Impact of COVID-19 infection on cognition and its association with neurological symptoms
Objective: To characterize the cognitive profile following COVID-19 infection and its possible association to clinical symptoms, emotional disturbance, biomarkers, and disease severity. Methods: This was a single-center cross-sectional cohort study. Subjects between 20- and 60-year old with confirme...
| Authors: | ; ; ; ; |
|---|---|
| Format: | Article |
| Status: | Published version |
| Publication date: | 2023 |
| Country: | España |
| Institution: | Universitat Pompeu Fabra |
| Repository: | Repositorio Digital de la UPF |
| OAI Identifier: | oai:repositori.upf.edu:10230/60200 |
| Online Access: | http://hdl.handle.net/10230/60200 http://dx.doi.org/10.1002/brb3.2902 |
| Access Level: | Open access |
| Keyword: | COVID-19 Cognitive impairment Neurologic symptoms Neuropsychology |
| _version_ | 1878735597798948864 |
|---|---|
| author | Almeria, M. |
| author2 | Cejudo, Juan Carlos Sanz-Santos, José Deus, Joan Krupinski, Jerzy |
| author2_role | author author author author |
| author_browse | Almeria, M. Cejudo, Juan Carlos Deus, Joan Krupinski, Jerzy Sanz-Santos, José |
| author_facet | Almeria, M. Cejudo, Juan Carlos Sanz-Santos, José Deus, Joan Krupinski, Jerzy |
| author_role | author |
| collection | Repositorio Digital de la UPF |
| description | Objective: To characterize the cognitive profile following COVID-19 infection and its possible association to clinical symptoms, emotional disturbance, biomarkers, and disease severity. Methods: This was a single-center cross-sectional cohort study. Subjects between 20- and 60-year old with confirmed COVID-19 infection were included. Evaluation was performed between April 2020 and July 2021. Patients with previous cognitive impairment and other neurological or severe psychiatric disorders were excluded. Demographic and laboratory data were extracted from the medical records. Results: Altogether 200 patients were included, 85 subjects were female (42.3%), and mean age was 49.12 years (SD: 7.84). Patients were classified into four groups: nonhospitalized (NH, n = 21), hospitalized without intensive care unit (ICU) nor oxygen therapy (HOSP, n = 42), hospitalized without ICU but with oxygen therapy (OXY, n = 107), and ICU (ICU, n = 31) patients. NH group was younger (p = .026). No significant differences were found in any test performed attending severity of illness (p > .05). A total of 55 patients reported subjective cognitive complaints (SCC). Subjects with neurological symptoms (NS) performed worse in trail making test B (p = .013), digits backwards (p = .006), letter&numbers (p = .002), symbol digit modalities test (p = .016), and Stroop color (p = .010) tests. Conclusions: OXY patients and females referred more SCC associated with symptoms of anxiety and depression. Objective cognitive performance was unrelated to SCC. No cognitive impairment was found regarding the severity of COVID-19 infection. Results suggest that NS such as headache, anosmia, and dysgeusia during infection were a risk factor for later cognitive deficits. Tests assessing attention, processing speed, and executive function were the most sensitive in detecting cognitive changes in these patients. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_7fec8a7d1dbbfb09b6fecbee9cd6a724 |
| institution | Universitat Pompeu Fabra |
| instname_str | Universitat Pompeu Fabra |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:repositori.upf.edu:10230/60200 |
| publishDate | 2023 |
| publishDateSort | 2023 |
| publisher | Wiley |
| publisherStr | Wiley |
| reponame_str | Repositorio Digital de la UPF |
| spelling | Impact of COVID-19 infection on cognition and its association with neurological symptoms Almeria, M. Cejudo, Juan Carlos Sanz-Santos, José Deus, Joan Krupinski, Jerzy COVID-19 Cognitive impairment Neurologic symptoms Neuropsychology Objective: To characterize the cognitive profile following COVID-19 infection and its possible association to clinical symptoms, emotional disturbance, biomarkers, and disease severity. Methods: This was a single-center cross-sectional cohort study. Subjects between 20- and 60-year old with confirmed COVID-19 infection were included. Evaluation was performed between April 2020 and July 2021. Patients with previous cognitive impairment and other neurological or severe psychiatric disorders were excluded. Demographic and laboratory data were extracted from the medical records. Results: Altogether 200 patients were included, 85 subjects were female (42.3%), and mean age was 49.12 years (SD: 7.84). Patients were classified into four groups: nonhospitalized (NH, n = 21), hospitalized without intensive care unit (ICU) nor oxygen therapy (HOSP, n = 42), hospitalized without ICU but with oxygen therapy (OXY, n = 107), and ICU (ICU, n = 31) patients. NH group was younger (p = .026). No significant differences were found in any test performed attending severity of illness (p > .05). A total of 55 patients reported subjective cognitive complaints (SCC). Subjects with neurological symptoms (NS) performed worse in trail making test B (p = .013), digits backwards (p = .006), letter&numbers (p = .002), symbol digit modalities test (p = .016), and Stroop color (p = .010) tests. Conclusions: OXY patients and females referred more SCC associated with symptoms of anxiety and depression. Objective cognitive performance was unrelated to SCC. No cognitive impairment was found regarding the severity of COVID-19 infection. Results suggest that NS such as headache, anosmia, and dysgeusia during infection were a risk factor for later cognitive deficits. Tests assessing attention, processing speed, and executive function were the most sensitive in detecting cognitive changes in these patients. Wiley http://hdl.handle.net/10230/60200 http://dx.doi.org/10.1002/brb3.2902 |
| spellingShingle | Impact of COVID-19 infection on cognition and its association with neurological symptoms Almeria, M. COVID-19 Cognitive impairment Neurologic symptoms Neuropsychology |
| status_str | publishedVersion |
| title | Impact of COVID-19 infection on cognition and its association with neurological symptoms |
| title_full | Impact of COVID-19 infection on cognition and its association with neurological symptoms |
| title_fullStr | Impact of COVID-19 infection on cognition and its association with neurological symptoms |
| title_full_unstemmed | Impact of COVID-19 infection on cognition and its association with neurological symptoms |
| title_short | Impact of COVID-19 infection on cognition and its association with neurological symptoms |
| title_sort | Impact of COVID-19 infection on cognition and its association with neurological symptoms |
| topic | COVID-19 Cognitive impairment Neurologic symptoms Neuropsychology |
| topic_facet | COVID-19 Cognitive impairment Neurologic symptoms Neuropsychology |
| url | http://hdl.handle.net/10230/60200 http://dx.doi.org/10.1002/brb3.2902 |