Functional Gallic Acid-Based Dendrimers as Synthetic Nanotools to Remodel Amyloid-β-42 into Noncytotoxic Forms
The self-assembly of amyloid-β (Aβ) generates cytotoxic oligomers linked to the onset and progression of Alzheimer’s disease (AD). As many fundamental molecular pathways that control Aβ aggregation are yet to be unraveled, an important strategy to control Aβ cytotoxicity is the development of bioact...
| Autores: | ; ; ; ; ; |
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| Tipo de documento: | Artículo |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Universidad de Santiago de Compostela (USC) |
| Repositorio: | Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela |
| Lenguaje: | Inglés |
| OAI Identifier: | oai:minerva.usc.gal:10347/28892 |
| Acceso en línea: | http://hdl.handle.net/10347/28892 |
| Nivel de acceso: | Acceso abierto |
| _version_ | 1878735907000942592 |
|---|---|
| author | Rodrigues Araújo, Ana Rita |
| author2 | Correa Chinea, Juan Francisco Domínguez Arca, Vicente Reis, Rui L. Fernández Megía, Eduardo Rodrigues Pires, Ricardo Alexandre |
| author2_role | author author author author author |
| author_browse | Correa Chinea, Juan Francisco Domínguez Arca, Vicente Fernández Megía, Eduardo Reis, Rui L. Rodrigues Araújo, Ana Rita Rodrigues Pires, Ricardo Alexandre |
| author_facet | Rodrigues Araújo, Ana Rita Correa Chinea, Juan Francisco Domínguez Arca, Vicente Reis, Rui L. Fernández Megía, Eduardo Rodrigues Pires, Ricardo Alexandre |
| author_role | author |
| collection | Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela |
| description | The self-assembly of amyloid-β (Aβ) generates cytotoxic oligomers linked to the onset and progression of Alzheimer’s disease (AD). As many fundamental molecular pathways that control Aβ aggregation are yet to be unraveled, an important strategy to control Aβ cytotoxicity is the development of bioactive synthetic nanotools capable of interacting with the heterogeneous ensemble of Aβ species and remodel them into noncytotoxic forms. Herein, the synthesis of nanosized, functional gallic acid (Ga)-based dendrimers with a precise number of Ga at their surface is described. It is shown that these Ga-terminated dendrimers interact by H-bonding with monomeric/oligomeric Aβ species at their Glu, Ala, and Asp residues, promoting their remodeling into noncytotoxic aggregates in a process controlled by the Ga units. The multivalent presentation of Ga on the dendrimer surface enhances their ability to interact with Aβ, inhibiting the primary and secondary nucleation of Aβ fibrillization and disrupting the Aβ preformed fibrils |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_8559d623701ef6407d5f7ed04e8aaf76 |
| institution | Universidad de Santiago de Compostela (USC) |
| instname_str | Universidad de Santiago de Compostela (USC) |
| language | eng |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:minerva.usc.gal:10347/28892 |
| publishDate | 2021 |
| publishDateSort | 2021 |
| publisher | ACS Publications |
| publisherStr | ACS Publications |
| reponame_str | Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela |
| spelling | Functional Gallic Acid-Based Dendrimers as Synthetic Nanotools to Remodel Amyloid-β-42 into Noncytotoxic Forms Rodrigues Araújo, Ana Rita Correa Chinea, Juan Francisco Domínguez Arca, Vicente Reis, Rui L. Fernández Megía, Eduardo Rodrigues Pires, Ricardo Alexandre The self-assembly of amyloid-β (Aβ) generates cytotoxic oligomers linked to the onset and progression of Alzheimer’s disease (AD). As many fundamental molecular pathways that control Aβ aggregation are yet to be unraveled, an important strategy to control Aβ cytotoxicity is the development of bioactive synthetic nanotools capable of interacting with the heterogeneous ensemble of Aβ species and remodel them into noncytotoxic forms. Herein, the synthesis of nanosized, functional gallic acid (Ga)-based dendrimers with a precise number of Ga at their surface is described. It is shown that these Ga-terminated dendrimers interact by H-bonding with monomeric/oligomeric Aβ species at their Glu, Ala, and Asp residues, promoting their remodeling into noncytotoxic aggregates in a process controlled by the Ga units. The multivalent presentation of Ga on the dendrimer surface enhances their ability to interact with Aβ, inhibiting the primary and secondary nucleation of Aβ fibrillization and disrupting the Aβ preformed fibrils ACS Publications http://hdl.handle.net/10347/28892 |
| spellingShingle | Functional Gallic Acid-Based Dendrimers as Synthetic Nanotools to Remodel Amyloid-β-42 into Noncytotoxic Forms Rodrigues Araújo, Ana Rita |
| title | Functional Gallic Acid-Based Dendrimers as Synthetic Nanotools to Remodel Amyloid-β-42 into Noncytotoxic Forms |
| title_full | Functional Gallic Acid-Based Dendrimers as Synthetic Nanotools to Remodel Amyloid-β-42 into Noncytotoxic Forms |
| title_fullStr | Functional Gallic Acid-Based Dendrimers as Synthetic Nanotools to Remodel Amyloid-β-42 into Noncytotoxic Forms |
| title_full_unstemmed | Functional Gallic Acid-Based Dendrimers as Synthetic Nanotools to Remodel Amyloid-β-42 into Noncytotoxic Forms |
| title_short | Functional Gallic Acid-Based Dendrimers as Synthetic Nanotools to Remodel Amyloid-β-42 into Noncytotoxic Forms |
| title_sort | Functional Gallic Acid-Based Dendrimers as Synthetic Nanotools to Remodel Amyloid-β-42 into Noncytotoxic Forms |
| url | http://hdl.handle.net/10347/28892 |