Cause of Death in Heart Failure Based on Etiology
We assessed differences in long-term all-cause and cardiovascular (CV) mortality in heart failure (HF) outpatients based on the etiology of HF. Consecutive patients admitted to the HF Clinic from August 2001 to September 2019 (N = 2587) were considered for inclusion. HF etiology was divided into isc...
| Autores: | ; ; ; ; ; ; ; ; ; ; ; ; ; ; |
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| Tipo de documento: | Artículo |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Lenguaje: | Inglés |
| OAI Identifier: | oai:ddd.uab.cat:256046 |
| Acceso en línea: | https://ddd.uab.cat/record/256046 https://dx.doi.org/urn:doi:10.3390/jcm11030784 |
| Nivel de acceso: | Acceso abierto |
| Palabra clave: | Heart failure with reduced ejection fraction Heart failure with preserved ejection fraction Heart failure etiology |
| _version_ | 1878734971608236032 |
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| author | Spitaleri, Giosafat|||0000-0002-0214-9082 |
| author2 | Zamora, Elisabet|||0000-0001-5317-7481 Cediel, Germán|||0000-0001-9667-7507 Codina, Pau|||0000-0002-2469-5711 Santiago Vacas, Evelyn|||0000-0001-7511-406X Domingo, Mar|||0000-0002-2935-1272 Lupón, Josep|||0000-0002-5601-9611 Santesmases, Javier|||0000-0002-1226-1617 Diez-Quevedo, Crisanto|||0000-0002-0705-295X Troya, Maria Isabel Boldo Alcaine, Maria Altimir Losada, Salvador Alonso Pedrol, Núria|||0000-0001-9687-8050 González Fernández, Beatriz|||0000-0002-3699-9392 Bayés-Genís, Antoni|||0000-0002-3044-197X |
| author2_role | author author author author author author author author author author author author author author |
| author_browse | Alonso Pedrol, Núria|||0000-0001-9687-8050 Altimir Losada, Salvador Bayés-Genís, Antoni|||0000-0002-3044-197X Boldo Alcaine, Maria Cediel, Germán|||0000-0001-9667-7507 Codina, Pau|||0000-0002-2469-5711 Diez-Quevedo, Crisanto|||0000-0002-0705-295X Domingo, Mar|||0000-0002-2935-1272 González Fernández, Beatriz|||0000-0002-3699-9392 Lupón, Josep|||0000-0002-5601-9611 Santesmases, Javier|||0000-0002-1226-1617 Santiago Vacas, Evelyn|||0000-0001-7511-406X Spitaleri, Giosafat|||0000-0002-0214-9082 Troya, Maria Isabel Zamora, Elisabet|||0000-0001-5317-7481 |
| author_facet | Spitaleri, Giosafat|||0000-0002-0214-9082 Zamora, Elisabet|||0000-0001-5317-7481 Cediel, Germán|||0000-0001-9667-7507 Codina, Pau|||0000-0002-2469-5711 Santiago Vacas, Evelyn|||0000-0001-7511-406X Domingo, Mar|||0000-0002-2935-1272 Lupón, Josep|||0000-0002-5601-9611 Santesmases, Javier|||0000-0002-1226-1617 Diez-Quevedo, Crisanto|||0000-0002-0705-295X Troya, Maria Isabel Boldo Alcaine, Maria Altimir Losada, Salvador Alonso Pedrol, Núria|||0000-0001-9687-8050 González Fernández, Beatriz|||0000-0002-3699-9392 Bayés-Genís, Antoni|||0000-0002-3044-197X |
| author_role | author |
| collection | Dipòsit Digital de Documents de la UAB |
| description | We assessed differences in long-term all-cause and cardiovascular (CV) mortality in heart failure (HF) outpatients based on the etiology of HF. Consecutive patients admitted to the HF Clinic from August 2001 to September 2019 (N = 2587) were considered for inclusion. HF etiology was divided into ischemic heart disease (IHD), dilated cardiomyopathy (DCM), hypertensive heart disease, alcoholic cardiomyopathy, drug-induced cardiomyopathy (DICM), valvular heart disease, and hypertrophic cardiomyopathy. All-cause death and CV death were the primary end points. Among 2387 patients included in the analysis (mean age 66.5 ± 12.5 years, 71.3% men), 1317 deaths were recorded (731 from CV cause) over a maximum follow-up of 18 years (median 4.1 years, interquartile range (IQR) 2-7.8). Considering IHD as the reference, only DCM had a lower risk of all-cause death (adjusted hazard ratio (aHR) 0.68, 95% confidence interval (CI) 0.56-0.83, p < 0.001), and only DICM had a higher risk of all-cause death (aHR 1.47, 95% CI 1.02-2.11, p = 0.04). However, almost all etiologies had a significantly lower risk of CV death than IHD. Among the studied HF etiologies, DCM and DICM have the lowest and highest risk of all-cause death, respectively, whereas IHD has the highest adjusted risk of CV death. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_736f57f902bb7fa43a10200a32396db4 |
| institution | Universitat Autònoma de Barcelona |
| instname_str | Universitat Autònoma de Barcelona |
| language | eng |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:ddd.uab.cat:256046 |
| publishDate | 2022 |
| publishDateSort | 2022 |
| reponame_str | Dipòsit Digital de Documents de la UAB |
| spelling | Cause of Death in Heart Failure Based on Etiology Long-Term Cohort Study of All-Cause and Cardiovascular Mortality Spitaleri, Giosafat|||0000-0002-0214-9082 Zamora, Elisabet|||0000-0001-5317-7481 Cediel, Germán|||0000-0001-9667-7507 Codina, Pau|||0000-0002-2469-5711 Santiago Vacas, Evelyn|||0000-0001-7511-406X Domingo, Mar|||0000-0002-2935-1272 Lupón, Josep|||0000-0002-5601-9611 Santesmases, Javier|||0000-0002-1226-1617 Diez-Quevedo, Crisanto|||0000-0002-0705-295X Troya, Maria Isabel Boldo Alcaine, Maria Altimir Losada, Salvador Alonso Pedrol, Núria|||0000-0001-9687-8050 González Fernández, Beatriz|||0000-0002-3699-9392 Bayés-Genís, Antoni|||0000-0002-3044-197X Heart failure with reduced ejection fraction Heart failure with preserved ejection fraction Heart failure etiology We assessed differences in long-term all-cause and cardiovascular (CV) mortality in heart failure (HF) outpatients based on the etiology of HF. Consecutive patients admitted to the HF Clinic from August 2001 to September 2019 (N = 2587) were considered for inclusion. HF etiology was divided into ischemic heart disease (IHD), dilated cardiomyopathy (DCM), hypertensive heart disease, alcoholic cardiomyopathy, drug-induced cardiomyopathy (DICM), valvular heart disease, and hypertrophic cardiomyopathy. All-cause death and CV death were the primary end points. Among 2387 patients included in the analysis (mean age 66.5 ± 12.5 years, 71.3% men), 1317 deaths were recorded (731 from CV cause) over a maximum follow-up of 18 years (median 4.1 years, interquartile range (IQR) 2-7.8). Considering IHD as the reference, only DCM had a lower risk of all-cause death (adjusted hazard ratio (aHR) 0.68, 95% confidence interval (CI) 0.56-0.83, p < 0.001), and only DICM had a higher risk of all-cause death (aHR 1.47, 95% CI 1.02-2.11, p = 0.04). However, almost all etiologies had a significantly lower risk of CV death than IHD. Among the studied HF etiologies, DCM and DICM have the lowest and highest risk of all-cause death, respectively, whereas IHD has the highest adjusted risk of CV death. https://ddd.uab.cat/record/256046 https://dx.doi.org/urn:doi:10.3390/jcm11030784 |
| spellingShingle | Cause of Death in Heart Failure Based on Etiology Spitaleri, Giosafat|||0000-0002-0214-9082 Heart failure with reduced ejection fraction Heart failure with preserved ejection fraction Heart failure etiology |
| title | Cause of Death in Heart Failure Based on Etiology |
| title_full | Cause of Death in Heart Failure Based on Etiology |
| title_fullStr | Cause of Death in Heart Failure Based on Etiology |
| title_full_unstemmed | Cause of Death in Heart Failure Based on Etiology |
| title_short | Cause of Death in Heart Failure Based on Etiology |
| title_sort | Cause of Death in Heart Failure Based on Etiology |
| topic | Heart failure with reduced ejection fraction Heart failure with preserved ejection fraction Heart failure etiology |
| topic_facet | Heart failure with reduced ejection fraction Heart failure with preserved ejection fraction Heart failure etiology |
| url | https://ddd.uab.cat/record/256046 https://dx.doi.org/urn:doi:10.3390/jcm11030784 |