Predicting Gastric Cancer Molecular Subtypes from Gene Expression Data
(This article belongs to the Proceedings of 3rd XoveTIC Conference)
| Authors: | ; ; ; ; |
|---|---|
| Format: | Article |
| Publication date: | 2020 |
| Country: | España |
| Institution: | Universitat Politècnica de Catalunya (UPC) |
| Repository: | UPCommons. Portal del coneixement obert de la UPC |
| Language: | English |
| OAI Identifier: | oai:upcommons.upc.edu:2117/329190 |
| Online Access: | https://hdl.handle.net/2117/329190 https://dx.doi.org/10.3390/proceedings2020054059 |
| Access Level: | Open access |
| Keyword: | Cancer -- Molecular aspects Stomach--Cancer Gene expression Gastric cancer Disease classification Machine learning Càncer -- Aspectes moleculars Àrees temàtiques de la UPC::Informàtica::Aplicacions de la informàtica::Bioinformàtica |
| _version_ | 1878735896035983360 |
|---|---|
| author | Moreno, Marta |
| author2 | Sousa, Abel Melé, Marta|||0000-0001-8874-6453 Oliveira, Rui Ferreira, Pedro G. |
| author2_role | author author author author |
| author_browse | Ferreira, Pedro G. Melé, Marta|||0000-0001-8874-6453 Moreno, Marta Oliveira, Rui Sousa, Abel |
| author_facet | Moreno, Marta Sousa, Abel Melé, Marta|||0000-0001-8874-6453 Oliveira, Rui Ferreira, Pedro G. |
| author_role | author |
| collection | UPCommons. Portal del coneixement obert de la UPC |
| description | (This article belongs to the Proceedings of 3rd XoveTIC Conference) |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_852fa8aa3cd4e17b991cfda96a43374e |
| institution | Universitat Politècnica de Catalunya (UPC) |
| instname_str | Universitat Politècnica de Catalunya (UPC) |
| language | eng |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:upcommons.upc.edu:2117/329190 |
| publishDate | 2020 |
| publishDateSort | 2020 |
| publisher | MDPI |
| publisherStr | MDPI |
| reponame_str | UPCommons. Portal del coneixement obert de la UPC |
| spelling | Predicting Gastric Cancer Molecular Subtypes from Gene Expression Data Proceedings, 2020, XoveTIC 2020 Moreno, Marta Sousa, Abel Melé, Marta|||0000-0001-8874-6453 Oliveira, Rui Ferreira, Pedro G. Cancer -- Molecular aspects Stomach--Cancer Gene expression Gastric cancer Disease classification Machine learning Càncer -- Aspectes moleculars Àrees temàtiques de la UPC::Informàtica::Aplicacions de la informàtica::Bioinformàtica (This article belongs to the Proceedings of 3rd XoveTIC Conference) Stomach cancer is a complex disease and one of the leading causes of cancer mortality in the world. With the view to improve patient diagnosis and prognosis, it has been stratified into four molecular subtypes. In this work, we compare the results of multiple machine learning algorithms for the prediction of stomach cancer molecular subtypes from gene expression data. Moreover, we show the importance of decorrelating clinical and technical covariates. This work was supported by the FCT (Fundação para a Ciência e a Tecnologia) research grant Ph.D. Studentship SFRH/BD/145707/2019 and the research grant IF/01127/2014, funded in the scope of the FCT Investigator Exploratory Project: “Understanding the impact of acquired and germline genetic variants in the complexity of gastric cancer”; GenomePT project (reference 22184): “National Laboratory for Genome Sequencing and Analysis”; QREN L3 project (reference NORTE-01-0145-FEDER-000029): “Mapping genetic and phenotypic heterogeneity in HER2 positive cancers to anticipate and counteract resistance phenotypes”. Peer Reviewed MDPI https://hdl.handle.net/2117/329190 https://dx.doi.org/10.3390/proceedings2020054059 |
| spellingShingle | Predicting Gastric Cancer Molecular Subtypes from Gene Expression Data Moreno, Marta Cancer -- Molecular aspects Stomach--Cancer Gene expression Gastric cancer Disease classification Machine learning Càncer -- Aspectes moleculars Àrees temàtiques de la UPC::Informàtica::Aplicacions de la informàtica::Bioinformàtica |
| title | Predicting Gastric Cancer Molecular Subtypes from Gene Expression Data |
| title_full | Predicting Gastric Cancer Molecular Subtypes from Gene Expression Data |
| title_fullStr | Predicting Gastric Cancer Molecular Subtypes from Gene Expression Data |
| title_full_unstemmed | Predicting Gastric Cancer Molecular Subtypes from Gene Expression Data |
| title_short | Predicting Gastric Cancer Molecular Subtypes from Gene Expression Data |
| title_sort | Predicting Gastric Cancer Molecular Subtypes from Gene Expression Data |
| topic | Cancer -- Molecular aspects Stomach--Cancer Gene expression Gastric cancer Disease classification Machine learning Càncer -- Aspectes moleculars Àrees temàtiques de la UPC::Informàtica::Aplicacions de la informàtica::Bioinformàtica |
| topic_facet | Cancer -- Molecular aspects Stomach--Cancer Gene expression Gastric cancer Disease classification Machine learning Càncer -- Aspectes moleculars Àrees temàtiques de la UPC::Informàtica::Aplicacions de la informàtica::Bioinformàtica |
| url | https://hdl.handle.net/2117/329190 https://dx.doi.org/10.3390/proceedings2020054059 |