pulmonary fibrosis Badenes-Bonet, Diana|||0000-0001-8034-0838 Rodó-Pin, Anna Castillo, Diego|||0000-0002-4862-3595 Vicens-Zygmunt, Vanesa|||0000-0002-0940-3215 Bermudo, Guadalupe|||0000-0002-2010-7679 Hernández-González, Fernanda Portillo, Karina|||0000-0002-7804-1051 Martínez-Llorens, Juana Chalela, Roberto|||0000-0003-4835-3852 Caguana, Oswaldo Sellarés, Jacobo|||0000-0001-5403-5688 Molina Molina, Maria|||0000-0002-1852-1723 Duran-Jordà, Xavier|||0000-0001-8517-9254 Gea Guiral, Joaquim|||0000-0001-8718-7346 Rodríguez-Chiaradia, Diego A.|||0000-0002-8566-4011 Balcells, Eva|||0000-0001-5334-549X Physical activity Idiopathic pulmonary fibrosis Predictors Muscle strength Depression Prognosis Background: Different clinical predictors of physical activity (PA) have been described in idiopathic pulmonary fibrosis (IPF), but studies are lacking evaluating the potential role of muscle strength and anxiety and depression symptoms in PA limitation. Moreover, little is known about the impact of changes in PA in the course of the disease. The aim of the present study was to investigate the relationship between baseline PA and a wide range of variables in IPF, to assess its longitudinal changes at 12 months and its impact on progression free-survival. Methods: PA was assessed by accelerometer and physiological, clinical, psychological factors and health-related quality of life were evaluated in subjects with IPF at baseline and at 12 month follow-up. Predictors of PA were determined at baseline, evolution of PA parameters was described and the prognostic role of PA evolution was also established. Results: Forty participants with IPF were included and 22 completed the follow-up. At baseline, subjects performed 5765 (3442) daily steps and spent 64 (44) minutes/day in moderate to vigorous PA. Multivariate regression models showed that at baseline, a lower six-minute walked distance, lower quadriceps strength (QMVC), and a higher depression score in the Hospital Anxiety and Depression scale were associated to lower daily step number. In addition, being in (Gender-Age-Physiology) GAP III stage, having a BMI ≥ 25 kg/m and lower QMVC or maximum inspiratory pressure were factors associated with sedentary behaviour. Adjusted for age, gender and forced vital capacity (FVC) (%pred.) a lower progression-free survival was evidenced in those subjects that decreased PA compared to those that maintained, or even increased it, at 12 months [HR 12.1 (95% CI, 1.9-78.8); p = 0.009]. Conclusion: Among a wide range of variables, muscle strength and depression symptoms have a predominant role in PA in IPF patients. Daily PA behaviour and its evolution should be considered in IPF clinical assessment and as a potential complementary indicator of disease prognosis. https://ddd.uab.cat/record/275192 https://dx.doi.org/urn:doi:10.1186/s12890-022-02134-4 |
| spellingShingle | Predictors and changes of physical activity in idiopathic pulmonary fibrosis Badenes-Bonet, Diana|||0000-0001-8034-0838 Physical activity Idiopathic pulmonary fibrosis Predictors Muscle strength Depression Prognosis |
| title | Predictors and changes of physical activity in idiopathic pulmonary fibrosis |
| title_full | Predictors and changes of physical activity in idiopathic pulmonary fibrosis |
| title_fullStr | Predictors and changes of physical activity in idiopathic pulmonary fibrosis |
| title_full_unstemmed | Predictors and changes of physical activity in idiopathic pulmonary fibrosis |
| title_short | Predictors and changes of physical activity in idiopathic pulmonary fibrosis |
| title_sort | Predictors and changes of physical activity in idiopathic pulmonary fibrosis |
| topic | Physical activity Idiopathic pulmonary fibrosis Predictors Muscle strength Depression Prognosis |
| topic_facet | Physical activity Idiopathic pulmonary fibrosis Predictors Muscle strength Depression Prognosis |
| url | https://ddd.uab.cat/record/275192 https://dx.doi.org/urn:doi:10.1186/s12890-022-02134-4 |