Infectious keratoconjunctivitis and occurrence of Mycoplasma conjunctivae and Chlamydiaceae in small domestic ruminants from Central Karakoram, Pakistan
Infectious keratoconjunctivitis (IKC) is a contagious eye disease primarily caused by Mycoplasma conjunctivae in domestic and wild Caprinae. Chlamydophila species have also been detected in ruminants with IKC. The objectives of this study are to investigate the ocular infection of M. conjunctivae an...
| Authors: | ; ; ; ; ; ; |
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| Format: | Article |
| Publication date: | 2017 |
| Country: | España |
| Institution: | Universitat Autònoma de Barcelona |
| Repository: | Dipòsit Digital de Documents de la UAB |
| Language: | English |
| OAI Identifier: | oai:ddd.uab.cat:186303 |
| Online Access: | https://ddd.uab.cat/record/186303 https://dx.doi.org/urn:doi:10.1136/vr.103948 |
| Access Level: | Open access |
| Keyword: | Chlamydophila pecorum Coinfection Goat Infectious keratoconjunctivitis Sheep Wildlife livestock interface |
| _version_ | 1878736238159069184 |
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| author | Fernández Aguilar, Xavier|||0000-0002-4939-6048 |
| author2 | Rossi, Luca|||0000-0001-6829-5229 Cabezón Ponsoda, Óscar|||0000-0001-7543-8371 Giorgino, Andrea Victoriano Llopis, Isis Frey, Joachim|||0000-0001-9133-0280 López Olvera, Jorge R.|||0000-0002-2999-3451 |
| author2_role | author author author author author author |
| author_browse | Cabezón Ponsoda, Óscar|||0000-0001-7543-8371 Fernández Aguilar, Xavier|||0000-0002-4939-6048 Frey, Joachim|||0000-0001-9133-0280 Giorgino, Andrea López Olvera, Jorge R.|||0000-0002-2999-3451 Rossi, Luca|||0000-0001-6829-5229 Victoriano Llopis, Isis |
| author_facet | Fernández Aguilar, Xavier|||0000-0002-4939-6048 Rossi, Luca|||0000-0001-6829-5229 Cabezón Ponsoda, Óscar|||0000-0001-7543-8371 Giorgino, Andrea Victoriano Llopis, Isis Frey, Joachim|||0000-0001-9133-0280 López Olvera, Jorge R.|||0000-0002-2999-3451 |
| author_role | author |
| collection | Dipòsit Digital de Documents de la UAB |
| description | Infectious keratoconjunctivitis (IKC) is a contagious eye disease primarily caused by Mycoplasma conjunctivae in domestic and wild Caprinae. Chlamydophila species have also been detected in ruminants with IKC. The objectives of this study are to investigate the ocular infection of M. conjunctivae and Chlamydiaceae and assess its interaction in relation to IKC in sheep and goats from remote communities around the Central Karakoram National Park in Pakistan, performing a combination of cross-sectional and case-control study design. Mostly asymptomatic and endemic infections of M. conjunctivae and Chlamydiaceae were found in sheep (19.3 per cent and 4.5 per cent, respectively) and goats (9.5 per cent and 1.9 per cent, respectively) from all communities, assessed by qPCR. Prevalence significantly differed between species only for M. conjunctivae (P=0.0184), which was also more prevalent in younger sheep (P<0.01). Chlamydophila pecorum was identified by sequencing and was related with IKC only when coinfection with M. conjunctivae occurred, which suggest a synergic interaction. Cluster analysis of M. conjunctivae strains revealed higher diversity of strains than expected, evidenced interspecific transmission and suggested a higher local livestock trade than previously assumed. These results highlight the widespread occurrence of M conjunctivae in sheep worldwide and its implications for wildlife should be assessed from a conservation perspective. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_8b8a44c7daffcbc55b43cd86a7582d3b |
| institution | Universitat Autònoma de Barcelona |
| instname_str | Universitat Autònoma de Barcelona |
| language | eng |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:ddd.uab.cat:186303 |
| publishDate | 2017 |
| publishDateSort | 2017 |
| reponame_str | Dipòsit Digital de Documents de la UAB |
| spelling | Infectious keratoconjunctivitis and occurrence of Mycoplasma conjunctivae and Chlamydiaceae in small domestic ruminants from Central Karakoram, Pakistan Fernández Aguilar, Xavier|||0000-0002-4939-6048 Rossi, Luca|||0000-0001-6829-5229 Cabezón Ponsoda, Óscar|||0000-0001-7543-8371 Giorgino, Andrea Victoriano Llopis, Isis Frey, Joachim|||0000-0001-9133-0280 López Olvera, Jorge R.|||0000-0002-2999-3451 Chlamydophila pecorum Coinfection Goat Infectious keratoconjunctivitis Sheep Wildlife livestock interface Infectious keratoconjunctivitis (IKC) is a contagious eye disease primarily caused by Mycoplasma conjunctivae in domestic and wild Caprinae. Chlamydophila species have also been detected in ruminants with IKC. The objectives of this study are to investigate the ocular infection of M. conjunctivae and Chlamydiaceae and assess its interaction in relation to IKC in sheep and goats from remote communities around the Central Karakoram National Park in Pakistan, performing a combination of cross-sectional and case-control study design. Mostly asymptomatic and endemic infections of M. conjunctivae and Chlamydiaceae were found in sheep (19.3 per cent and 4.5 per cent, respectively) and goats (9.5 per cent and 1.9 per cent, respectively) from all communities, assessed by qPCR. Prevalence significantly differed between species only for M. conjunctivae (P=0.0184), which was also more prevalent in younger sheep (P<0.01). Chlamydophila pecorum was identified by sequencing and was related with IKC only when coinfection with M. conjunctivae occurred, which suggest a synergic interaction. Cluster analysis of M. conjunctivae strains revealed higher diversity of strains than expected, evidenced interspecific transmission and suggested a higher local livestock trade than previously assumed. These results highlight the widespread occurrence of M conjunctivae in sheep worldwide and its implications for wildlife should be assessed from a conservation perspective. https://ddd.uab.cat/record/186303 https://dx.doi.org/urn:doi:10.1136/vr.103948 |
| spellingShingle | Infectious keratoconjunctivitis and occurrence of Mycoplasma conjunctivae and Chlamydiaceae in small domestic ruminants from Central Karakoram, Pakistan Fernández Aguilar, Xavier|||0000-0002-4939-6048 Chlamydophila pecorum Coinfection Goat Infectious keratoconjunctivitis Sheep Wildlife livestock interface |
| title | Infectious keratoconjunctivitis and occurrence of Mycoplasma conjunctivae and Chlamydiaceae in small domestic ruminants from Central Karakoram, Pakistan |
| title_full | Infectious keratoconjunctivitis and occurrence of Mycoplasma conjunctivae and Chlamydiaceae in small domestic ruminants from Central Karakoram, Pakistan |
| title_fullStr | Infectious keratoconjunctivitis and occurrence of Mycoplasma conjunctivae and Chlamydiaceae in small domestic ruminants from Central Karakoram, Pakistan |
| title_full_unstemmed | Infectious keratoconjunctivitis and occurrence of Mycoplasma conjunctivae and Chlamydiaceae in small domestic ruminants from Central Karakoram, Pakistan |
| title_short | Infectious keratoconjunctivitis and occurrence of Mycoplasma conjunctivae and Chlamydiaceae in small domestic ruminants from Central Karakoram, Pakistan |
| title_sort | Infectious keratoconjunctivitis and occurrence of Mycoplasma conjunctivae and Chlamydiaceae in small domestic ruminants from Central Karakoram, Pakistan |
| topic | Chlamydophila pecorum Coinfection Goat Infectious keratoconjunctivitis Sheep Wildlife livestock interface |
| topic_facet | Chlamydophila pecorum Coinfection Goat Infectious keratoconjunctivitis Sheep Wildlife livestock interface |
| url | https://ddd.uab.cat/record/186303 https://dx.doi.org/urn:doi:10.1136/vr.103948 |