Efficacy and Safety of Dry Powder Antibiotics: A Narrative Review
The use of inhaled antibiotics was initially almost exclusively confined to patients with cystic fibrosis (CF). However, it has been extended in recent decades to patients with non-CF bronchiectasis or chronic obstructive pulmonary disease who present with chronic bronchial infection by potentially...
| Authors: | ; ; ; ; ; |
|---|---|
| Format: | Article |
| Publication date: | 2023 |
| Country: | España |
| Institution: | Servizo Galego de Saúde (SERGAS) |
| Repository: | RUNA. Repositorio da Consellería de Sanidade e Sergas |
| OAI Identifier: | oai:runa.sergas.gal:20.500.11940/21422 |
| Online Access: | https://portalcientifico.sergas.gal//documentos/64995bb771c692789f1e07bc http://hdl.handle.net/20.500.11940/21422 |
| Access Level: | Open access |
| Keyword: | AS Lugo CHULA |
| _version_ | 1878735469359923200 |
|---|---|
| author | de la Rosa-Carrillo, D. |
| author2 | Suárez-Cuartín, G. Sibila, O. Golpe Gómez, Rafael Girón, R.-M. Martínez-García, M.-Á. |
| author2_role | author author author author author |
| author_browse | Girón, R.-M. Golpe Gómez, Rafael Martínez-García, M.-Á. Sibila, O. Suárez-Cuartín, G. de la Rosa-Carrillo, D. |
| author_facet | de la Rosa-Carrillo, D. Suárez-Cuartín, G. Sibila, O. Golpe Gómez, Rafael Girón, R.-M. Martínez-García, M.-Á. |
| author_role | author |
| collection | RUNA. Repositorio da Consellería de Sanidade e Sergas |
| description | The use of inhaled antibiotics was initially almost exclusively confined to patients with cystic fibrosis (CF). However, it has been extended in recent decades to patients with non-CF bronchiectasis or chronic obstructive pulmonary disease who present with chronic bronchial infection by potentially pathogenic microorganisms. Inhaled antibiotics reach high concentrations in the area of infection, which enhances their effect and enables their long-term administration to defeat the most resistant infections, while minimizing possible adverse effects. New formulations of inhaled dry powder antibiotics have been developed, providing, among other advantages, faster preparation and administration of the drug, as well as avoiding the requirement to clean nebulization equipment. In this review, we analyze the advantages and disadvantages of the different types of devices that allow the inhalation of antibiotics, especially dry powder inhalers. We describe their general characteristics, the different inhalers on the market and the proper way to use them. We analyze the factors that influence the way in which the dry powder drug reaches the lower airways, as well as aspects of microbiological effectiveness and risks of resistance development. We review the scientific evidence on the use of colistin and tobramycin with this type of device, both in patients with CF and with non-CF bronchiectasis. Finally, we discuss the literature on the development of new dry powder antibiotics. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_7d54428a78c61dacbe2f1b648d64ea55 |
| institution | Servizo Galego de Saúde (SERGAS) |
| instname_str | Servizo Galego de Saúde (SERGAS) |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:runa.sergas.gal:20.500.11940/21422 |
| publishDate | 2023 |
| publishDateSort | 2023 |
| reponame_str | RUNA. Repositorio da Consellería de Sanidade e Sergas |
| spelling | Efficacy and Safety of Dry Powder Antibiotics: A Narrative Review de la Rosa-Carrillo, D. Suárez-Cuartín, G. Sibila, O. Golpe Gómez, Rafael Girón, R.-M. Martínez-García, M.-Á. AS Lugo CHULA The use of inhaled antibiotics was initially almost exclusively confined to patients with cystic fibrosis (CF). However, it has been extended in recent decades to patients with non-CF bronchiectasis or chronic obstructive pulmonary disease who present with chronic bronchial infection by potentially pathogenic microorganisms. Inhaled antibiotics reach high concentrations in the area of infection, which enhances their effect and enables their long-term administration to defeat the most resistant infections, while minimizing possible adverse effects. New formulations of inhaled dry powder antibiotics have been developed, providing, among other advantages, faster preparation and administration of the drug, as well as avoiding the requirement to clean nebulization equipment. In this review, we analyze the advantages and disadvantages of the different types of devices that allow the inhalation of antibiotics, especially dry powder inhalers. We describe their general characteristics, the different inhalers on the market and the proper way to use them. We analyze the factors that influence the way in which the dry powder drug reaches the lower airways, as well as aspects of microbiological effectiveness and risks of resistance development. We review the scientific evidence on the use of colistin and tobramycin with this type of device, both in patients with CF and with non-CF bronchiectasis. Finally, we discuss the literature on the development of new dry powder antibiotics. https://portalcientifico.sergas.gal//documentos/64995bb771c692789f1e07bc http://hdl.handle.net/20.500.11940/21422 |
| spellingShingle | Efficacy and Safety of Dry Powder Antibiotics: A Narrative Review de la Rosa-Carrillo, D. AS Lugo CHULA |
| title | Efficacy and Safety of Dry Powder Antibiotics: A Narrative Review |
| title_full | Efficacy and Safety of Dry Powder Antibiotics: A Narrative Review |
| title_fullStr | Efficacy and Safety of Dry Powder Antibiotics: A Narrative Review |
| title_full_unstemmed | Efficacy and Safety of Dry Powder Antibiotics: A Narrative Review |
| title_short | Efficacy and Safety of Dry Powder Antibiotics: A Narrative Review |
| title_sort | Efficacy and Safety of Dry Powder Antibiotics: A Narrative Review |
| topic | AS Lugo CHULA |
| topic_facet | AS Lugo CHULA |
| url | https://portalcientifico.sergas.gal//documentos/64995bb771c692789f1e07bc http://hdl.handle.net/20.500.11940/21422 |