Microvascular and lymphatic dysfunction in HFpEF and its associated comorbidities
Heart failure with preserved ejection fraction (HFpEF) is a complex heterogeneous disease for which our pathophysiological understanding is still limited and specifc prevention and treatment strategies are lacking. HFpEF is characterised by diastolic dysfunction and cardiac remodelling (fbrosis, inf...
| Autores: | ; ; ; ; ; ; ; ; ; ; |
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| Tipo de documento: | Artículo |
| Fecha de publicación: | 2020 |
| País: | España |
| Institución: | Universidad de Navarra |
| Repositorio: | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| Lenguaje: | Inglés |
| OAI Identifier: | oai:dadun.unav.edu:10171/66473 |
| Acceso en línea: | https://hdl.handle.net/10171/66473 |
| Nivel de acceso: | Acceso abierto |
| Palabra clave: | Heart failure with preserved ejection fraction Coronary microvascular dysfunction Cardiac lymphatic dysfunction Infammation Myocardial fbrosis Cardiac metabolism |
| _version_ | 1878735369452650496 |
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| author | Cuijpers, I. (Ilona)|||/items/18b5a8f5-1c8f-4a8b-b2af-bbfe65f82938 |
| author2 | Simmonds, S. (Steven J.)|||/items/394bcf7a-7227-467e-b3ed-fe6b7112a375 Bilsen, M. (Marc) van|||/items/3bdfe950-4b5e-472c-b676-f0b2a664fe2d Czarnowska, E. (Elzbieta)|||/items/f47eb91a-4975-4fa7-88bd-f5167a62829a González-Miqueo, A. (Aránzazu)|||/items/74f4670c-e6aa-43b6-82f9-f6ed120089cb Heymans, S. (Stephane)|||/items/640c68d4-b80a-4923-bf08-10f868604375 Kuhn, A.R. (Annika R.)|||/items/941f8d5b-7ded-4344-8aac-4d49a5971549 Mulder, P. (Paul)|||/items/b77a19af-d842-4f56-99ed-10911ed169e9 Ratajska, A. (Anna)|||/items/f7a08a78-7058-436d-8561-f59d07638c55 Jones, E.A.V. (Elizabeth A. V.)|||/items/746017fa-3c62-4539-aab6-7411732a08a9 Brakenhielm, E. (Ebba)|||/items/5f91c870-72f7-4d31-bfc8-336cb9a3f191 |
| author2_role | author author author author author author author author author author |
| author_browse | Bilsen, M. (Marc) van|||/items/3bdfe950-4b5e-472c-b676-f0b2a664fe2d Brakenhielm, E. (Ebba)|||/items/5f91c870-72f7-4d31-bfc8-336cb9a3f191 Cuijpers, I. (Ilona)|||/items/18b5a8f5-1c8f-4a8b-b2af-bbfe65f82938 Czarnowska, E. (Elzbieta)|||/items/f47eb91a-4975-4fa7-88bd-f5167a62829a González-Miqueo, A. (Aránzazu)|||/items/74f4670c-e6aa-43b6-82f9-f6ed120089cb Heymans, S. (Stephane)|||/items/640c68d4-b80a-4923-bf08-10f868604375 Jones, E.A.V. (Elizabeth A. V.)|||/items/746017fa-3c62-4539-aab6-7411732a08a9 Kuhn, A.R. (Annika R.)|||/items/941f8d5b-7ded-4344-8aac-4d49a5971549 Mulder, P. (Paul)|||/items/b77a19af-d842-4f56-99ed-10911ed169e9 Ratajska, A. (Anna)|||/items/f7a08a78-7058-436d-8561-f59d07638c55 Simmonds, S. (Steven J.)|||/items/394bcf7a-7227-467e-b3ed-fe6b7112a375 |
| author_facet | Cuijpers, I. (Ilona)|||/items/18b5a8f5-1c8f-4a8b-b2af-bbfe65f82938 Simmonds, S. (Steven J.)|||/items/394bcf7a-7227-467e-b3ed-fe6b7112a375 Bilsen, M. (Marc) van|||/items/3bdfe950-4b5e-472c-b676-f0b2a664fe2d Czarnowska, E. (Elzbieta)|||/items/f47eb91a-4975-4fa7-88bd-f5167a62829a González-Miqueo, A. (Aránzazu)|||/items/74f4670c-e6aa-43b6-82f9-f6ed120089cb Heymans, S. (Stephane)|||/items/640c68d4-b80a-4923-bf08-10f868604375 Kuhn, A.R. (Annika R.)|||/items/941f8d5b-7ded-4344-8aac-4d49a5971549 Mulder, P. (Paul)|||/items/b77a19af-d842-4f56-99ed-10911ed169e9 Ratajska, A. (Anna)|||/items/f7a08a78-7058-436d-8561-f59d07638c55 Jones, E.A.V. (Elizabeth A. V.)|||/items/746017fa-3c62-4539-aab6-7411732a08a9 Brakenhielm, E. (Ebba)|||/items/5f91c870-72f7-4d31-bfc8-336cb9a3f191 |
| author_role | author |
| collection | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| description | Heart failure with preserved ejection fraction (HFpEF) is a complex heterogeneous disease for which our pathophysiological understanding is still limited and specifc prevention and treatment strategies are lacking. HFpEF is characterised by diastolic dysfunction and cardiac remodelling (fbrosis, infammation, and hypertrophy). Recently, microvascular dysfunction and chronic low-grade infammation have been proposed to participate in HFpEF development. Furthermore, several recent studies demonstrated the occurrence of generalized lymphatic dysfunction in experimental models of risk factors for HFpEF, including obesity, hypercholesterolaemia, type 2 diabetes mellitus (T2DM), hypertension, and aging. Here, we review the evidence for a combined role of coronary (micro)vascular dysfunction and lymphatic vessel alterations in mediating key pathological steps in HFpEF, including reduced cardiac perfusion, chronic low-grade infammation, and myocardial oedema, and their impact on cardiac metabolic alterations (oxygen and nutrient supply/demand imbalance), fbrosis, and cardiomyocyte stifness. We focus primarily on HFpEF caused by metabolic risk factors, such as obesity, T2DM, hypertension, and aging. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_7b5c18925e7c4c1fedbfe96c78cfd917 |
| institution | Universidad de Navarra |
| instname_str | Universidad de Navarra |
| language | eng |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:dadun.unav.edu:10171/66473 |
| publishDate | 2020 |
| publishDateSort | 2020 |
| publisher | Springer |
| publisherStr | Springer |
| reponame_str | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| spelling | Microvascular and lymphatic dysfunction in HFpEF and its associated comorbidities Cuijpers, I. (Ilona)|||/items/18b5a8f5-1c8f-4a8b-b2af-bbfe65f82938 Simmonds, S. (Steven J.)|||/items/394bcf7a-7227-467e-b3ed-fe6b7112a375 Bilsen, M. (Marc) van|||/items/3bdfe950-4b5e-472c-b676-f0b2a664fe2d Czarnowska, E. (Elzbieta)|||/items/f47eb91a-4975-4fa7-88bd-f5167a62829a González-Miqueo, A. (Aránzazu)|||/items/74f4670c-e6aa-43b6-82f9-f6ed120089cb Heymans, S. (Stephane)|||/items/640c68d4-b80a-4923-bf08-10f868604375 Kuhn, A.R. (Annika R.)|||/items/941f8d5b-7ded-4344-8aac-4d49a5971549 Mulder, P. (Paul)|||/items/b77a19af-d842-4f56-99ed-10911ed169e9 Ratajska, A. (Anna)|||/items/f7a08a78-7058-436d-8561-f59d07638c55 Jones, E.A.V. (Elizabeth A. V.)|||/items/746017fa-3c62-4539-aab6-7411732a08a9 Brakenhielm, E. (Ebba)|||/items/5f91c870-72f7-4d31-bfc8-336cb9a3f191 Heart failure with preserved ejection fraction Coronary microvascular dysfunction Cardiac lymphatic dysfunction Infammation Myocardial fbrosis Cardiac metabolism Heart failure with preserved ejection fraction (HFpEF) is a complex heterogeneous disease for which our pathophysiological understanding is still limited and specifc prevention and treatment strategies are lacking. HFpEF is characterised by diastolic dysfunction and cardiac remodelling (fbrosis, infammation, and hypertrophy). Recently, microvascular dysfunction and chronic low-grade infammation have been proposed to participate in HFpEF development. Furthermore, several recent studies demonstrated the occurrence of generalized lymphatic dysfunction in experimental models of risk factors for HFpEF, including obesity, hypercholesterolaemia, type 2 diabetes mellitus (T2DM), hypertension, and aging. Here, we review the evidence for a combined role of coronary (micro)vascular dysfunction and lymphatic vessel alterations in mediating key pathological steps in HFpEF, including reduced cardiac perfusion, chronic low-grade infammation, and myocardial oedema, and their impact on cardiac metabolic alterations (oxygen and nutrient supply/demand imbalance), fbrosis, and cardiomyocyte stifness. We focus primarily on HFpEF caused by metabolic risk factors, such as obesity, T2DM, hypertension, and aging. Springer https://hdl.handle.net/10171/66473 |
| spellingShingle | Microvascular and lymphatic dysfunction in HFpEF and its associated comorbidities Cuijpers, I. (Ilona)|||/items/18b5a8f5-1c8f-4a8b-b2af-bbfe65f82938 Heart failure with preserved ejection fraction Coronary microvascular dysfunction Cardiac lymphatic dysfunction Infammation Myocardial fbrosis Cardiac metabolism |
| title | Microvascular and lymphatic dysfunction in HFpEF and its associated comorbidities |
| title_full | Microvascular and lymphatic dysfunction in HFpEF and its associated comorbidities |
| title_fullStr | Microvascular and lymphatic dysfunction in HFpEF and its associated comorbidities |
| title_full_unstemmed | Microvascular and lymphatic dysfunction in HFpEF and its associated comorbidities |
| title_short | Microvascular and lymphatic dysfunction in HFpEF and its associated comorbidities |
| title_sort | Microvascular and lymphatic dysfunction in HFpEF and its associated comorbidities |
| topic | Heart failure with preserved ejection fraction Coronary microvascular dysfunction Cardiac lymphatic dysfunction Infammation Myocardial fbrosis Cardiac metabolism |
| topic_facet | Heart failure with preserved ejection fraction Coronary microvascular dysfunction Cardiac lymphatic dysfunction Infammation Myocardial fbrosis Cardiac metabolism |
| url | https://hdl.handle.net/10171/66473 |