Soluble Transferrin Receptor as Iron Deficiency Biomarker: Impact on Exercise Capacity in Heart Failure Patients
The soluble transferrin receptor (sTfR) is a marker of tissue iron status, which could indicate an increased iron demand at the tissue level. The impact of sTfR levels on functional capacity and quality of life (QoL) in non-anemic heart failure (HF) patients with otherwise normal systemic iron statu...
| Authors: | ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; |
|---|---|
| Format: | Article |
| Status: | Published version |
| Publication date: | 2023 |
| Country: | España |
| Institution: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repository: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/207858 |
| Online Access: | https://hdl.handle.net/2445/207858 |
| Access Level: | Open access |
| Keyword: | Dèficit de ferro Marcadors bioquímics Iron deficiency diseases Biochemical markers |
| _version_ | 1878736158710562816 |
|---|---|
| author | Ras Jiménez, Maria del Mar |
| author2 | Ramos Polo, Raúl Francesch Manzano, Josep Corbella Santano, Miriam Morillas Climent, Herminio Jose Bazán, Núria Jiménez Marrero, Santiago Garcimartín Cerezo, Paloma Yun Viladomat, Sergi Moliner Borja, Pedro Torres Cardús, Blanca Verdú Rotellar, Jose María Diez Lopez, Carles González Costello, José García Romero, Elena Frutos Seminario, Fernando de Triguero Llonch, Laura Enjuanes, Cristina Tajes Orduña, Marta Comín Colet, Josep |
| author2_role | author author author author author author author author author author author author author author author author author author author |
| author_browse | Comín Colet, Josep Corbella Santano, Miriam Diez Lopez, Carles Enjuanes, Cristina Francesch Manzano, Josep Frutos Seminario, Fernando de Garcimartín Cerezo, Paloma García Romero, Elena González Costello, José Jiménez Marrero, Santiago Jose Bazán, Núria Moliner Borja, Pedro Morillas Climent, Herminio Ramos Polo, Raúl Ras Jiménez, Maria del Mar Tajes Orduña, Marta Torres Cardús, Blanca Triguero Llonch, Laura Verdú Rotellar, Jose María Yun Viladomat, Sergi |
| author_facet | Ras Jiménez, Maria del Mar Ramos Polo, Raúl Francesch Manzano, Josep Corbella Santano, Miriam Morillas Climent, Herminio Jose Bazán, Núria Jiménez Marrero, Santiago Garcimartín Cerezo, Paloma Yun Viladomat, Sergi Moliner Borja, Pedro Torres Cardús, Blanca Verdú Rotellar, Jose María Diez Lopez, Carles González Costello, José García Romero, Elena Frutos Seminario, Fernando de Triguero Llonch, Laura Enjuanes, Cristina Tajes Orduña, Marta Comín Colet, Josep |
| author_role | author |
| collection | Recercat. Dipósit de la Recerca de Catalunya |
| description | The soluble transferrin receptor (sTfR) is a marker of tissue iron status, which could indicate an increased iron demand at the tissue level. The impact of sTfR levels on functional capacity and quality of life (QoL) in non-anemic heart failure (HF) patients with otherwise normal systemic iron status has not been evaluated. We conducted an observational, prospective, cohort study of 1236 patients with chronic HF. We selected patients with normal hemoglobin levels and normal systemic iron status. Tissue iron deficiency (ID) was defined as levels of sTfR > 75th percentile (1.63 mg per L). The primary endpoints were the distance walked in the 6 min walking test (6MWT) and the overall summary score (OSS) of the Minnesota Living with Heart Failure Questionnaire (MLHFQ). The final study cohort consisted of 215 patients. Overall QoL was significantly worse (51 +/- 27 vs. 39 +/- 20, p-value = 0.006, respectively), and the 6 MWT distance was significantly worse in patients with tissue ID when compared to patients without tissue ID (206 +/- 179 m vs. 314 +/- 155, p-value < 0.0001, respectively). Higher sTfR levels, indicating increased iron demand, were associated with a shorter distance in the 6 MWT (standardized beta = -0.249, p < 0.001) and a higher MLHFQ OSS (standardized fi = 0.183, p-value = 0.008). In this study, we show that in patients with normal systemic iron parameters, higher levels of sTfR are strongly associated with an impaired submaximal exercise capacity and with worse QoL. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_8a0d5bf9ea3a8033dd99c0a9a8dfd3ff |
| institution | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| instname_str | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:recercat.cat:2445/207858 |
| publishDate | 2023 |
| publishDateSort | 2023 |
| publisher | MDPI AG |
| publisherStr | MDPI AG |
| reponame_str | Recercat. Dipósit de la Recerca de Catalunya |
| spelling | Soluble Transferrin Receptor as Iron Deficiency Biomarker: Impact on Exercise Capacity in Heart Failure Patients Ras Jiménez, Maria del Mar Ramos Polo, Raúl Francesch Manzano, Josep Corbella Santano, Miriam Morillas Climent, Herminio Jose Bazán, Núria Jiménez Marrero, Santiago Garcimartín Cerezo, Paloma Yun Viladomat, Sergi Moliner Borja, Pedro Torres Cardús, Blanca Verdú Rotellar, Jose María Diez Lopez, Carles González Costello, José García Romero, Elena Frutos Seminario, Fernando de Triguero Llonch, Laura Enjuanes, Cristina Tajes Orduña, Marta Comín Colet, Josep Dèficit de ferro Marcadors bioquímics Iron deficiency diseases Biochemical markers The soluble transferrin receptor (sTfR) is a marker of tissue iron status, which could indicate an increased iron demand at the tissue level. The impact of sTfR levels on functional capacity and quality of life (QoL) in non-anemic heart failure (HF) patients with otherwise normal systemic iron status has not been evaluated. We conducted an observational, prospective, cohort study of 1236 patients with chronic HF. We selected patients with normal hemoglobin levels and normal systemic iron status. Tissue iron deficiency (ID) was defined as levels of sTfR > 75th percentile (1.63 mg per L). The primary endpoints were the distance walked in the 6 min walking test (6MWT) and the overall summary score (OSS) of the Minnesota Living with Heart Failure Questionnaire (MLHFQ). The final study cohort consisted of 215 patients. Overall QoL was significantly worse (51 +/- 27 vs. 39 +/- 20, p-value = 0.006, respectively), and the 6 MWT distance was significantly worse in patients with tissue ID when compared to patients without tissue ID (206 +/- 179 m vs. 314 +/- 155, p-value < 0.0001, respectively). Higher sTfR levels, indicating increased iron demand, were associated with a shorter distance in the 6 MWT (standardized beta = -0.249, p < 0.001) and a higher MLHFQ OSS (standardized fi = 0.183, p-value = 0.008). In this study, we show that in patients with normal systemic iron parameters, higher levels of sTfR are strongly associated with an impaired submaximal exercise capacity and with worse QoL. MDPI AG https://hdl.handle.net/2445/207858 |
| spellingShingle | Soluble Transferrin Receptor as Iron Deficiency Biomarker: Impact on Exercise Capacity in Heart Failure Patients Ras Jiménez, Maria del Mar Dèficit de ferro Marcadors bioquímics Iron deficiency diseases Biochemical markers |
| status_str | publishedVersion |
| title | Soluble Transferrin Receptor as Iron Deficiency Biomarker: Impact on Exercise Capacity in Heart Failure Patients |
| title_full | Soluble Transferrin Receptor as Iron Deficiency Biomarker: Impact on Exercise Capacity in Heart Failure Patients |
| title_fullStr | Soluble Transferrin Receptor as Iron Deficiency Biomarker: Impact on Exercise Capacity in Heart Failure Patients |
| title_full_unstemmed | Soluble Transferrin Receptor as Iron Deficiency Biomarker: Impact on Exercise Capacity in Heart Failure Patients |
| title_short | Soluble Transferrin Receptor as Iron Deficiency Biomarker: Impact on Exercise Capacity in Heart Failure Patients |
| title_sort | Soluble Transferrin Receptor as Iron Deficiency Biomarker: Impact on Exercise Capacity in Heart Failure Patients |
| topic | Dèficit de ferro Marcadors bioquímics Iron deficiency diseases Biochemical markers |
| topic_facet | Dèficit de ferro Marcadors bioquímics Iron deficiency diseases Biochemical markers |
| url | https://hdl.handle.net/2445/207858 |