Mosaic loss of chromosome Y is associated with common variation near TCL1A
Mosaic loss of chromosome Y (mLOY) leading to gonosomal XY/XO commonly occurs during aging, particularly in smokers. We investigated whether mLOY was associated with non-hematological cancer in three prospective cohorts (8,679 cancer cases and 5,110 cancer-free controls) and genetic susceptibility t...
| Autores: | ; ; ; ; |
|---|---|
| Tipo de documento: | Artículo |
| Estado: | Accepted version |
| Fecha de publicación: | 2016 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:10230/27094 |
| Acceso en línea: | http://hdl.handle.net/10230/27094 http://dx.doi.org/10.1038/ng.3545 |
| Nivel de acceso: | Acceso abierto |
| Palabra clave: | Cromosomes humans -- Anomalies |
| _version_ | 1878734981407178753 |
|---|---|
| author | Zhou, W. |
| author2 | Real, Francisco X. Rodríguez Santiago, Benjamín Pérez Jurado, Luis Alberto Chanock, Stephen J. |
| author2_role | author author author author |
| author_browse | Chanock, Stephen J. Pérez Jurado, Luis Alberto Real, Francisco X. Rodríguez Santiago, Benjamín Zhou, W. |
| author_facet | Zhou, W. Real, Francisco X. Rodríguez Santiago, Benjamín Pérez Jurado, Luis Alberto Chanock, Stephen J. |
| author_role | author |
| collection | Recercat. Dipósit de la Recerca de Catalunya |
| description | Mosaic loss of chromosome Y (mLOY) leading to gonosomal XY/XO commonly occurs during aging, particularly in smokers. We investigated whether mLOY was associated with non-hematological cancer in three prospective cohorts (8,679 cancer cases and 5,110 cancer-free controls) and genetic susceptibility to mLOY. Overall, mLOY was observed in 7% of men, and its prevalence increased with age (per-year odds ratio (OR) = 1.13, 95% confidence interval (CI) = 1.12-1.15; P < 2 × 10(-16)), reaching 18.7% among men over 80 years old. mLOY was associated with current smoking (OR = 2.35, 95% CI = 1.82-3.03; P = 5.55 × 10(-11)), but the association weakened with years after cessation. mLOY was not consistently associated with overall or specific cancer risk (for example, bladder, lung or prostate cancer) nor with cancer survival after diagnosis (multivariate-adjusted hazard ratio = 0.87, 95% CI = 0.73-1.04; P = 0.12). In a genome-wide association study, we observed the first example of a common susceptibility locus for genetic mosaicism, specifically mLOY, which maps to TCL1A at 14q32.13, marked by rs2887399 (OR = 1.55, 95% CI = 1.36-1.78; P = 1.37 × 10(-10)). |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_73a648f8dae71bdf6bc9d89cd3e4fee4 |
| institution | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| instname_str | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:recercat.cat:10230/27094 |
| publishDate | 2016 |
| publishDateSort | 2016 |
| publisher | Nature Publishing Group |
| publisherStr | Nature Publishing Group |
| reponame_str | Recercat. Dipósit de la Recerca de Catalunya |
| spelling | Mosaic loss of chromosome Y is associated with common variation near TCL1A Zhou, W. Real, Francisco X. Rodríguez Santiago, Benjamín Pérez Jurado, Luis Alberto Chanock, Stephen J. Cromosomes humans -- Anomalies Mosaic loss of chromosome Y (mLOY) leading to gonosomal XY/XO commonly occurs during aging, particularly in smokers. We investigated whether mLOY was associated with non-hematological cancer in three prospective cohorts (8,679 cancer cases and 5,110 cancer-free controls) and genetic susceptibility to mLOY. Overall, mLOY was observed in 7% of men, and its prevalence increased with age (per-year odds ratio (OR) = 1.13, 95% confidence interval (CI) = 1.12-1.15; P < 2 × 10(-16)), reaching 18.7% among men over 80 years old. mLOY was associated with current smoking (OR = 2.35, 95% CI = 1.82-3.03; P = 5.55 × 10(-11)), but the association weakened with years after cessation. mLOY was not consistently associated with overall or specific cancer risk (for example, bladder, lung or prostate cancer) nor with cancer survival after diagnosis (multivariate-adjusted hazard ratio = 0.87, 95% CI = 0.73-1.04; P = 0.12). In a genome-wide association study, we observed the first example of a common susceptibility locus for genetic mosaicism, specifically mLOY, which maps to TCL1A at 14q32.13, marked by rs2887399 (OR = 1.55, 95% CI = 1.36-1.78; P = 1.37 × 10(-10)). This project has been funded in whole or in part with federal funds from the National Cancer Institute, US National Institutes of Health, under contract HHSN261200800001E. The content of this publication does not necessarily reflect the views or policies of the US Department of Health and Human Services nor does mention of trade names, commercial products or organizations imply endorsement by the US government. Nature Publishing Group http://hdl.handle.net/10230/27094 http://dx.doi.org/10.1038/ng.3545 |
| spellingShingle | Mosaic loss of chromosome Y is associated with common variation near TCL1A Zhou, W. Cromosomes humans -- Anomalies |
| status_str | acceptedVersion |
| title | Mosaic loss of chromosome Y is associated with common variation near TCL1A |
| title_full | Mosaic loss of chromosome Y is associated with common variation near TCL1A |
| title_fullStr | Mosaic loss of chromosome Y is associated with common variation near TCL1A |
| title_full_unstemmed | Mosaic loss of chromosome Y is associated with common variation near TCL1A |
| title_short | Mosaic loss of chromosome Y is associated with common variation near TCL1A |
| title_sort | Mosaic loss of chromosome Y is associated with common variation near TCL1A |
| topic | Cromosomes humans -- Anomalies |
| topic_facet | Cromosomes humans -- Anomalies |
| url | http://hdl.handle.net/10230/27094 http://dx.doi.org/10.1038/ng.3545 |