Catalytic asymmetric fluorination of Alkyl 1-indanone-2-carboxylates Ruled by Pybox-Eu(III) Combination
A highly enantioselective catalytic method for the synthesis of quaternary α-fluoro derivatives of 3-oxo esters is described. The reaction uses europium (III) triflate and commercially available chiral pybox-type C2-symmetric ligand. Excellent results in terms of yields and enantioselectivities were...
| Authors: | ; ; |
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| Format: | Article |
| Publication date: | 2019 |
| Country: | España |
| Institution: | Universitat Autònoma de Barcelona |
| Repository: | Dipòsit Digital de Documents de la UAB |
| Language: | English |
| OAI Identifier: | oai:ddd.uab.cat:223203 |
| Online Access: | https://ddd.uab.cat/record/223203 https://dx.doi.org/urn:doi:10.3390/molecules24061141 |
| Access Level: | Open access |
| Keyword: | Europium Fluorination Enantioselectivity Pybox Keto ester |
| _version_ | 1878735821202259968 |
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| author | Granados, Albert|||0000-0002-5362-5966 |
| author2 | Sarró Grane, Pau|||0000-0002-0957-2481 Vallribera, Adelina|||0000-0002-6452-4589 |
| author2_role | author author |
| author_browse | Granados, Albert|||0000-0002-5362-5966 Sarró Grane, Pau|||0000-0002-0957-2481 Vallribera, Adelina|||0000-0002-6452-4589 |
| author_facet | Granados, Albert|||0000-0002-5362-5966 Sarró Grane, Pau|||0000-0002-0957-2481 Vallribera, Adelina|||0000-0002-6452-4589 |
| author_role | author |
| collection | Dipòsit Digital de Documents de la UAB |
| description | A highly enantioselective catalytic method for the synthesis of quaternary α-fluoro derivatives of 3-oxo esters is described. The reaction uses europium (III) triflate and commercially available chiral pybox-type C2-symmetric ligand. Excellent results in terms of yields and enantioselectivities were assured using the electrophilic NFSI reagent under mild reaction conditions. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_83edd19f3674366e7b5abaefae8e8a4d |
| institution | Universitat Autònoma de Barcelona |
| instname_str | Universitat Autònoma de Barcelona |
| language | eng |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:ddd.uab.cat:223203 |
| publishDate | 2019 |
| publishDateSort | 2019 |
| reponame_str | Dipòsit Digital de Documents de la UAB |
| spelling | Catalytic asymmetric fluorination of Alkyl 1-indanone-2-carboxylates Ruled by Pybox-Eu(III) Combination Granados, Albert|||0000-0002-5362-5966 Sarró Grane, Pau|||0000-0002-0957-2481 Vallribera, Adelina|||0000-0002-6452-4589 Europium Fluorination Enantioselectivity Pybox Keto ester A highly enantioselective catalytic method for the synthesis of quaternary α-fluoro derivatives of 3-oxo esters is described. The reaction uses europium (III) triflate and commercially available chiral pybox-type C2-symmetric ligand. Excellent results in terms of yields and enantioselectivities were assured using the electrophilic NFSI reagent under mild reaction conditions. https://ddd.uab.cat/record/223203 https://dx.doi.org/urn:doi:10.3390/molecules24061141 |
| spellingShingle | Catalytic asymmetric fluorination of Alkyl 1-indanone-2-carboxylates Ruled by Pybox-Eu(III) Combination Granados, Albert|||0000-0002-5362-5966 Europium Fluorination Enantioselectivity Pybox Keto ester |
| title | Catalytic asymmetric fluorination of Alkyl 1-indanone-2-carboxylates Ruled by Pybox-Eu(III) Combination |
| title_full | Catalytic asymmetric fluorination of Alkyl 1-indanone-2-carboxylates Ruled by Pybox-Eu(III) Combination |
| title_fullStr | Catalytic asymmetric fluorination of Alkyl 1-indanone-2-carboxylates Ruled by Pybox-Eu(III) Combination |
| title_full_unstemmed | Catalytic asymmetric fluorination of Alkyl 1-indanone-2-carboxylates Ruled by Pybox-Eu(III) Combination |
| title_short | Catalytic asymmetric fluorination of Alkyl 1-indanone-2-carboxylates Ruled by Pybox-Eu(III) Combination |
| title_sort | Catalytic asymmetric fluorination of Alkyl 1-indanone-2-carboxylates Ruled by Pybox-Eu(III) Combination |
| topic | Europium Fluorination Enantioselectivity Pybox Keto ester |
| topic_facet | Europium Fluorination Enantioselectivity Pybox Keto ester |
| url | https://ddd.uab.cat/record/223203 https://dx.doi.org/urn:doi:10.3390/molecules24061141 |