Methylation regulation of Antiviral host factors, Interferon Stimulated Genes (ISGs) and T-cell responses associated with natural HIV control
GWAS, immune analyses and biomarker screenings have identified host factors associated with in vivo HIV-1 control. However, there is a gap in the knowledge about the mechanisms that regulate the expression of such host factors. Here, we aimed to assess DNA methylation impact on host genome in natura...
| Autores: | ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; |
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| Tipo de documento: | Artículo |
| Fecha de publicación: | 2020 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Lenguaje: | Inglés |
| OAI Identifier: | oai:ddd.uab.cat:236577 |
| Acceso en línea: | https://ddd.uab.cat/record/236577 https://dx.doi.org/urn:doi:10.1371/JOURNAL.PPAT.1008678 |
| Nivel de acceso: | Acceso abierto |
| Palabra clave: | Antiviral Agents Biomarkers CD4-Positive T-Lymphocytes DNA Methylation Epigenesis, Genetic Female HIV Infections HIV-1 Host-Pathogen Interactions Humans Interferon Regulatory Factors Interferons Male T-Lymphocytes, Helper-Inducer Viral Load Virus Replication |
| Sumario: | GWAS, immune analyses and biomarker screenings have identified host factors associated with in vivo HIV-1 control. However, there is a gap in the knowledge about the mechanisms that regulate the expression of such host factors. Here, we aimed to assess DNA methylation impact on host genome in natural HIV-1 control. To this end, whole DNA methylome in 70 untreated HIV-1 infected individuals with either high (. |
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