Cellulose‑in‑cellulose 3D‑printed bioaerogels for bone tissue engineering
Nanostructured scaffolds based on cellulose with advanced performances and personalized morphologies for bone tissue engineering are under technological development. 3D-printing and supercritical carbon dioxide (scCO2) technologies are innovative processing strategies that, when combined, allow the...
| Authors: | ; ; ; ; ; ; ; |
|---|---|
| Format: | Article |
| Publication date: | 2023 |
| Country: | España |
| Institution: | Universidad de Santiago de Compostela (USC) |
| Repository: | Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela |
| Language: | English |
| OAI Identifier: | oai:minerva.usc.gal:10347/45768 |
| Online Access: | https://hdl.handle.net/10347/45768 |
| Access Level: | Open access |
| Keyword: | Aerogeles |
| _version_ | 1878735880632401921 |
|---|---|
| author | Iglesias-Mejuto, Ana |
| author2 | Malandain, Nanthilde Ferreira-Gonçalves, Tânia Ardao Palacios, Inés Pinto Reis, Catarina Laromaine, Anna Roig, Anna García González, Carlos A. |
| author2_role | author author author author author author author |
| author_browse | Ardao Palacios, Inés Ferreira-Gonçalves, Tânia García González, Carlos A. Iglesias-Mejuto, Ana Laromaine, Anna Malandain, Nanthilde Pinto Reis, Catarina Roig, Anna |
| author_facet | Iglesias-Mejuto, Ana Malandain, Nanthilde Ferreira-Gonçalves, Tânia Ardao Palacios, Inés Pinto Reis, Catarina Laromaine, Anna Roig, Anna García González, Carlos A. |
| author_role | author |
| collection | Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela |
| description | Nanostructured scaffolds based on cellulose with advanced performances and personalized morphologies for bone tissue engineering are under technological development. 3D-printing and supercritical carbon dioxide (scCO2) technologies are innovative processing strategies that, when combined, allow the precise fabrication of highly porous aerogel scaffolds. Novel sterile cellulose-in-cellulose aerogels decorated with superparamagnetic iron oxide nanoparticles (SPIONs) are synthesized in this work by an integrated technological platform based on 3D-printing and scCO2. Methylcellulose (MC) and bacterial nanocellulose (BC) are two versatile cellulosic polysaccharides with remarkable physicochemical and biological performances, whereas SPIONs are commonly used to functionalize biomaterials aimed at tissue engineering. Aerogels with hierarchical porosity and high structural resolution were obtained according to nitrogen adsorption–desorption analysis, confocal, scanning and transmission microscopies (SEM and TEM). The magnetic properties of SPIONsdoped aerogels confirmed the correct functionalization of the nanostructures. Finally, NIH/3T3 fibroblast cell viability, hemocompatibility with human blood and safety tests (in ovo with HET-CAM and in vivo with Artemia salina) indicate the biocompatibility of the cellulose-in-cellulose aerogels. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_84ea55dae8a09de3d9003403cd2a2a49 |
| institution | Universidad de Santiago de Compostela (USC) |
| instname_str | Universidad de Santiago de Compostela (USC) |
| language | eng |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:minerva.usc.gal:10347/45768 |
| publishDate | 2023 |
| publishDateSort | 2023 |
| publisher | Springer |
| publisherStr | Springer |
| reponame_str | Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela |
| spelling | Cellulose‑in‑cellulose 3D‑printed bioaerogels for bone tissue engineering Iglesias-Mejuto, Ana Malandain, Nanthilde Ferreira-Gonçalves, Tânia Ardao Palacios, Inés Pinto Reis, Catarina Laromaine, Anna Roig, Anna García González, Carlos A. Aerogeles Nanostructured scaffolds based on cellulose with advanced performances and personalized morphologies for bone tissue engineering are under technological development. 3D-printing and supercritical carbon dioxide (scCO2) technologies are innovative processing strategies that, when combined, allow the precise fabrication of highly porous aerogel scaffolds. Novel sterile cellulose-in-cellulose aerogels decorated with superparamagnetic iron oxide nanoparticles (SPIONs) are synthesized in this work by an integrated technological platform based on 3D-printing and scCO2. Methylcellulose (MC) and bacterial nanocellulose (BC) are two versatile cellulosic polysaccharides with remarkable physicochemical and biological performances, whereas SPIONs are commonly used to functionalize biomaterials aimed at tissue engineering. Aerogels with hierarchical porosity and high structural resolution were obtained according to nitrogen adsorption–desorption analysis, confocal, scanning and transmission microscopies (SEM and TEM). The magnetic properties of SPIONsdoped aerogels confirmed the correct functionalization of the nanostructures. Finally, NIH/3T3 fibroblast cell viability, hemocompatibility with human blood and safety tests (in ovo with HET-CAM and in vivo with Artemia salina) indicate the biocompatibility of the cellulose-in-cellulose aerogels. Springer https://hdl.handle.net/10347/45768 |
| spellingShingle | Cellulose‑in‑cellulose 3D‑printed bioaerogels for bone tissue engineering Iglesias-Mejuto, Ana Aerogeles |
| title | Cellulose‑in‑cellulose 3D‑printed bioaerogels for bone tissue engineering |
| title_full | Cellulose‑in‑cellulose 3D‑printed bioaerogels for bone tissue engineering |
| title_fullStr | Cellulose‑in‑cellulose 3D‑printed bioaerogels for bone tissue engineering |
| title_full_unstemmed | Cellulose‑in‑cellulose 3D‑printed bioaerogels for bone tissue engineering |
| title_short | Cellulose‑in‑cellulose 3D‑printed bioaerogels for bone tissue engineering |
| title_sort | Cellulose‑in‑cellulose 3D‑printed bioaerogels for bone tissue engineering |
| topic | Aerogeles |
| topic_facet | Aerogeles |
| url | https://hdl.handle.net/10347/45768 |