Risk Score for Outcome After Allogeneic Hematopoietic Stem Cell Transplantation A Retrospective Analysis
BACKGROUND: It was investigated whether the European Group for Blood and Marrow Transplantation risk score, previously established for chronic myeloid leukemia, could be used to predict outcome after allogeneic hematopoietic stem cell transplantation (HSCT) for hematological disease in general. METH...
| Authors: | ; ; ; ; ; ; ; ; ; ; ; |
|---|---|
| Format: | Article |
| Status: | Published version |
| Publication date: | 2009 |
| Country: | España |
| Institution: | Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau) |
| Repository: | r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau |
| OAI Identifier: | oai:iibsantpau.fundanetsuite.com:p13114 |
| Online Access: | https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=13114 |
| Access Level: | Open access |
| Keyword: | hematopoietic stem cell transplantation outcome risk score allogeneic hematological malignancy leukemia |
| _version_ | 1878735430966312960 |
|---|---|
| author | Gratwohl, A |
| author2 | Stern, M Brand, R Apperley, J Baldomero, H de Witte, T Dini, G Rocha, V Passweg, J Sureda, A Tichelli, A Niederwieser, D |
| author2_role | author author author author author author author author author author author |
| author_browse | Apperley, J Baldomero, H Brand, R Dini, G Gratwohl, A Niederwieser, D Passweg, J Rocha, V Stern, M Sureda, A Tichelli, A de Witte, T |
| author_facet | Gratwohl, A Stern, M Brand, R Apperley, J Baldomero, H de Witte, T Dini, G Rocha, V Passweg, J Sureda, A Tichelli, A Niederwieser, D |
| author_role | author |
| collection | r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau |
| description | BACKGROUND: It was investigated whether the European Group for Blood and Marrow Transplantation risk score, previously established for chronic myeloid leukemia, could be used to predict outcome after allogeneic hematopoietic stem cell transplantation (HSCT) for hematological disease in general. METHODS: Age of patient, disease stage, time interval from diagnosis to transplant, donor type, and donor-recipient sex combination were used to establish a score from 0 to 7 points. Its validity was tested in 56,505 patients, 33,113 (58%) male, 23,392 female, median age 33 years (range, 0.5-77 years), with an allogeneic HSCT for a hematological disorder between 1980 and 2005. RESULTS: Survival probability at 5 years decreased from 71% (95% confidence interval [CI], 69%-73%) for risk score 0 for the whole cohort (75%, 95% Cl, 72%-78% for the most recent time cohort) to 24% (95% Cl, 21%-27% for risk score 6 and 7; 25%, 95% Cl, 22%-29% most recent cohort). Transplant-related mortality increased from 15% (95% Cl, 14%-17%) for risk score O (11%, 95% Cl, 9%-13%, most recent cohort) to 47% with risk score 6 and 7 (95% Cl, 44%-50%) for the whole cohort (45%, 95% Cl, 42%-48%, most recent cohort). The risk score was predictive in all disease categories, over all time periods, and was not altered by transplant techniques. CONCLUSIONS: Five well-defined pretransplant patient and donor characteristics give a reasonable risk estimate of allogeneic HSCT. This risk score can provide a basis for the decision between transplant and nontransplant strategies. Cancer 2009;115:4715-26. (C) 2009 American Cancer Society. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_7c92aeefa2b91cfe6b5cfda5e431f6b2 |
| institution | Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau) |
| instname_str | Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau) |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:iibsantpau.fundanetsuite.com:p13114 |
| publishDate | 2009 |
| publishDateSort | 2009 |
| publisher | WILEY |
| publisherStr | WILEY |
| reponame_str | r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau |
| spelling | Risk Score for Outcome After Allogeneic Hematopoietic Stem Cell Transplantation A Retrospective Analysis Gratwohl, A Stern, M Brand, R Apperley, J Baldomero, H de Witte, T Dini, G Rocha, V Passweg, J Sureda, A Tichelli, A Niederwieser, D hematopoietic stem cell transplantation outcome risk score allogeneic hematological malignancy leukemia BACKGROUND: It was investigated whether the European Group for Blood and Marrow Transplantation risk score, previously established for chronic myeloid leukemia, could be used to predict outcome after allogeneic hematopoietic stem cell transplantation (HSCT) for hematological disease in general. METHODS: Age of patient, disease stage, time interval from diagnosis to transplant, donor type, and donor-recipient sex combination were used to establish a score from 0 to 7 points. Its validity was tested in 56,505 patients, 33,113 (58%) male, 23,392 female, median age 33 years (range, 0.5-77 years), with an allogeneic HSCT for a hematological disorder between 1980 and 2005. RESULTS: Survival probability at 5 years decreased from 71% (95% confidence interval [CI], 69%-73%) for risk score 0 for the whole cohort (75%, 95% Cl, 72%-78% for the most recent time cohort) to 24% (95% Cl, 21%-27% for risk score 6 and 7; 25%, 95% Cl, 22%-29% most recent cohort). Transplant-related mortality increased from 15% (95% Cl, 14%-17%) for risk score O (11%, 95% Cl, 9%-13%, most recent cohort) to 47% with risk score 6 and 7 (95% Cl, 44%-50%) for the whole cohort (45%, 95% Cl, 42%-48%, most recent cohort). The risk score was predictive in all disease categories, over all time periods, and was not altered by transplant techniques. CONCLUSIONS: Five well-defined pretransplant patient and donor characteristics give a reasonable risk estimate of allogeneic HSCT. This risk score can provide a basis for the decision between transplant and nontransplant strategies. Cancer 2009;115:4715-26. (C) 2009 American Cancer Society. WILEY https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=13114 |
| spellingShingle | Risk Score for Outcome After Allogeneic Hematopoietic Stem Cell Transplantation A Retrospective Analysis Gratwohl, A hematopoietic stem cell transplantation outcome risk score allogeneic hematological malignancy leukemia |
| status_str | publishedVersion |
| title | Risk Score for Outcome After Allogeneic Hematopoietic Stem Cell Transplantation A Retrospective Analysis |
| title_full | Risk Score for Outcome After Allogeneic Hematopoietic Stem Cell Transplantation A Retrospective Analysis |
| title_fullStr | Risk Score for Outcome After Allogeneic Hematopoietic Stem Cell Transplantation A Retrospective Analysis |
| title_full_unstemmed | Risk Score for Outcome After Allogeneic Hematopoietic Stem Cell Transplantation A Retrospective Analysis |
| title_short | Risk Score for Outcome After Allogeneic Hematopoietic Stem Cell Transplantation A Retrospective Analysis |
| title_sort | Risk Score for Outcome After Allogeneic Hematopoietic Stem Cell Transplantation A Retrospective Analysis |
| topic | hematopoietic stem cell transplantation outcome risk score allogeneic hematological malignancy leukemia |
| topic_facet | hematopoietic stem cell transplantation outcome risk score allogeneic hematological malignancy leukemia |
| url | https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=13114 |