Biomarkers for diagnosis and prediction of therapy responses in allergic diseases and asthma.
Modern health care requires a proactive and individualized response to diseases, combining precision diagnosis and personalized treatment. Accordingly, the approach to patients with allergic diseases encompasses novel developments in the area of personalized medicine, disease phenotyping and endotyp...
| Authors: | ; ; ; ; ; ; ; ; ; ; ; ; ; ; |
|---|---|
| Format: | Article |
| Publication date: | 2020 |
| Country: | España |
| Institution: | Instituto de Salud Carlos III (ISCIII) |
| Repository: | Repisalud |
| Language: | English |
| OAI Identifier: | oai:repisalud.isciii.es:20.500.12105/18129 |
| Online Access: | http://hdl.handle.net/20.500.12105/18129 |
| Access Level: | Open access |
| Keyword: | Allergen immunotherapy Allergic rhinitis Asthma phenotypes and endotypes Biomarkers Food allergy Asthma Dermatitis, Atopic Food Hypersensitivity Humans Hypersensitivity Rhinitis, Allergic |
| _version_ | 1878735537456545793 |
|---|---|
| author | Breiteneder, Heimo |
| author2 | Peng, Ya-Qi Agache, Ioana Diamant, Zuzana Eiwegger, Thomas Fokkens, Wytske J Traidl-Hoffmann, Claudia Nadeau, Kari O'Hehir, Robyn E O'Mahony, Liam Pfaar, Oliver Torres, Maria J Wang, De-Yun Zhang, Luo Akdis, Cezmi A |
| author2_role | author author author author author author author author author author author author author author |
| author_browse | Agache, Ioana Akdis, Cezmi A Breiteneder, Heimo Diamant, Zuzana Eiwegger, Thomas Fokkens, Wytske J Nadeau, Kari O'Hehir, Robyn E O'Mahony, Liam Peng, Ya-Qi Pfaar, Oliver Torres, Maria J Traidl-Hoffmann, Claudia Wang, De-Yun Zhang, Luo |
| author_facet | Breiteneder, Heimo Peng, Ya-Qi Agache, Ioana Diamant, Zuzana Eiwegger, Thomas Fokkens, Wytske J Traidl-Hoffmann, Claudia Nadeau, Kari O'Hehir, Robyn E O'Mahony, Liam Pfaar, Oliver Torres, Maria J Wang, De-Yun Zhang, Luo Akdis, Cezmi A |
| author_role | author |
| collection | Repisalud |
| description | Modern health care requires a proactive and individualized response to diseases, combining precision diagnosis and personalized treatment. Accordingly, the approach to patients with allergic diseases encompasses novel developments in the area of personalized medicine, disease phenotyping and endotyping, and the development and application of reliable biomarkers. A detailed clinical history and physical examination followed by the detection of IgE immunoreactivity against specific allergens still represents the state of the art. However, nowadays, further emphasis focuses on the optimization of diagnostic and therapeutic standards and a large number of studies have been investigating the biomarkers of allergic diseases, including asthma, atopic dermatitis, allergic rhinitis, food allergy, urticaria and anaphylaxis. Various biomarkers have been developed by omics technologies, some of which lead to a better classification of distinct phenotypes or endotypes. The introduction of biologicals to clinical practice increases the need for biomarkers for patient selection, prediction of outcomes and monitoring, to allow for an adequate choice of the duration of these costly and long-lasting therapies. Escalating healthcare costs together with questions about the efficacy of the current management of allergic diseases require further development of a biomarker-driven approach. Here, we review biomarkers in diagnosis and treatment of asthma, atopic dermatitis, allergic rhinitis, viral infections, chronic rhinosinusitis, food allergy, drug hypersensitivity and allergen immunotherapy with a special emphasis on specific IgE, the microbiome and the epithelial barrier. In addition, EAACI guidelines on biologicals are discussed within the perspective of biomarkers. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_7eaf0f8f347312bb8ea240c0c5699a4e |
| institution | Instituto de Salud Carlos III (ISCIII) |
| instname_str | Instituto de Salud Carlos III (ISCIII) |
| language | eng |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:repisalud.isciii.es:20.500.12105/18129 |
| publishDate | 2020 |
| publishDateSort | 2020 |
| reponame_str | Repisalud |
| spelling | Biomarkers for diagnosis and prediction of therapy responses in allergic diseases and asthma. Breiteneder, Heimo Peng, Ya-Qi Agache, Ioana Diamant, Zuzana Eiwegger, Thomas Fokkens, Wytske J Traidl-Hoffmann, Claudia Nadeau, Kari O'Hehir, Robyn E O'Mahony, Liam Pfaar, Oliver Torres, Maria J Wang, De-Yun Zhang, Luo Akdis, Cezmi A Allergen immunotherapy Allergic rhinitis Asthma phenotypes and endotypes Biomarkers Food allergy Asthma Dermatitis, Atopic Food Hypersensitivity Humans Hypersensitivity Rhinitis, Allergic Modern health care requires a proactive and individualized response to diseases, combining precision diagnosis and personalized treatment. Accordingly, the approach to patients with allergic diseases encompasses novel developments in the area of personalized medicine, disease phenotyping and endotyping, and the development and application of reliable biomarkers. A detailed clinical history and physical examination followed by the detection of IgE immunoreactivity against specific allergens still represents the state of the art. However, nowadays, further emphasis focuses on the optimization of diagnostic and therapeutic standards and a large number of studies have been investigating the biomarkers of allergic diseases, including asthma, atopic dermatitis, allergic rhinitis, food allergy, urticaria and anaphylaxis. Various biomarkers have been developed by omics technologies, some of which lead to a better classification of distinct phenotypes or endotypes. The introduction of biologicals to clinical practice increases the need for biomarkers for patient selection, prediction of outcomes and monitoring, to allow for an adequate choice of the duration of these costly and long-lasting therapies. Escalating healthcare costs together with questions about the efficacy of the current management of allergic diseases require further development of a biomarker-driven approach. Here, we review biomarkers in diagnosis and treatment of asthma, atopic dermatitis, allergic rhinitis, viral infections, chronic rhinosinusitis, food allergy, drug hypersensitivity and allergen immunotherapy with a special emphasis on specific IgE, the microbiome and the epithelial barrier. In addition, EAACI guidelines on biologicals are discussed within the perspective of biomarkers. http://hdl.handle.net/20.500.12105/18129 |
| spellingShingle | Biomarkers for diagnosis and prediction of therapy responses in allergic diseases and asthma. Breiteneder, Heimo Allergen immunotherapy Allergic rhinitis Asthma phenotypes and endotypes Biomarkers Food allergy Asthma Dermatitis, Atopic Food Hypersensitivity Humans Hypersensitivity Rhinitis, Allergic |
| title | Biomarkers for diagnosis and prediction of therapy responses in allergic diseases and asthma. |
| title_full | Biomarkers for diagnosis and prediction of therapy responses in allergic diseases and asthma. |
| title_fullStr | Biomarkers for diagnosis and prediction of therapy responses in allergic diseases and asthma. |
| title_full_unstemmed | Biomarkers for diagnosis and prediction of therapy responses in allergic diseases and asthma. |
| title_short | Biomarkers for diagnosis and prediction of therapy responses in allergic diseases and asthma. |
| title_sort | Biomarkers for diagnosis and prediction of therapy responses in allergic diseases and asthma. |
| topic | Allergen immunotherapy Allergic rhinitis Asthma phenotypes and endotypes Biomarkers Food allergy Asthma Dermatitis, Atopic Food Hypersensitivity Humans Hypersensitivity Rhinitis, Allergic |
| topic_facet | Allergen immunotherapy Allergic rhinitis Asthma phenotypes and endotypes Biomarkers Food allergy Asthma Dermatitis, Atopic Food Hypersensitivity Humans Hypersensitivity Rhinitis, Allergic |
| url | http://hdl.handle.net/20.500.12105/18129 |