Inborn errors of metabolism: Lessons from iPSC models
The possibility of reprogramming human somatic cells to pluripotency has opened unprecedented opportunities for creating genuinely human experimental models of disease. Inborn errors of metabolism (IEMs) constitute a greatly heterogeneous class of diseases that appear, in principle, especially suite...
| Authors: | ; ; |
|---|---|
| Format: | Article |
| Status: | Published version |
| Publication date: | 2021 |
| Country: | España |
| Institution: | Universidad de Barcelona |
| Repository: | Dipòsit Digital de la UB |
| OAI Identifier: | oai:diposit.ub.edu:2445/179742 |
| Online Access: | https://hdl.handle.net/2445/179742 |
| Access Level: | Open access |
| Keyword: | Cèl·lules mare Metabolisme Bioenginyeria Stem cells Metabolism Bioengineering |
| _version_ | 1878735469117702144 |
|---|---|
| author | Escribá, Rubén |
| author2 | Ferrer Lorente, Raquel Raya Chamorro, Ángel |
| author2_role | author author |
| author_browse | Escribá, Rubén Ferrer Lorente, Raquel Raya Chamorro, Ángel |
| author_facet | Escribá, Rubén Ferrer Lorente, Raquel Raya Chamorro, Ángel |
| author_role | author |
| collection | Dipòsit Digital de la UB |
| description | The possibility of reprogramming human somatic cells to pluripotency has opened unprecedented opportunities for creating genuinely human experimental models of disease. Inborn errors of metabolism (IEMs) constitute a greatly heterogeneous class of diseases that appear, in principle, especially suited to be modeled by iPSC-based technology. Indeed, dozens of IEMs have already been modeled to some extent using patient-specific iPSCs. Here, we review the advantages and disadvantages of iPSC-based disease modeling in the context of IEMs, as well as particular challenges associated to this approach, together with solutions researchers have proposed to tackle them. We have structured this review around six lessons that we have learnt from those previous modeling efforts, and that we believe should be carefully considered by researchers wishing to embark in future iPSC-based models of IEMs. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_7d4e8a3c5fb07d706ba462ae17efa51e |
| institution | Universidad de Barcelona |
| instname_str | Universidad de Barcelona |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:diposit.ub.edu:2445/179742 |
| publishDate | 2021 |
| publishDateSort | 2021 |
| publisher | Springer Science and Business Media LLC |
| publisherStr | Springer Science and Business Media LLC |
| reponame_str | Dipòsit Digital de la UB |
| spelling | Inborn errors of metabolism: Lessons from iPSC models Escribá, Rubén Ferrer Lorente, Raquel Raya Chamorro, Ángel Cèl·lules mare Metabolisme Bioenginyeria Stem cells Metabolism Bioengineering The possibility of reprogramming human somatic cells to pluripotency has opened unprecedented opportunities for creating genuinely human experimental models of disease. Inborn errors of metabolism (IEMs) constitute a greatly heterogeneous class of diseases that appear, in principle, especially suited to be modeled by iPSC-based technology. Indeed, dozens of IEMs have already been modeled to some extent using patient-specific iPSCs. Here, we review the advantages and disadvantages of iPSC-based disease modeling in the context of IEMs, as well as particular challenges associated to this approach, together with solutions researchers have proposed to tackle them. We have structured this review around six lessons that we have learnt from those previous modeling efforts, and that we believe should be carefully considered by researchers wishing to embark in future iPSC-based models of IEMs. Springer Science and Business Media LLC https://hdl.handle.net/2445/179742 |
| spellingShingle | Inborn errors of metabolism: Lessons from iPSC models Escribá, Rubén Cèl·lules mare Metabolisme Bioenginyeria Stem cells Metabolism Bioengineering |
| status_str | publishedVersion |
| title | Inborn errors of metabolism: Lessons from iPSC models |
| title_full | Inborn errors of metabolism: Lessons from iPSC models |
| title_fullStr | Inborn errors of metabolism: Lessons from iPSC models |
| title_full_unstemmed | Inborn errors of metabolism: Lessons from iPSC models |
| title_short | Inborn errors of metabolism: Lessons from iPSC models |
| title_sort | Inborn errors of metabolism: Lessons from iPSC models |
| topic | Cèl·lules mare Metabolisme Bioenginyeria Stem cells Metabolism Bioengineering |
| topic_facet | Cèl·lules mare Metabolisme Bioenginyeria Stem cells Metabolism Bioengineering |
| url | https://hdl.handle.net/2445/179742 |