Aspects of fractal kinetics of enzymatic reactions by Monte Carlo simulations
Using Monte Carlo simulations in 3D media we investigate the effect of macromolecular crowding on biochemical reactions following a Michaelis-Menten kinetics. In the system substrate and product particles cannot overlap and the effect of crowders mobility and concentration are examined. The simulati...
| Authors: | ; ; ; ; |
|---|---|
| Format: | Article |
| Status: | Published version |
| Publication date: | 2011 |
| Country: | España |
| Institution: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repository: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/158877 |
| Online Access: | https://hdl.handle.net/2445/158877 |
| Access Level: | Open access |
| Keyword: | Mètode de Montecarlo Mètodes de simulació Cinètica enzimàtica Monte Carlo method Simulation methods Enzyme kinetics |
| _version_ | 1878736209687085056 |
|---|---|
| author | Pitulice, Laura |
| author2 | Vilaseca i Font, Eudald Isvoran, Adriana Garcés, Josep Lluís Mas i Pujadas, Francesc |
| author2_role | author author author author |
| author_browse | Garcés, Josep Lluís Isvoran, Adriana Mas i Pujadas, Francesc Pitulice, Laura Vilaseca i Font, Eudald |
| author_facet | Pitulice, Laura Vilaseca i Font, Eudald Isvoran, Adriana Garcés, Josep Lluís Mas i Pujadas, Francesc |
| author_role | author |
| collection | Recercat. Dipósit de la Recerca de Catalunya |
| description | Using Monte Carlo simulations in 3D media we investigate the effect of macromolecular crowding on biochemical reactions following a Michaelis-Menten kinetics. In the system substrate and product particles cannot overlap and the effect of crowders mobility and concentration are examined. The simulation data are analyzed in terms of parameters describing the time dependence of the rate coefficient. Our results indicate a fractal like kinetics with different degrees of fractality depending on crowders features. Even though small, when crowders mobility rises kinetics fractality decreases due to enhancement of diffusional movements of the reactants. Instead, increasing the crowders density in the system kinetics fractality presents a smooth growth as less free volume is available for reactants. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_8b04bb8d4e45bca5827b4cac207c4ba2 |
| institution | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| instname_str | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:recercat.cat:2445/158877 |
| publishDate | 2011 |
| publishDateSort | 2011 |
| publisher | Universitatea de Vest din Timişoara |
| publisherStr | Universitatea de Vest din Timişoara |
| reponame_str | Recercat. Dipósit de la Recerca de Catalunya |
| spelling | Aspects of fractal kinetics of enzymatic reactions by Monte Carlo simulations Pitulice, Laura Vilaseca i Font, Eudald Isvoran, Adriana Garcés, Josep Lluís Mas i Pujadas, Francesc Mètode de Montecarlo Mètodes de simulació Cinètica enzimàtica Monte Carlo method Simulation methods Enzyme kinetics Using Monte Carlo simulations in 3D media we investigate the effect of macromolecular crowding on biochemical reactions following a Michaelis-Menten kinetics. In the system substrate and product particles cannot overlap and the effect of crowders mobility and concentration are examined. The simulation data are analyzed in terms of parameters describing the time dependence of the rate coefficient. Our results indicate a fractal like kinetics with different degrees of fractality depending on crowders features. Even though small, when crowders mobility rises kinetics fractality decreases due to enhancement of diffusional movements of the reactants. Instead, increasing the crowders density in the system kinetics fractality presents a smooth growth as less free volume is available for reactants. Universitatea de Vest din Timişoara https://hdl.handle.net/2445/158877 |
| spellingShingle | Aspects of fractal kinetics of enzymatic reactions by Monte Carlo simulations Pitulice, Laura Mètode de Montecarlo Mètodes de simulació Cinètica enzimàtica Monte Carlo method Simulation methods Enzyme kinetics |
| status_str | publishedVersion |
| title | Aspects of fractal kinetics of enzymatic reactions by Monte Carlo simulations |
| title_full | Aspects of fractal kinetics of enzymatic reactions by Monte Carlo simulations |
| title_fullStr | Aspects of fractal kinetics of enzymatic reactions by Monte Carlo simulations |
| title_full_unstemmed | Aspects of fractal kinetics of enzymatic reactions by Monte Carlo simulations |
| title_short | Aspects of fractal kinetics of enzymatic reactions by Monte Carlo simulations |
| title_sort | Aspects of fractal kinetics of enzymatic reactions by Monte Carlo simulations |
| topic | Mètode de Montecarlo Mètodes de simulació Cinètica enzimàtica Monte Carlo method Simulation methods Enzyme kinetics |
| topic_facet | Mètode de Montecarlo Mètodes de simulació Cinètica enzimàtica Monte Carlo method Simulation methods Enzyme kinetics |
| url | https://hdl.handle.net/2445/158877 |