Sleep Problems Are Related to a Worse Quality of Life and a Greater Non-Motor Symptoms Burden in Parkinson's Disease

Introduction: The aim of the present study was to examine the frequency of self-reported sleep problems and their associated factors in a large cohort of PD patients. Methods: PD patients and controls, recruited from 35 centers of Spain from the COPPADIS cohort were included in this cross-sectional...

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Authors: Santos-Garcia, D; Castro, ES; Fonticoba, TD; Panceiras, MJF; Enriquez, JGM; Gonzalez, JMP; Bartolome, CC; Planellas, LL; Caldentey, JG; Caballol, N; Legarda, I; Lopez, IC; Manzanares, LL; Rivera, MAA; Catalan, MJ; Nogueira, V; Borrue, C; Sauco, MA; Vela, L; Cubo, E; Castrillo, JCM; Alonso, PS; Losada, MGA; Ariztegui, NL; Gaston, MI; Kulisevsky, J; Pagonabarraga, J; Seijo, M; Martinez, JR; Valero, C; Kurtis, M; Ardura, JG; Prieto, C; Mir, P; Martinez-Martin, P
Format: Article
Status:Published version
Publication date:2021
Country:España
Institution:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repository:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p9086
Online Access:https://fisabio.portalinvestigacion.com/publicaciones/9086
Access Level:Open access
Keyword:non-motor symptoms
Parkinson's disease
Parkinson's disease sleep scale
quality of life
sleep
Summary:Introduction: The aim of the present study was to examine the frequency of self-reported sleep problems and their associated factors in a large cohort of PD patients. Methods: PD patients and controls, recruited from 35 centers of Spain from the COPPADIS cohort were included in this cross-sectional study. Sleep problems were assessed by the Spanish version of the Parkinson's disease Sleep Scale version 1 (PDSS-1). An overall score below 82 or a score below 5 on at least 1 item was defined as sleep problems. Results: The frequency of sleep problems was nearly double in PD patients compared to controls: 65.8% (448/681) vs 33.5% (65/206) (p < 0.0001). Mean total PDSS score was lower in PD patients than controls: 114.9 +/- 28.8 vs 132.8 +/- 16.3 (p < 0.0001). Quality of life (QoL) was worse in PD patients with sleep problems compared to those without: PDQ-39SI, 19.3 +/- 14 vs 13 +/- 11.6 (p < 0.0001); EUROHIS-QoL8, 3.7 +/- 0.5 vs 3.9 +/- 0.5 (p < 0.0001). Non-motor symptoms burden (NMSS; OR = 1.029; 95%CI 1.015-1.043; p < 0.0001) and impulse control behaviors (QUIP-RS; OR = 1.054; 95%CI 1.009-1.101; p = 0.018) were associated with sleep problems after adjustment for age, gender, disease duration, daily equivalent levodopa dose, H&Y, UPDRS-III, UPDRS-IV, PD-CRS, BDI-II, NPI, VAS-Pain, VAFS, FOGQ, and total number of non-antiparkinsonian treatments. Conclusion: Sleep problems were frequent in PD patients and were related to both a worse QoL and a greater non-motor symptoms burden in PD. These findings call for increased awareness of sleep problems in PD patients.

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