Evaluation of the Geriatric Nutritional Risk Index in predicting mortality in older patients with COVID-19 in the AgeBru cohort
Objective: To determine whether the Geriatric Nutritional Risk Index (GNRI) on hospital admission was associated to an increased 14-day and 12-month mortality-risk in older inpatients with COVID-19. Methods: Cohort study of consecutive inpatients admitted with COVID-19 in a university hospital (20/0...
| Autores: | ; ; ; ; ; ; ; ; ; |
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| Tipo de documento: | Artículo |
| Estado: | Accepted version |
| Fecha de publicación: | 2023 |
| País: | España |
| Institución: | Universitat Pompeu Fabra |
| Repositorio: | Repositorio Digital de la UPF |
| OAI Identifier: | oai:repositori.upf.edu:10230/60146 |
| Acceso en línea: | http://hdl.handle.net/10230/60146 http://dx.doi.org/10.1016/j.clnesp.2023.06.025 |
| Nivel de acceso: | Acceso abierto |
| Palabra clave: | COVID-19 GNRI Inflammation Malnutrition risk screening Mortality Older people |
| _version_ | 1878735673597362176 |
|---|---|
| author | De Meester, Dorien |
| author2 | Goossens, Mathijs Marco Navarro, Ester Claessens, Marie Gautier, Jennifer Annweiler, Cédric Lieten, Siddhartha Benoit, Florence Surquin, Murielle Sánchez-Rodríguez, Dolores |
| author2_role | author author author author author author author author author |
| author_browse | Annweiler, Cédric Benoit, Florence Claessens, Marie De Meester, Dorien Gautier, Jennifer Goossens, Mathijs Lieten, Siddhartha Marco Navarro, Ester Surquin, Murielle Sánchez-Rodríguez, Dolores |
| author_facet | De Meester, Dorien Goossens, Mathijs Marco Navarro, Ester Claessens, Marie Gautier, Jennifer Annweiler, Cédric Lieten, Siddhartha Benoit, Florence Surquin, Murielle Sánchez-Rodríguez, Dolores |
| author_role | author |
| collection | Repositorio Digital de la UPF |
| description | Objective: To determine whether the Geriatric Nutritional Risk Index (GNRI) on hospital admission was associated to an increased 14-day and 12-month mortality-risk in older inpatients with COVID-19. Methods: Cohort study of consecutive inpatients admitted with COVID-19 in a university hospital (20/03/2020-11/05/2021). Inclusion criteria: age over 65 years and positive polymerase chain reaction test. Exclusion criteria: missing data for weight, height, and/or albumin, hospital-acquired COVID-19, or patients transferred to other health facilities. Outcome: all-cause mortality at 14-day and 12-month follow-up. GNRI [1.489 × albumin (g/L)] + [41.7 (weight/ideal body weight)] was assessed at admission; scores ≤98 indicated risk of malnutrition. Cox-proportional hazards models assessed the association between the admission GNRI and 14-day and 12-month mortality-risk, after adjusting by demographic and clinical variables, including inflammation (C-reactive protein). Results: Of the 570 eligible patients, 224 (mean age 78 years; 52.2% women) met inclusion criteria and 151 (67.4%) were classified at risk of malnutrition. Twenty patients died during the 14-day and 42 during the 12-month follow-up. The risk of 14-day mortality was nearly 10 times higher in patients with GNRI scores ≤98 (HR = 9.6 [95%CI 1.3-71.6], P = 0.028); this association was marginally significant in the adjusted model (HR = 6.73 [95%CI 0.89-51.11], P = 0.065)]. No association between GNRI and the 12-month mortality-risk was found. Conclusions: The GNRI may play a role in the short-term prognosis of older inpatients with COVID-19. Further studies are required to confirm the short-term predictive validity of the GNRI within this population (Clinicaltrials.gov_NCT05276752). |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_815bec6d0b4e30e8edc9eb95134c8c21 |
| institution | Universitat Pompeu Fabra |
| instname_str | Universitat Pompeu Fabra |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:repositori.upf.edu:10230/60146 |
| publishDate | 2023 |
| publishDateSort | 2023 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| reponame_str | Repositorio Digital de la UPF |
| spelling | Evaluation of the Geriatric Nutritional Risk Index in predicting mortality in older patients with COVID-19 in the AgeBru cohort De Meester, Dorien Goossens, Mathijs Marco Navarro, Ester Claessens, Marie Gautier, Jennifer Annweiler, Cédric Lieten, Siddhartha Benoit, Florence Surquin, Murielle Sánchez-Rodríguez, Dolores COVID-19 GNRI Inflammation Malnutrition risk screening Mortality Older people Objective: To determine whether the Geriatric Nutritional Risk Index (GNRI) on hospital admission was associated to an increased 14-day and 12-month mortality-risk in older inpatients with COVID-19. Methods: Cohort study of consecutive inpatients admitted with COVID-19 in a university hospital (20/03/2020-11/05/2021). Inclusion criteria: age over 65 years and positive polymerase chain reaction test. Exclusion criteria: missing data for weight, height, and/or albumin, hospital-acquired COVID-19, or patients transferred to other health facilities. Outcome: all-cause mortality at 14-day and 12-month follow-up. GNRI [1.489 × albumin (g/L)] + [41.7 (weight/ideal body weight)] was assessed at admission; scores ≤98 indicated risk of malnutrition. Cox-proportional hazards models assessed the association between the admission GNRI and 14-day and 12-month mortality-risk, after adjusting by demographic and clinical variables, including inflammation (C-reactive protein). Results: Of the 570 eligible patients, 224 (mean age 78 years; 52.2% women) met inclusion criteria and 151 (67.4%) were classified at risk of malnutrition. Twenty patients died during the 14-day and 42 during the 12-month follow-up. The risk of 14-day mortality was nearly 10 times higher in patients with GNRI scores ≤98 (HR = 9.6 [95%CI 1.3-71.6], P = 0.028); this association was marginally significant in the adjusted model (HR = 6.73 [95%CI 0.89-51.11], P = 0.065)]. No association between GNRI and the 12-month mortality-risk was found. Conclusions: The GNRI may play a role in the short-term prognosis of older inpatients with COVID-19. Further studies are required to confirm the short-term predictive validity of the GNRI within this population (Clinicaltrials.gov_NCT05276752). Elsevier http://hdl.handle.net/10230/60146 http://dx.doi.org/10.1016/j.clnesp.2023.06.025 |
| spellingShingle | Evaluation of the Geriatric Nutritional Risk Index in predicting mortality in older patients with COVID-19 in the AgeBru cohort De Meester, Dorien COVID-19 GNRI Inflammation Malnutrition risk screening Mortality Older people |
| status_str | acceptedVersion |
| title | Evaluation of the Geriatric Nutritional Risk Index in predicting mortality in older patients with COVID-19 in the AgeBru cohort |
| title_full | Evaluation of the Geriatric Nutritional Risk Index in predicting mortality in older patients with COVID-19 in the AgeBru cohort |
| title_fullStr | Evaluation of the Geriatric Nutritional Risk Index in predicting mortality in older patients with COVID-19 in the AgeBru cohort |
| title_full_unstemmed | Evaluation of the Geriatric Nutritional Risk Index in predicting mortality in older patients with COVID-19 in the AgeBru cohort |
| title_short | Evaluation of the Geriatric Nutritional Risk Index in predicting mortality in older patients with COVID-19 in the AgeBru cohort |
| title_sort | Evaluation of the Geriatric Nutritional Risk Index in predicting mortality in older patients with COVID-19 in the AgeBru cohort |
| topic | COVID-19 GNRI Inflammation Malnutrition risk screening Mortality Older people |
| topic_facet | COVID-19 GNRI Inflammation Malnutrition risk screening Mortality Older people |
| url | http://hdl.handle.net/10230/60146 http://dx.doi.org/10.1016/j.clnesp.2023.06.025 |