Postsystolic thickening is a potential new clinical sign of injured myocardium in marfan syndrome.
The mechanisms leading to cardiac remodeling in Marfan syndrome (MFS) are a matter of debate since it could be either due to structural dysfunction of the myocardial extracellular matrix or to increased afterload caused by the dilated aorta. We aim to characterize the presence of abnormal myocardial...
| Autores: | ; ; ; ; ; ; ; ; |
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| Tipo de documento: | Artículo |
| Estado: | Published version |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/186682 |
| Acceso en línea: | https://hdl.handle.net/2445/186682 |
| Nivel de acceso: | Acceso abierto |
| Palabra clave: | Miocardi Ventricles cardíacs Malalties de l'aorta Myocardium Ventricle of heart Aorta diseases |
| _version_ | 1878736274156683264 |
|---|---|
| author | Mas Stachurska, Aleksandra |
| author2 | Egea Guri, Gustavo de Bruin-Bon, R Rudenick, Paula Sanchis Ruiz, Laura Bouma, Berto J. Mulder, Barbara J. Bijnens, Bart Sitges Carreño, Marta |
| author2_role | author author author author author author author author |
| author_browse | Bijnens, Bart Bouma, Berto J. Egea Guri, Gustavo Mas Stachurska, Aleksandra Mulder, Barbara J. Rudenick, Paula Sanchis Ruiz, Laura Sitges Carreño, Marta de Bruin-Bon, R |
| author_facet | Mas Stachurska, Aleksandra Egea Guri, Gustavo de Bruin-Bon, R Rudenick, Paula Sanchis Ruiz, Laura Bouma, Berto J. Mulder, Barbara J. Bijnens, Bart Sitges Carreño, Marta |
| author_role | author |
| collection | Recercat. Dipósit de la Recerca de Catalunya |
| description | The mechanisms leading to cardiac remodeling in Marfan syndrome (MFS) are a matter of debate since it could be either due to structural dysfunction of the myocardial extracellular matrix or to increased afterload caused by the dilated aorta. We aim to characterize the presence of abnormal myocardial function in MFS and to investigate its potential association with increased afterload. Aorta, left ventricle (LV) and the postsystolic thickening (PST) were analyzed in echocardiography in Fbn1C1039G/+ mice and in patients with MFS in comparison with wild type (WT) mice and healthy humans. PST was more frequent in MFS than in WT mice (p< 0.05). MFS mice with PST showed larger aorta than those without PST. Patients with MFS showed larger aorta, poorer LV function and a higher prevalence of PST (56%) than did the healthy controls (23%); p= 0.003. Blood pressure was similar. The higher prevalence of PST in an experimental murine model and in MFS patients, regardless of systemic arterial pressure, suggests an increased afterload on the LV myocardium. This fnding supports the use of PST as an indicator of myocardial damage and encourage searching for novel early preventive therapy |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_8c2f724be2cf94fa9e323e41d50090e3 |
| institution | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| instname_str | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:recercat.cat:2445/186682 |
| publishDate | 2021 |
| publishDateSort | 2021 |
| publisher | Nature Publishing Group |
| publisherStr | Nature Publishing Group |
| reponame_str | Recercat. Dipósit de la Recerca de Catalunya |
| spelling | Postsystolic thickening is a potential new clinical sign of injured myocardium in marfan syndrome. Mas Stachurska, Aleksandra Egea Guri, Gustavo de Bruin-Bon, R Rudenick, Paula Sanchis Ruiz, Laura Bouma, Berto J. Mulder, Barbara J. Bijnens, Bart Sitges Carreño, Marta Miocardi Ventricles cardíacs Malalties de l'aorta Myocardium Ventricle of heart Aorta diseases The mechanisms leading to cardiac remodeling in Marfan syndrome (MFS) are a matter of debate since it could be either due to structural dysfunction of the myocardial extracellular matrix or to increased afterload caused by the dilated aorta. We aim to characterize the presence of abnormal myocardial function in MFS and to investigate its potential association with increased afterload. Aorta, left ventricle (LV) and the postsystolic thickening (PST) were analyzed in echocardiography in Fbn1C1039G/+ mice and in patients with MFS in comparison with wild type (WT) mice and healthy humans. PST was more frequent in MFS than in WT mice (p< 0.05). MFS mice with PST showed larger aorta than those without PST. Patients with MFS showed larger aorta, poorer LV function and a higher prevalence of PST (56%) than did the healthy controls (23%); p= 0.003. Blood pressure was similar. The higher prevalence of PST in an experimental murine model and in MFS patients, regardless of systemic arterial pressure, suggests an increased afterload on the LV myocardium. This fnding supports the use of PST as an indicator of myocardial damage and encourage searching for novel early preventive therapy Nature Publishing Group https://hdl.handle.net/2445/186682 |
| spellingShingle | Postsystolic thickening is a potential new clinical sign of injured myocardium in marfan syndrome. Mas Stachurska, Aleksandra Miocardi Ventricles cardíacs Malalties de l'aorta Myocardium Ventricle of heart Aorta diseases |
| status_str | publishedVersion |
| title | Postsystolic thickening is a potential new clinical sign of injured myocardium in marfan syndrome. |
| title_full | Postsystolic thickening is a potential new clinical sign of injured myocardium in marfan syndrome. |
| title_fullStr | Postsystolic thickening is a potential new clinical sign of injured myocardium in marfan syndrome. |
| title_full_unstemmed | Postsystolic thickening is a potential new clinical sign of injured myocardium in marfan syndrome. |
| title_short | Postsystolic thickening is a potential new clinical sign of injured myocardium in marfan syndrome. |
| title_sort | Postsystolic thickening is a potential new clinical sign of injured myocardium in marfan syndrome. |
| topic | Miocardi Ventricles cardíacs Malalties de l'aorta Myocardium Ventricle of heart Aorta diseases |
| topic_facet | Miocardi Ventricles cardíacs Malalties de l'aorta Myocardium Ventricle of heart Aorta diseases |
| url | https://hdl.handle.net/2445/186682 |